1267/10 | Tocris Bioscience 1267/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

1267/10

catalog :

1267/10

quantity :

10 mg (also 50 mg)

price :

223 USD

more info or order :

Tocris Bioscience product webpage

citations: 7

Reference
Li H, Zhang J, Niswander L. Zinc deficiency causes neural tube defects through attenuation of p53 ubiquitylation. Development. 2018;145: pubmed publisher
Huang T, Huang X, Shi B, Wang F, Feng W, Yao M. Regulators of Salmonella-host interaction identified by peripheral blood transcriptome profiling: roles of TGFB1 and TRP53 in intracellular Salmonella replication in pigs. Vet Res. 2018;49:121 pubmed publisher
Yang L, Li Y, Bhattacharya A, Zhang Y. PEPD is a pivotal regulator of p53 tumor suppressor. Nat Commun. 2017;8:2052 pubmed publisher
Norlin S, Parekh V, Edlund H. The ATPase activity of Asna1/TRC40 is required for pancreatic progenitor cell survival. Development. 2018;145: pubmed publisher
Guha G, Lu W, Li S, Liang X, Kulesz Martin M, Mahmud T, et al. Novel Pactamycin Analogs Induce p53 Dependent Cell-Cycle Arrest at S-Phase in Human Head and Neck Squamous Cell Carcinoma (HNSCC) Cells. PLoS ONE. 2015;10:e0125322 pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Fraser M, Chan S, Chan S, Fiscus R, Tsang B. Regulation of p53 and suppression of apoptosis by the soluble guanylyl cyclase/cGMP pathway in human ovarian cancer cells. Oncogene. 2006;25:2203-12 pubmed

product information

master code :

1267

SKU :

1267/10

product name :

Pifithrin-a hydrobromide

unit size :

10 mg (also 50 mg)

description :

p53 inhibitor. Also aryl hydrocarbon receptor agonist

target :

p53 Inhibitors

category :

Small Molecules

observed molecular weight :

367.3

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Pifithrin- hydrobromide is an inhibitor of p53; reversibly blocks p53-dependent transcriptional activation and apoptosis. Protects against neuronal death in models of stroke and neurodegenerative disorders. Active in vivo ; protects mice from the side-effects of cancer therapy associated with p53 induction. Supresses self-renewal of embryonic stem cells. Also aryl hydrocarbon receptor (AHR) agonist, causes upregulation of AHR target gene CYP1A1 (EC50 = 1.1 u M). Cyclic analog available (Cat. No. 3843).

top caption :

p53 inhibitor. Also aryl hydrocarbon receptor agonist

extended description :

p53 inhibitor. Also aryl hydrocarbon receptor agonist

chemical name text :

1-(4-Methylphenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)-benzothiazolyl)ethanone hydrobromide

formula :

C16H18N2OS.HBr

formula text :

C16H18N2OS.HBr

cas num :

63208-82-2

USD :

223 USD

product details :

p53 inhibitor. Also aryl hydrocarbon receptor agonist

storage :

Desiccate at -20░C

more info or order :

Tocris Bioscience product webpage