KN 93 | Tocris Bioscience 1278 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

KN 93

catalog :

1278

quantity :

1 mg

price :

216 USD

more info or order :

Tocris Bioscience product webpage

citations: 23

Reference
Weng Y, An R, Cassin J, Joseph J, Mi R, Wang C, et al. An Intrinsic Epigenetic Barrier for Functional Axon Regeneration. Neuron. 2017;94:337-346.e6 pubmed publisher
Abedini A, Zamberlam G, Lapointe E, Tourigny C, Boyer A, Paquet M, et al. WNT5a is required for normal ovarian follicle development and antagonizes gonadotropin responsiveness in granulosa cells by suppressing canonical WNT signaling. FASEB J. 2016;30:1534-47 pubmed publisher
Draganov D, Gopalakrishna Pillai S, Chen Y, Zuckerman N, Moeller S, Wang C, et al. Modulation of P2X4/P2X7/Pannexin-1 sensitivity to extracellular ATP via Ivermectin induces a non-apoptotic and inflammatory form of cancer cell death. Sci Rep. 2015;5:16222 pubmed publisher
Glovaci I, Chapman C. Activation of Phosphatidylinositol-Linked Dopamine Receptors Induces a Facilitation of Glutamate-Mediated Synaptic Transmission in the Lateral Entorhinal Cortex. PLoS ONE. 2015;10:e0131948 pubmed publisher
Cohen S, Li B, Tsien R, Ma H. Evolutionary and functional perspectives on signaling from neuronal surface to nucleus. Biochem Biophys Res Commun. 2015;460:88-99 pubmed publisher
Raka F, Di Sebastiano A, Kulhawy S, Ribeiro F, Godin C, Caetano F, et al. Ca(2+)/calmodulin-dependent protein kinase II interacts with group I metabotropic glutamate and facilitates receptor endocytosis and ERK1/2 signaling: role of Î²-amyloid. Mol Brain. 2015;8:21 pubmed publisher
GalvÃ¡n E, PÃ©rez Rosello T, GÃ³mez Lira G, Lara E, GutiÃ©rrez R, Barrionuevo G. Synapse-specific compartmentalization of signaling cascades for LTP induction in CA3 interneurons. Neuroscience. 2015;290:332-45 pubmed publisher
Bonnefond M, Lambert B, Giffard F, Abeilard E, Brotin E, Louis M, et al. Calcium signals inhibition sensitizes ovarian carcinoma cells to anti-Bcl-xL strategies through Mcl-1 down-regulation. Apoptosis. 2015;20:535-50 pubmed publisher
Nygaard V, Prasmickaite L, Vasiliauskaite K, Clancy T, Hovig E. Melanoma brain colonization involves the emergence of a brain-adaptive phenotype. Oncoscience. 2014;1:82-94 pubmed
Guemez Gamboa A, Xu L, Meng D, Spitzer N. Non-cell-autonomous mechanism of activity-dependent neurotransmitter switching. Neuron. 2014;82:1004-16 pubmed publisher
Hill B, Muldrew E. Oestrogen upregulates the sarcoplasmic reticulum Ca(2+) ATPase pump in coronary arteries. Clin Exp Pharmacol Physiol. 2014;41:430-6 pubmed publisher
Wang C, Held R, Hall B. SynGAP regulates protein synthesis and homeostatic synaptic plasticity in developing cortical networks. PLoS ONE. 2013;8:e83941 pubmed publisher
Bemben M, Shipman S, Hirai T, Herring B, Li Y, Badger J, et al. CaMKII phosphorylation of neuroligin-1 regulates excitatory synapses. Nat Neurosci. 2014;17:56-64 pubmed publisher
Arguello A, Hodges M, Wells A, Lara H, Xie X, Fuchs R. Involvement of amygdalar protein kinase A, but not calcium/calmodulin-dependent protein kinase II, in the reconsolidation of cocaine-related contextual memories in rats. Psychopharmacology (Berl). 2014;231:55-65 pubmed publisher
Seto S, Au A, Poon C, Zhang Q, Li R, Yeung J, et al. Acute simvastatin inhibits K ATP channels of porcine coronary artery myocytes. PLoS ONE. 2013;8:e66404 pubmed publisher
Balasubramanian R, Maruoka H, Jayasekara P, Gao Z, Jacobson K. AMP-activated protein kinase as regulator of P2Y(6) receptor-induced insulin secretion in mouse pancreatic β-cells. Biochem Pharmacol. 2013;85:991-8 pubmed publisher
Thayer D, Jan Y, Jan L. Increased neuronal activity fragments the Golgi complex. Proc Natl Acad Sci U S A. 2013;110:1482-7 pubmed publisher
El Gaamouch F, Buisson A, Moustié O, Lemieux M, Labrecque S, Bontempi B, et al. Interaction between ?CaMKII and GluN2B controls ERK-dependent plasticity. J Neurosci. 2012;32:10767-79 pubmed publisher
Mockett B, Guevremont D, Wutte M, Hulme S, Williams J, Abraham W. Calcium/calmodulin-dependent protein kinase II mediates group I metabotropic glutamate receptor-dependent protein synthesis and long-term depression in rat hippocampus. J Neurosci. 2011;31:7380-91 pubmed publisher
Xu T, Sotnikova T, Liang C, Zhang J, Jung J, Spealman R, et al. Hyperdopaminergic tone erodes prefrontal long-term potential via a D2 receptor-operated protein phosphatase gate. J Neurosci. 2009;29:14086-99 pubmed publisher
Pedersen T, Gurung I, Grace A, Huang C. Calmodulin kinase II initiates arrhythmogenicity during metabolic acidification in murine hearts. Acta Physiol (Oxf). 2009;197:13-25 pubmed publisher
Kim J, Tsien R. Synapse-specific adaptations to inactivity in hippocampal circuits achieve homeostatic gain control while dampening network reverberation. Neuron. 2008;58:925-37 pubmed publisher
Marsden K, Beattie J, Friedenthal J, Carroll R. NMDA receptor activation potentiates inhibitory transmission through GABA receptor-associated protein-dependent exocytosis of GABA(A) receptors. J Neurosci. 2007;27:14326-37 pubmed

product information

brand :

Tocris

master code :

1278

SKU :

1278/1

product name :

KN 93

description :

CaM kinase II inhibitor; also K+ channel blocker (KV)

target :

Calcium Binding Protein Modulator Inhibitors

category :

Small Molecules

unit size :

1 mg

purity :

98%

observed molecular weight :

501.04

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent, cell permeable inhibitor of CaM kinase II (IC50 = 0.37 M). Also a direct extracellular open channel blocker of voltage-gated potassium channels (IC50 = 307 nM for KV1.5) and abolishes IKr in ventricular myocytes (IC50 = 102.6 nM) independently of CaM kinase II inhibition. . Water soluble form and Negative Control also available.

catalog number base :

1278

product keywords :

K+ channel blockers KV inhibitors inhibits Potassium Channels voltage-gated voltage-dependent CaM Kinase II kinases Calmodulin-Activated calmodulin-dependent Protein Ca2+ Binding modulators Calcium Signaling Signalling hERG Human Ether-A-Go-Go Gene KCNQ K Calcium Binding Protein CaM Kinase Voltage-Gated Potassium Channels 1278,

extended description :

CaM kinase II inhibitor; also K+ channel blocker (KV)

chemical name text :

N-[2-[[[3-(4-Chlorophenyl)-2-propenyl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulphonamide

formula :

C 26 H 29 ClN 2 O 4 S

formula text :

C26H29ClN2O4S

cas num :

139298-40-1

2020 USD :

207

2021 USD :

216 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage