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company name :
Tocris Bioscience
product type :
chemical
product name :
1283/10
catalog :
1283/10
quantity :
10 mg
price :
315 USD
more info or order :
citations: 30
Reference
Villa Bellosta R. ATP-based therapy prevents vascular calcification and extends longevity in a mouse model of Hutchinson-Gilford progeria syndrome. Proc Natl Acad Sci U S A. 2019;116:23698-23704 pubmed publisher
Perrot I, Michaud H, Giraudon Paoli M, Augier S, Docquier A, Gros L, et al. Blocking Antibodies Targeting the CD39/CD73 Immunosuppressive Pathway Unleash Immune Responses in Combination Cancer Therapies. Cell Rep. 2019;27:2411-2425.e9 pubmed publisher
Kleiner J, Hollborn M, Wiedemann P, Bringmann A. Activator protein-1 contributes to the NaCl-induced expression of VEGF and PlGF in RPE cells. Mol Vis. 2018;24:647-666 pubmed
Ng P, McIntosh K, Hargrave G, Ho K, Paul A, Plevin R. Inhibition of cytokine-mediated JNK signalling by purinergic P2Y11 receptors, a novel protective mechanism in endothelial cells. Cell Signal. 2018;51:59-71 pubmed publisher
Gourdin N, Bossennec M, Rodriguez C, Vigano S, Machon C, Jandus C, et al. Autocrine Adenosine Regulates Tumor Polyfunctional CD73+CD4+ Effector T Cells Devoid of Immune Checkpoints. Cancer Res. 2018;78:3604-3618 pubmed publisher
Conley J, Radhakrishnan S, Valentino S, Tantama M. Imaging extracellular ATP with a genetically-encoded, ratiometric fluorescent sensor. PLoS ONE. 2017;12:e0187481 pubmed publisher
Chiu D, Tse A, Xu I, Di Cui J, Lai R, Li L, et al. Hypoxia inducible factor HIF-1 promotes myeloid-derived suppressor cells accumulation through ENTPD2/CD39L1 in hepatocellular carcinoma. Nat Commun. 2017;8:517 pubmed publisher
Wang S, Chennupati R, Kaur H, Iring A, Wettschureck N, Offermanns S. Endothelial cation channel PIEZO1 controls blood pressure by mediating flow-induced ATP release. J Clin Invest. 2016;126:4527-4536 pubmed publisher
Fang F, Yu M, Cavanagh M, Hutter Saunders J, Qi Q, Ye Z, et al. Expression of CD39 on Activated T Cells Impairs their Survival in Older Individuals. Cell Rep. 2016;14:1218-1231 pubmed publisher
Ye C, Geng Z, Dominguez D, Chen S, Fan J, Qin L, et al. Targeting Ornithine Decarboxylase by α-Difluoromethylornithine Inhibits Tumor Growth by Impairing Myeloid-Derived Suppressor Cells. J Immunol. 2016;196:915-23 pubmed publisher
Acton D, Miles G. Stimulation of Glia Reveals Modulation of Mammalian Spinal Motor Networks by Adenosine. PLoS ONE. 2015;10:e0134488 pubmed publisher
Billaud M, Chiu Y, Lohman A, Parpaite T, Butcher J, Mutchler S, et al. A molecular signature in the pannexin1 intracellular loop confers channel activation by the α1 adrenoreceptor in smooth muscle cells. Sci Signal. 2015;8:ra17 pubmed publisher
Campwala H, Sexton D, Crossman D, Fountain S. P2Y₆ receptor inhibition perturbs CCL2-evoked signalling in human monocytic and peripheral blood mononuclear cells. J Cell Sci. 2014;127:4964-73 pubmed publisher
Boyd Tressler A, Penuela S, Laird D, Dubyak G. Chemotherapeutic drugs induce ATP release via caspase-gated pannexin-1 channels and a caspase/pannexin-1-independent mechanism. J Biol Chem. 2014;289:27246-63 pubmed publisher
Carlsen E, Perrier J. Purines released from astrocytes inhibit excitatory synaptic transmission in the ventral horn of the spinal cord. Front Neural Circuits. 2014;8:60 pubmed publisher
Zhou J, Riquelme M, Gao X, Ellies L, Sun L, Jiang J. Differential impact of adenosine nucleotides released by osteocytes on breast cancer growth and bone metastasis. Oncogene. 2015;34:1831-42 pubmed publisher
Carneiro I, Timóteo M, Silva I, Vieira C, Baldaia C, Ferreirinha F, et al. Activation of P2Y6 receptors increases the voiding frequency in anaesthetized rats by releasing ATP from the bladder urothelium. Br J Pharmacol. 2014;171:3404-19 pubmed publisher
Hennel R, Brix N, Seidl K, Ernst A, Scheithauer H, Belka C, et al. Release of monocyte migration signals by breast cancer cell lines after ablative and fractionated ?-irradiation. Radiat Oncol. 2014;9:85 pubmed publisher
Ziemli ska E, K gler S, Schachner M, Wewi r I, Czarkowska Bauch J, Skup M. Overexpression of BDNF increases excitability of the lumbar spinal network and leads to robust early locomotor recovery in completely spinalized rats. PLoS ONE. 2014;9:e88833 pubmed publisher
Jansen R, Küçükosmanoglu A, de Haas M, Sapthu S, Otero J, Hegman I, et al. ABCC6 prevents ectopic mineralization seen in pseudoxanthoma elasticum by inducing cellular nucleotide release. Proc Natl Acad Sci U S A. 2013;110:20206-11 pubmed publisher
Sorrell M, Hauser K. Ligand-gated purinergic receptors regulate HIV-1 Tat and morphine related neurotoxicity in primary mouse striatal neuron-glia co-cultures. J Neuroimmune Pharmacol. 2014;9:233-44 pubmed publisher
Melhorn M, Brodsky A, Estanislau J, Khoory J, Illigens B, Hamachi I, et al. CR1-mediated ATP release by human red blood cells promotes CR1 clustering and modulates the immune transfer process. J Biol Chem. 2013;288:31139-53 pubmed publisher
Shabir S, Cross W, Kirkwood L, Pearson J, Appleby P, Walker D, et al. Functional expression of purinergic P2 receptors and transient receptor potential channels by the human urothelium. Am J Physiol Renal Physiol. 2013;305:F396-406 pubmed publisher
Ashpole N, Chawla A, Martin M, Brustovetsky T, Brustovetsky N, Hudmon A. Loss of calcium/calmodulin-dependent protein kinase II activity in cortical astrocytes decreases glutamate uptake and induces neurotoxic release of ATP. J Biol Chem. 2013;288:14599-611 pubmed publisher
Visovatti S, Hyman M, Bouïs D, Neubig R, McLaughlin V, Pinsky D. Increased CD39 nucleotidase activity on microparticles from patients with idiopathic pulmonary arterial hypertension. PLoS ONE. 2012;7:e40829 pubmed publisher
Yegutkin G, Wieringa B, Robson S, Jalkanen S. Metabolism of circulating ADP in the bloodstream is mediated via integrated actions of soluble adenylate kinase-1 and NTPDase1/CD39 activities. FASEB J. 2012;26:3875-83 pubmed publisher
Witts E, Panetta K, Miles G. Glial-derived adenosine modulates spinal motor networks in mice. J Neurophysiol. 2012;107:1925-34 pubmed publisher
Griffiths K, Pathan A, Minassian A, Sander C, Beveridge N, Hill A, et al. Th1/Th17 cell induction and corresponding reduction in ATP consumption following vaccination with the novel Mycobacterium tuberculosis vaccine MVA85A. PLoS ONE. 2011;6:e23463 pubmed publisher
Lorincz M, Geall F, Bao Y, Crunelli V, Hughes S. ATP-dependent infra-slow (<0.1 Hz) oscillations in thalamic networks. PLoS ONE. 2009;4:e4447 pubmed publisher
Kennedy C, Tasker P, Gallacher G, Westfall T. Identification of atropine- and P2X1 receptor antagonist-resistant, neurogenic contractions of the urinary bladder. J Neurosci. 2007;27:845-51 pubmed
product information
master code :
1283
SKU :
1283/10
product name :
ARL 67156 trisodium salt
unit size :
10 mg
description :
NTPDase inhibitor
target :
NTPDase Inhibitors
category :
Small Molecules
purity :
98%
observed molecular weight :
785.06
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
ARL 67156 trisodium salt is a selective NTPDase inhibitor (pIC50 = 4.62 and 5.1 in human blood and rat vas deferens respectively). ARL 67156 prevents vascular calcification and extends longevity in Hutchinson-Gilford progeria syndrome mice. ARL 67156 increases neurogenic contract response to nerve stimulation. ARL 67156 enhances parasympathetic neurotransmission in guinea-pig urinary bladder.
top caption :
NTPDase inhibitor
extended description :
NTPDase inhibitor
chemical name text :
6-N,N-Diethyl-D- , -dibromomethyleneATP trisodium salt
formula :
C15H21Br2N5O12P3.3Na
formula text :
C15H21Br2N5O12P3.3Na
cas num :
1021868-83-6
USD :
315 USD
product details :
NTPDase inhibitor
alt names :
FPL 67156
storage :
Store at -20░C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK