product summary
Loading...
company name :
Tocris Bioscience
product type :
chemical
product name :
1276/10
catalog :
1276/10
quantity :
10 mg (also 50 mg)
price :
232 USD
more info or order :
citations: 24
Reference |
---|
Breshears L, Schlievert P, Peterson M. A disintegrin and metalloproteinase 17 (ADAM17) and epidermal growth factor receptor (EGFR) signaling drive the epithelial response to Staphylococcus aureus toxic shock syndrome toxin-1 (TSST-1). J Biol Chem. 2012;287:32578-87 pubmed
|
Fang Y, Ferrie A, Fontaine N, Mauro J, Balakrishnan J. Resonant waveguide grating biosensor for living cell sensing. Biophys J. 2006;91:1925-40 pubmed
|
Belcher S, Le H, Spurling L, Wong J. Rapid estrogenic regulation of extracellular signal- regulated kinase 1/2 signaling in cerebellar granule cells involves a G protein- and protein kinase A-dependent mechanism and intracellular activation of protein phosphatase 2A. Endocrinology. 2005;146:5397-406 pubmed
|
Maggiolini M, Vivacqua A, Fasanella G, Recchia A, Sisci D, Pezzi V, et al. The G protein-coupled receptor GPR30 mediates c-fos up-regulation by 17beta-estradiol and phytoestrogens in breast cancer cells. J Biol Chem. 2004;279:27008-16 pubmed
|
Atherton H, Jones G, Danahay H. IL-13-induced changes in the goblet cell density of human bronchial epithelial cell cultures: MAP kinase and phosphatidylinositol 3-kinase regulation. Am J Physiol Lung Cell Mol Physiol. 2003;285:L730-9 pubmed
|
product information
master code :
1276
SKU :
1276/10
product name :
AG 1478 hydrochloride
unit size :
10 mg (also 50 mg)
description :
Highly potent EGFR-kinase inhibitor
target :
EGF Receptor Inhibitors
category :
Small Molecules
purity :
98%
observed molecular weight :
352.22
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
AG 1478 hydrochloride is a potent and selective inhibitor of epidermal growth factor receptor kinase (IC50 values 3 nM for EGFR and 100 u M for ErbB2 and PDGFR). Inhibits proliferation of NCI-H2170 NSCLC cells in vitro (IC50 = 1 M).
top caption :
Highly potent EGFR-kinase inhibitor
extended description :
Highly potent EGFR-kinase inhibitor
chemical name text :
N-(3-Chlorophenyl)-6,7-dimethoxy-4-quinazolinanine hydrochloride
formula :
C16H14ClN3O2.HCl
formula text :
C16H14ClN3O2.HCl
cas num :
170449-18-0
USD :
232 USD
product details :
Highly potent EGFR-kinase inhibitor
alt names :
Tyrphostin AG 1478
storage :
Desiccate at -20░C
more info or order :
company information

Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com800-343-7475
headquarters: UK
related products
browse more products
questions and comments