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company name :
Tocris Bioscience
product type :
chemical
product name :
1276/10
catalog :
1276/10
quantity :
10 mg (also 50 mg)
price :
232 USD
more info or order :
citations: 24
Reference
Koeppen M, Lee J, Seo S, Brodsky K, Kreth S, Yang I, et al. Hypoxia-inducible factor 2-alpha-dependent induction of amphiregulin dampens myocardial ischemia-reperfusion injury. Nat Commun. 2018;9:816 pubmed publisher
Hosseini Z, Nelson D, Moskwa N, Sfakis L, Castracane J, Larsen M. FGF2-dependent mesenchyme and laminin-111 are niche factors in salivary gland organoids. J Cell Sci. 2018;131: pubmed publisher
Huang B, Chen T, Bau D, Chuang I, Tsai C, Chang P, et al. EGFR is a pivotal regulator of thrombin-mediated inflammation in primary human nucleus pulposus culture. Sci Rep. 2017;7:8578 pubmed publisher
Gillman A, Breshears L, Kistler C, Finnegan P, Torres V, Schlievert P, et al. Epidermal Growth Factor Receptor Signaling Enhances the Proinflammatory Effects of Staphylococcus aureus Gamma-Toxin on the Mucosa. Toxins (Basel). 2017;9: pubmed publisher
Zhu J, Li K, Cao S, Chen X, Shen C, Zhang Y, et al. Increased NRG1-ErbB4 signaling in human symptomatic epilepsy. Sci Rep. 2017;7:141 pubmed publisher
Martin R, Cordova C, Gutierrez B, Hernández M, Nieto M. A dangerous liaison: Leptin and sPLA2-IIA join forces to induce proliferation and migration of astrocytoma cells. PLoS ONE. 2017;12:e0170675 pubmed publisher
Leonetti C, Macrez R, Pruvost M, Hommet Y, Bronsard J, Fournier A, et al. Tissue-type plasminogen activator exerts EGF-like chemokinetic effects on oligodendrocytes in white matter (re)myelination. Mol Neurodegener. 2017;12:20 pubmed publisher
Breshears L, Gillman A, Stach C, Schlievert P, Peterson M. Local Epidermal Growth Factor Receptor Signaling Mediates the Systemic Pathogenic Effects of Staphylococcus aureus Toxic Shock Syndrome. PLoS ONE. 2016;11:e0158969 pubmed publisher
Bertrand T, Lesept F, Chevilley A, Lenoir S, Aimable M, Briens A, et al. Conformations of tissue plasminogen activator (tPA) orchestrate neuronal survival by a crosstalk between EGFR and NMDAR. Cell Death Dis. 2015;6:e1924 pubmed publisher
Mathew L, Huangyang P, Mucaj V, Lee S, Skuli N, Eisinger Mathason T, et al. Feedback circuitry between miR-218 repression and RTK activation in glioblastoma. Sci Signal. 2015;8:ra42 pubmed publisher
Ledonne A, Nobili A, Latagliata E, Cavallucci V, Guatteo E, Puglisi Allegra S, et al. Neuregulin 1 signalling modulates mGluR1 function in mesencephalic dopaminergic neurons. Mol Psychiatry. 2015;20:959-73 pubmed publisher
Pandya C, Pillai A. TrkB interacts with ErbB4 and regulates NRG1-induced NR2B phosphorylation in cortical neurons before synaptogenesis. Cell Commun Signal. 2014;12:47 pubmed publisher
Bayliss A, Evans P. Characterisation of AmphiAmR11, an amphioxus (Branchiostoma floridae) D2-dopamine-like G protein-coupled receptor. PLoS ONE. 2013;8:e80833 pubmed publisher
Voon D, Wang H, Koo J, Chai J, Hor Y, Tan T, et al. EMT-induced stemness and tumorigenicity are fueled by the EGFR/Ras pathway. PLoS ONE. 2013;8:e70427 pubmed publisher
Akhtar S, Yousif M, Dhaunsi G, Sarkhouh F, Chandrasekhar B, Attur S, et al. Activation of ErbB2 and Downstream Signalling via Rho Kinases and ERK1/2 Contributes to Diabetes-Induced Vascular Dysfunction. PLoS ONE. 2013;8:e67813 pubmed publisher
Ayoub M, See H, Seeber R, Armstrong S, Pfleger K. Profiling epidermal growth factor receptor and heregulin receptor 3 heteromerization using receptor tyrosine kinase heteromer investigation technology. PLoS ONE. 2013;8:e64672 pubmed publisher
Zhang X, Meng J, Wang Z. A switch role of Src in the biphasic EGF signaling of ER-negative breast cancer cells. PLoS ONE. 2012;7:e41613 pubmed publisher
Breshears L, Schlievert P, Peterson M. A disintegrin and metalloproteinase 17 (ADAM17) and epidermal growth factor receptor (EGFR) signaling drive the epithelial response to Staphylococcus aureus toxic shock syndrome toxin-1 (TSST-1). J Biol Chem. 2012;287:32578-87 pubmed
Lee E, Sidoryk Wegrzynowicz M, Wang N, Webb A, Son D, Lee K, et al. GPR30 regulates glutamate transporter GLT-1 expression in rat primary astrocytes. J Biol Chem. 2012;287:26817-28 pubmed publisher
O Keeffe G, Tyers P, Aarsland D, Dalley J, Barker R, Caldwell M. Dopamine-induced proliferation of adult neural precursor cells in the mammalian subventricular zone is mediated through EGF. Proc Natl Acad Sci U S A. 2009;106:8754-9 pubmed publisher
Fang Y, Ferrie A, Fontaine N, Mauro J, Balakrishnan J. Resonant waveguide grating biosensor for living cell sensing. Biophys J. 2006;91:1925-40 pubmed
Belcher S, Le H, Spurling L, Wong J. Rapid estrogenic regulation of extracellular signal- regulated kinase 1/2 signaling in cerebellar granule cells involves a G protein- and protein kinase A-dependent mechanism and intracellular activation of protein phosphatase 2A. Endocrinology. 2005;146:5397-406 pubmed
Maggiolini M, Vivacqua A, Fasanella G, Recchia A, Sisci D, Pezzi V, et al. The G protein-coupled receptor GPR30 mediates c-fos up-regulation by 17beta-estradiol and phytoestrogens in breast cancer cells. J Biol Chem. 2004;279:27008-16 pubmed
Atherton H, Jones G, Danahay H. IL-13-induced changes in the goblet cell density of human bronchial epithelial cell cultures: MAP kinase and phosphatidylinositol 3-kinase regulation. Am J Physiol Lung Cell Mol Physiol. 2003;285:L730-9 pubmed
product information
master code :
1276
SKU :
1276/10
product name :
AG 1478 hydrochloride
unit size :
10 mg (also 50 mg)
description :
Highly potent EGFR-kinase inhibitor
target :
EGF Receptor Inhibitors
category :
Small Molecules
purity :
98%
observed molecular weight :
352.22
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
AG 1478 hydrochloride is a potent and selective inhibitor of epidermal growth factor receptor kinase (IC50 values 3 nM for EGFR and 100 u M for ErbB2 and PDGFR). Inhibits proliferation of NCI-H2170 NSCLC cells in vitro (IC50 = 1 M).
top caption :
Highly potent EGFR-kinase inhibitor
extended description :
Highly potent EGFR-kinase inhibitor
chemical name text :
N-(3-Chlorophenyl)-6,7-dimethoxy-4-quinazolinanine hydrochloride
formula :
C16H14ClN3O2.HCl
formula text :
C16H14ClN3O2.HCl
cas num :
170449-18-0
USD :
232 USD
product details :
Highly potent EGFR-kinase inhibitor
alt names :
Tyrphostin AG 1478
storage :
Desiccate at -20░C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK