1261/10 | Tocris Bioscience 1261/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

1261/10

catalog :

1261/10

quantity :

10 mg (also 50 mg)

price :

126 USD

more info or order :

Tocris Bioscience product webpage

citations: 11

Reference
Xiao C, Liu N, Jacobson K, Gavrilova O, Reitman M. Physiology and effects of nucleosides in mice lacking all four adenosine receptors. PLoS Biol. 2019;17:e3000161 pubmed publisher
Davidson J, Urban T, Tong S, Twite M, Woodruff A, Wischmeyer P, et al. Alkaline Phosphatase, Soluble Extracellular Adenine Nucleotides, and Adenosine Production after Infant Cardiopulmonary Bypass. PLoS ONE. 2016;11:e0158981 pubmed publisher
Yu Y, Guerrero C, Liu S, Amato N, Sharma Y, Gupta S, et al. Comprehensive Assessment of Oxidatively Induced Modifications of DNA in a Rat Model of Human Wilson's Disease. Mol Cell Proteomics. 2016;15:810-7 pubmed publisher
Li G, Nakagome I, Hirono S, Itoh T, Fujiwara R. Inhibition of adenosine deaminase (ADA)-mediated metabolism of cordycepin by natural substances. Pharmacol Res Perspect. 2015;3:e00121 pubmed publisher
Liu S, Dunwell T, Pfeifer G, Dunwell J, Ullah I, Wang Y. Detection of oxidation products of 5-methyl-2'-deoxycytidine in Arabidopsis DNA. PLoS ONE. 2013;8:e84620 pubmed publisher
Guerrero C, Wang J, Wang Y. Induction of 8,5'-cyclo-2'-deoxyadenosine and 8,5'-cyclo-2'-deoxyguanosine in isolated DNA by Fenton-type reagents. Chem Res Toxicol. 2013;26:1361-6 pubmed publisher
Lindquist B, Shuttleworth C. Adenosine receptor activation is responsible for prolonged depression of synaptic transmission after spreading depolarization in brain slices. Neuroscience. 2012;223:365-76 pubmed publisher
Prakasam H, Herrington H, Roppolo J, Jackson E, Apodaca G. Modulation of bladder function by luminal adenosine turnover and A1 receptor activation. Am J Physiol Renal Physiol. 2012;303:F279-92 pubmed publisher
Takahashi T, Otsuguro K, Ohta T, Ito S. Adenosine and inosine release during hypoxia in the isolated spinal cord of neonatal rats. Br J Pharmacol. 2010;161:1806-16 pubmed publisher
Yang A, Mucsi A, Desrosiers M, Chen J, Schnermann J, Blackburn M, et al. Adenosine mediated desensitization of cAMP signaling enhances T-cell responses. Eur J Immunol. 2010;40:449-59 pubmed publisher
Uckert S, Kuthe A, Jonas U, Stief C. Characterization and functional relevance of cyclic nucleotide phosphodiesterase isoenzymes of the human prostate. J Urol. 2001;166:2484-90 pubmed

product information

master code :

1261

SKU :

1261/10

product name :

EHNA hydrochloride

unit size :

10 mg (also 50 mg)

description :

Adenosine deaminase inhibitor

target :

Deaminase Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

313.83

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

EHNA hydrochloride is a selective inhibitor of cGMP-stimulated phosphodiesterase (PDE2) (IC50 = 0.8 - 4 M). Also a potent inhibitor of adenosine deaminase. Suppresses spontaneous differentiation of human ESCs in feeder-free conditions. Also prevents directed neuronal differentiation.

top caption :

Adenosine deaminase inhibitor

extended description :

Adenosine deaminase inhibitor

chemical name text :

erythro-9-(2-Hydroxy-3-nonyl)adenine hydrochloride

formula :

C14H23N5O.HCl

formula text :

C14H23N5O.HCl

cas num :

58337-38-5

USD :

126 USD

product details :

Adenosine deaminase inhibitor

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage