product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
1278/1
catalog :
1278/1
quantity :
1 mg
price :
271 USD
more info or order :
citations: 25
Reference
Weng Y, An R, Cassin J, Joseph J, Mi R, Wang C, et al. An Intrinsic Epigenetic Barrier for Functional Axon Regeneration. Neuron. 2017;94:337-346.e6 pubmed publisher
Abedini A, Zamberlam G, Lapointe E, Tourigny C, Boyer A, Paquet M, et al. WNT5a is required for normal ovarian follicle development and antagonizes gonadotropin responsiveness in granulosa cells by suppressing canonical WNT signaling. FASEB J. 2016;30:1534-47 pubmed publisher
Draganov D, Gopalakrishna Pillai S, Chen Y, Zuckerman N, Moeller S, Wang C, et al. Modulation of P2X4/P2X7/Pannexin-1 sensitivity to extracellular ATP via Ivermectin induces a non-apoptotic and inflammatory form of cancer cell death. Sci Rep. 2015;5:16222 pubmed publisher
Glovaci I, Chapman C. Activation of Phosphatidylinositol-Linked Dopamine Receptors Induces a Facilitation of Glutamate-Mediated Synaptic Transmission in the Lateral Entorhinal Cortex. PLoS ONE. 2015;10:e0131948 pubmed publisher
Cohen S, Li B, Tsien R, Ma H. Evolutionary and functional perspectives on signaling from neuronal surface to nucleus. Biochem Biophys Res Commun. 2015;460:88-99 pubmed publisher
Asghar M, Magnusson M, Kemppainen K, Sukumaran P, Löf C, Pulli I, et al. Transient Receptor Potential Canonical 1 (TRPC1) Channels as Regulators of Sphingolipid and VEGF Receptor Expression: IMPLICATIONS FOR THYROID CANCER CELL MIGRATION AND PROLIFERATION. J Biol Chem. 2015;290:16116-31 pubmed publisher
Raka F, Di Sebastiano A, Kulhawy S, Ribeiro F, Godin C, Caetano F, et al. Ca(2+)/calmodulin-dependent protein kinase II interacts with group I metabotropic glutamate and facilitates receptor endocytosis and ERK1/2 signaling: role of β-amyloid. Mol Brain. 2015;8:21 pubmed publisher
Galván E, Pérez Rosello T, Gómez Lira G, Lara E, Gutiérrez R, Barrionuevo G. Synapse-specific compartmentalization of signaling cascades for LTP induction in CA3 interneurons. Neuroscience. 2015;290:332-45 pubmed publisher
Bonnefond M, Lambert B, Giffard F, Abeilard E, Brotin E, Louis M, et al. Calcium signals inhibition sensitizes ovarian carcinoma cells to anti-Bcl-xL strategies through Mcl-1 down-regulation. Apoptosis. 2015;20:535-50 pubmed publisher
Nygaard V, Prasmickaite L, Vasiliauskaite K, Clancy T, Hovig E. Melanoma brain colonization involves the emergence of a brain-adaptive phenotype. Oncoscience. 2014;1:82-94 pubmed
Guemez Gamboa A, Xu L, Meng D, Spitzer N. Non-cell-autonomous mechanism of activity-dependent neurotransmitter switching. Neuron. 2014;82:1004-16 pubmed publisher
Hill B, Muldrew E. Oestrogen upregulates the sarcoplasmic reticulum Ca(2+) ATPase pump in coronary arteries. Clin Exp Pharmacol Physiol. 2014;41:430-6 pubmed publisher
Keats E, Dominguez J, Grant M, Khan Z. Switch from canonical to noncanonical Wnt signaling mediates high glucose-induced adipogenesis. Stem Cells. 2014;32:1649-60 pubmed publisher
Wang C, Held R, Hall B. SynGAP regulates protein synthesis and homeostatic synaptic plasticity in developing cortical networks. PLoS ONE. 2013;8:e83941 pubmed publisher
Bemben M, Shipman S, Hirai T, Herring B, Li Y, Badger J, et al. CaMKII phosphorylation of neuroligin-1 regulates excitatory synapses. Nat Neurosci. 2014;17:56-64 pubmed publisher
Arguello A, Hodges M, Wells A, Lara H, Xie X, Fuchs R. Involvement of amygdalar protein kinase A, but not calcium/calmodulin-dependent protein kinase II, in the reconsolidation of cocaine-related contextual memories in rats. Psychopharmacology (Berl). 2014;231:55-65 pubmed publisher
Seto S, Au A, Poon C, Zhang Q, Li R, Yeung J, et al. Acute simvastatin inhibits K ATP channels of porcine coronary artery myocytes. PLoS ONE. 2013;8:e66404 pubmed publisher
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Thayer D, Jan Y, Jan L. Increased neuronal activity fragments the Golgi complex. Proc Natl Acad Sci U S A. 2013;110:1482-7 pubmed publisher
El Gaamouch F, Buisson A, Moustié O, Lemieux M, Labrecque S, Bontempi B, et al. Interaction between ?CaMKII and GluN2B controls ERK-dependent plasticity. J Neurosci. 2012;32:10767-79 pubmed publisher
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Marsden K, Beattie J, Friedenthal J, Carroll R. NMDA receptor activation potentiates inhibitory transmission through GABA receptor-associated protein-dependent exocytosis of GABA(A) receptors. J Neurosci. 2007;27:14326-37 pubmed
product information
master code :
1278
SKU :
1278/1
product name :
KN 93
unit size :
1 mg
description :
CaM kinase II inhibitor; also K+ channel blocker (KV)
target :
Calcium Binding Protein Modulator Inhibitors
category :
Small Molecules
purity :
98%
observed molecular weight :
501.04
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
KN 93 is a potent, cell permeable inhibitor of CaM kinase II (IC50 = 0.37 M). Also a direct extracellular open channel blocker of voltage-gated potassium channels (IC50 = 307 nM for KV1.5) and abolishes IKr in ventricular myocytes (IC50 = 102.6 nM) independently of CaM kinase II inhibition. . Water soluble form and Negative Control also available.
top caption :
CaM kinase II inhibitor; also K+ channel blocker (KV)
extended description :
CaM kinase II inhibitor; also K+ channel blocker (KV)
chemical name text :
N-[2-[[[3-(4-Chlorophenyl)-2-propenyl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulphonamide
formula :
C26H29ClN2O4S
formula text :
C26H29ClN2O4S
cas num :
139298-40-1
USD :
271 USD
product details :
CaM kinase II inhibitor; also K+ channel blocker (KV)
storage :
Store at +4░C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK