PD 150606 | Tocris Bioscience 1269 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

PD 150606

catalog :

1269

quantity :

10 mg (also 50 mg)

price :

173 USD

more info or order :

Tocris Bioscience product webpage

citations: 6

Reference
Chang T, Chen C, Lee M, Chang Y, Lu C, Lu S, et al. Paxillin facilitates timely neurite initiation on soft-substrate environments by interacting with the endocytic machinery. elife. 2017;6: pubmed publisher
Alvarez Arce A, Lee Rivera I, Lopez E, Hernandez Cruz A, López Colomé A. Thrombin-Induced Calpain Activation Promotes Protease-Activated Receptor 1 Internalization. Int J Cell Biol. 2017;2017:1908310 pubmed publisher
Pradhan A, Hammerquist A, Khanna A, Curran S. The C-Box Region of MAF1 Regulates Transcriptional Activity and Protein Stability. J Mol Biol. 2017;429:192-207 pubmed publisher
Getz A, Visser F, Bell E, Xu F, Flynn N, Zaidi W, et al. Two proteolytic fragments of menin coordinate the nuclear transcription and postsynaptic clustering of neurotransmitter receptors during synaptogenesis between Lymnaea neurons. Sci Rep. 2016;6:31779 pubmed publisher
Bill A, Gutierrez A, Kulkarni S, Kemp C, Bonenfant D, Voshol H, et al. ANO1/TMEM16A interacts with EGFR and correlates with sensitivity to EGFR-targeting therapy in head and neck cancer. Oncotarget. 2015;6:9173-88 pubmed
Chamma I, Heubl M, Chevy Q, Renner M, Moutkine I, Eugène E, et al. Activity-dependent regulation of the K/Cl transporter KCC2 membrane diffusion, clustering, and function in hippocampal neurons. J Neurosci. 2013;33:15488-503 pubmed publisher

product information

brand :

Tocris

master code :

1269

SKU :

1269/10

product name :

PD 150606

description :

Cell permeable calpain inhibitor

target :

Calpain Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

95%

observed molecular weight :

306.12

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Selective, cell-permeable non-peptide calpain inhibitor (Ki values for and m-calpains are 0.21 and 0.37 M respectively). Targets the calcium binding sites of calpain. Demonstrates high specificity for calpains relative to other proteases, and is a non-competitive inhibitor with respect to the substrate.

catalog number base :

1269

product keywords :

PD150606 calpain inhibitors inhibits selective Ca2+Sensitive Protease modulators Calcium-Sensitive Ca2+ Signaling Signalling Proteinases Proteases Calcium-Sensitive Proteases Calpains 1269,

extended description :

Cell permeable calpain inhibitor

chemical name text :

(Z)-3-(4-Iodophenyl)-2-mercapto-2-propenoic acid

formula :

C 9 H 7 IO 2 S

formula text :

C9H7IO2S

cas num :

179528-45-1

2020 USD :

166

2021 USD :

173 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage