product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
1263/10
catalog :
1263/10
quantity :
10 mg (also 50 mg)
price :
228 USD
more info or order :
citations: 6
Reference
Pavlou S, Foskolou S, Patikas N, Field S, Papachristou E, Santos C, et al. CRISPR-Cas9 genetic screen leads to the discovery of L-Moses, a KAT2B inhibitor that attenuates Tunicamycin-mediated neuronal cell death. Sci Rep. 2023;13:3934 pubmed publisher
Puhr Westerheide D, Schink S, Fabritius M, Mittmann L, Hessenauer M, Pircher J, et al. Neutrophils promote venular thrombosis by shaping the rheological environment for platelet aggregation. Sci Rep. 2019;9:15932 pubmed publisher
Lee M, Verni C, Herbig B, Diamond S. Soluble fibrin causes an acquired platelet glycoprotein VI signaling defect: implications for coagulopathy. J Thromb Haemost. 2017;: pubmed publisher
Badolia R, Inamdar V, Manne B, Dangelmaier C, Eble J, Kunapuli S. Gq pathway regulates proximal C-type lectin-like receptor-2 (CLEC-2) signaling in platelets. J Biol Chem. 2017;292:14516-14531 pubmed publisher
Le Béhot A, Gauberti M, Martinez de Lizarrondo S, Montagne A, Lemarchand E, Repesse Y, et al. GpIb?-VWF blockade restores vessel patency by dissolving platelet aggregates formed under very high shear rate in mice. Blood. 2014;123:3354-63 pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
product information
master code :
1263
SKU :
1263/10
product name :
GR 144053 trihydrochloride
unit size :
10 mg (also 50 mg)
description :
Glycoprotein IIb/IIIa (integrin IIb 3) receptor antagonist. Antithrombotic
target :
Integrin Receptor Inhibitors
category :
Small Molecules
purity :
99%
observed molecular weight :
454.83
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
GR 144053 trihydrochloride is a potent and selective platelet fibrinogen receptor glycoprotein IIb/IIIa (GpIIb/IIIa) antagonist (IC50 = 37 nM). Orally active and highly effective at inhibiting thrombus formation in vivo .
top caption :
Glycoprotein IIb/IIIa (integrin IIb 3) receptor antagonist. Antithrombotic
extended description :
Glycoprotein IIb/IIIa (integrin IIb 3) receptor antagonist. Antithrombotic
chemical name text :
4-[4-[4-(Aminoiminomethyl)phenyl]-1-piperazinyl]-1-piperidineacetic acid trihydrochloride
formula :
C18H27N5O2.3HCl
formula text :
C18H27N5O2.3HCl
cas num :
1215333-48-4
USD :
228 USD
product details :
Glycoprotein IIb/IIIa (integrin IIb 3) receptor antagonist. Antithrombotic
storage :
Desiccate at +4░C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK