Pifithrin-a hydrobromide | Tocris Bioscience 1267 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Pifithrin-a hydrobromide

catalog :

1267

quantity :

10 mg (also 50 mg)

price :

173 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Li H, Zhang J, Niswander L. Zinc deficiency causes neural tube defects through attenuation of p53 ubiquitylation. Development. 2018;145: pubmed publisher
Norlin S, Parekh V, Edlund H. The ATPase activity of Asna1/TRC40 is required for pancreatic progenitor cell survival. Development. 2018;145: pubmed publisher
Guha G, Lu W, Li S, Liang X, Kulesz Martin M, Mahmud T, et al. Novel Pactamycin Analogs Induce p53 Dependent Cell-Cycle Arrest at S-Phase in Human Head and Neck Squamous Cell Carcinoma (HNSCC) Cells. PLoS ONE. 2015;10:e0125322 pubmed publisher
Fraser M, Chan S, Chan S, Fiscus R, Tsang B. Regulation of p53 and suppression of apoptosis by the soluble guanylyl cyclase/cGMP pathway in human ovarian cancer cells. Oncogene. 2006;25:2203-12 pubmed

product information

brand :

Tocris

master code :

1267

SKU :

1267/10

product name :

Pifithrin-a hydrobromide

description :

p53 inhibitor. Also aryl hydrocarbon receptor agonist

target :

p53 Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

observed molecular weight :

367.3

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Inhibitor of p53; reversibly blocks p53-dependent transcriptional activation and apoptosis. Protects against neuronal death in models of stroke and neurodegenerative disorders. Active in vivo ; protects mice from the side-effects of cancer therapy associated with p53 induction. Supresses self-renewal of embryonic stem cells. Also aryl hydrocarbon receptor (AHR) agonist, causes upregulation of AHR target gene CYP1A1 (EC50 = 1.1 u M). Cyclic analog available (Cat. No. 3843).

catalog number base :

1267

product keywords :

p53 inhibitors inhibits aryl hydrocarbon receptors agonists AHR Transcription Factors Pifithrin-alpha hydrobromide p53 Aryl Hydrocarbon Receptors Stem Cell Signaling Autophagy 1267,

extended description :

p53 inhibitor. Also aryl hydrocarbon receptor agonist

chemical name text :

1-(4-Methylphenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)-benzothiazolyl)ethanone hydrobromide

formula :

C 16 H 18 N 2 OS.HBr

formula text :

C16H18N2OS.HBr

cas num :

63208-82-2

2020 USD :

166

2021 USD :

173 USD

storage :

Desiccate at -20°C

more info or order :

Tocris Bioscience product webpage