1280/10U | Tocris Bioscience 1280/10U product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

1280/10U

catalog :

1280/10U

quantity :

10 ug

price :

300 USD

more info or order :

Tocris Bioscience product webpage

citations: 18

Reference
Joe Y, Chen Y, Park J, Kim H, Rah S, Ryu J, et al. Cross-talk between CD38 and TTP Is Essential for Resolution of Inflammation during Microbial Sepsis. Cell Rep. 2020;30:1063-1076.e5 pubmed publisher
Chen D, Yang W, Han S, Yang H, Cen X, Liu J, et al. A Type IIb, but Not Type IIa, GnRH Receptor Mediates GnRH-Induced Release of Growth Hormone in the Ricefield Eel. Front Endocrinol (Lausanne). 2018;9:721 pubmed publisher
Hellmer C, Clemons M, Nawy S, Ichinose T. A group I metabotropic glutamate receptor controls synaptic gain between rods and rod bipolar cells in the mouse retina. Physiol Rep. 2018;6:e13885 pubmed publisher
Lim D, Mapelli L, Canonico P, Moccia F, Genazzani A. Neuronal Activity-Dependent Activation of Astroglial Calcineurin in Mouse Primary Hippocampal Cultures. Int J Mol Sci. 2018;19: pubmed publisher
Wakle Prabagaran M, Lorca R, Ma X, Stamnes S, Amazu C, Hsiao J, et al. BKCa channel regulates calcium oscillations induced by alpha-2-macroglobulin in human myometrial smooth muscle cells. Proc Natl Acad Sci U S A. 2016;113:E2335-44 pubmed publisher
Abedini A, Zamberlam G, Lapointe E, Tourigny C, Boyer A, Paquet M, et al. WNT5a is required for normal ovarian follicle development and antagonizes gonadotropin responsiveness in granulosa cells by suppressing canonical WNT signaling. FASEB J. 2016;30:1534-47 pubmed publisher
Azab W, Gramatica A, Herrmann A, Osterrieder N. Binding of alphaherpesvirus glycoprotein H to surface Î±4Î²1-integrins activates calcium-signaling pathways and induces phosphatidylserine exposure on the plasma membrane. MBio. 2015;6:e01552-15 pubmed publisher
Tabatadze N, Huang G, May R, Jain A, Woolley C. Sex Differences in Molecular Signaling at Inhibitory Synapses in the Hippocampus. J Neurosci. 2015;35:11252-65 pubmed publisher
Oh W, Parajuli L, Zito K. Heterosynaptic structural plasticity on local dendritic segments of hippocampal CA1 neurons. Cell Rep. 2015;10:162-9 pubmed publisher
Glanowska K, Moenter S. Differential regulation of GnRH secretion in the preoptic area (POA) and the median eminence (ME) in male mice. Endocrinology. 2015;156:231-41 pubmed publisher
Grafe L, Takacs A, Yee D, Flanagan Cato L. The role of the hypothalamic paraventricular nucleus and the organum vasculosum lateral terminalis in the control of sodium appetite in male rats. J Neurosci. 2014;34:9249-60 pubmed publisher
Nordman J, Kabbani N. Microtubule dynamics at the growth cone are mediated by ?7 nicotinic receptor activation of a G?q and IP3 receptor pathway. FASEB J. 2014;28:2995-3006 pubmed publisher
Bellono N, Najera J, Oancea E. UV light activates a G?q/11-coupled phototransduction pathway in human melanocytes. J Gen Physiol. 2014;143:203-14 pubmed publisher
Gao X, Liang Q, Chen Y, Wang H. Molecular mechanisms underlying the rapid arrhythmogenic action of bisphenol A in female rat hearts. Endocrinology. 2013;154:4607-17 pubmed publisher
Oh W, Hill T, Zito K. Synapse-specific and size-dependent mechanisms of spine structural plasticity accompanying synaptic weakening. Proc Natl Acad Sci U S A. 2013;110:E305-12 pubmed publisher
De Bock M, Wang N, Bol M, Decrock E, Ponsaerts R, Bultynck G, et al. Connexin 43 hemichannels contribute to cytoplasmic Ca2+ oscillations by providing a bimodal Ca2+-dependent Ca2+ entry pathway. J Biol Chem. 2012;287:12250-66 pubmed publisher
Xu H, Bae M, Tovar Y Romo L, Patel N, Bandaru V, Pomerantz D, et al. The human immunodeficiency virus coat protein gp120 promotes forward trafficking and surface clustering of NMDA receptors in membrane microdomains. J Neurosci. 2011;31:17074-90 pubmed publisher
Belal C, Ameli N, El Kommos A, Bezalel S, Al Khafaji A, Mughal M, et al. The homocysteine-inducible endoplasmic reticulum (ER) stress protein Herp counteracts mutant ?-synuclein-induced ER stress via the homeostatic regulation of ER-resident calcium release channel proteins. Hum Mol Genet. 2012;21:963-77 pubmed publisher

product information

master code :

1280

SKU :

1280/10U

product name :

(-)-Xestospongin C

unit size :

10 ug

description :

Reported inhibitor of IP3-dependent Ca2+ release

target :

Calcium Signaling Agents

category :

Small Molecules

observed molecular weight :

446.71

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

(-)-Xestospongin C is a reported inhibitor of IP3-dependent Ca2+ release. Inhibits bradykinin -induced Ca2+ release in PC12 cells and attenuates PHP-induced IL-2 production in Jurkat T cells. Exhibits no effect on ryanodine receptor-mediated Ca2+ release in PC12 cells and shows no apparent interaction with the IP3 binding site. Other subsequent reports show (-)-Xestospongin C to be ineffective as an antagonist of IP3-evoked Ca2+ release in IP3 recepto- expressing DT40 cells. Cell permeable. . NOTE: (-)-Xestospongin C is typically used at a final concentration ranging from 0.5 to 10 M. It is recommended to prepare stock solutions (10x to 100x) in DMSO or ethanol.

top caption :

Reported inhibitor of IP3-dependent Ca2+ release

extended description :

Reported inhibitor of IP3-dependent Ca2+ release

chemical name text :

(1R,4aR,11R,12aS,13S,16aS,23R,24aS)-Eicosahydro-5H,17H-1,23:11,13-diethano-2H,14H-[1,11]dioxacycloeicosino[2,3-b:12,13-b ]dipyridine

formula :

C28H50N2O2

formula text :

C28H50N2O2

cas num :

88903-69-9

USD :

300 USD

product details :

Reported inhibitor of IP3-dependent Ca2+ release

alt names :

XeC

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage