Ivermectin | Tocris Bioscience 1260 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Ivermectin

catalog :

1260

quantity :

100 mg

price :

75 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Dhuna K, Felgate M, Bidula S, Walpole S, Bibic L, Cromer B, et al. Ginsenosides Act As Positive Modulators of P2X4 Receptors. Mol Pharmacol. 2019;95:210-221 pubmed publisher
Dolma S, Selvadurai H, Lan X, Lee L, Kushida M, Voisin V, et al. Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem Cells. Cancer Cell. 2016;29:859-873 pubmed publisher
Ren M, Du C, Herrero Acero E, Tang Schomer M, Ozkucur N. A biofidelic 3D culture model to study the development of brain cellular systems. Sci Rep. 2016;6:24953 pubmed publisher
Fischer W, Urban N, Immig K, Franke H, Schaefer M. Natural compounds with P2X7 receptor-modulating properties. Purinergic Signal. 2014;10:313-26 pubmed publisher
Nörenberg W, Sobottka H, Hempel C, Plötz T, Fischer W, Schmalzing G, et al. Positive allosteric modulation by ivermectin of human but not murine P2X7 receptors. Br J Pharmacol. 2012;167:48-66 pubmed publisher

product information

brand :

Tocris

master code :

1260

SKU :

1260/100

product name :

Ivermectin

description :

Positive allosteric modulator of 7 nAChRs; also positive allosteric modulator of P2X4 receptors

target :

Nicotinic (a7) Receptor Modulators

category :

Small Molecules

unit size :

100 mg

purity :

96%

observed molecular weight :

875.1

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Positive allosteric modulator of the 7 neuronal nicotinic acetylcholine receptor and the purinergic P2X4 receptor. Antihelmintic and antiviral. Also modulates glutamate- and GABA-activated chloride channels. Potentiates glycine-gated currents at low concentrations (30 nM). Inhibits replication of SARS-CoV-2 in vitro (IC50 ~ 2 M). . This product is composed of both Ivermectin B1a (>90%) and Ivermectin B1b.

catalog number base :

1260

product keywords :

Allosteric modulators 7 alpha7 nicotinic receptors Positive allosteric P2X4 Acetylcholine nAChR Purinergic purinoceptors PAM SARS-CoV-2 COVID-19 antiviral antiparasitic P2X Receptors Nicotinic (a7) Receptors COVID-19 Coronavirus 1260,

extended description :

Positive allosteric modulator of 7 nAChRs; also positive allosteric modulator of P2X4 receptors

chemical name text :

22,23-Dihydroavermectin B1

formula :

C 48 H 74 O 14 (B 1 a form)

formula text :

C48H74O14 (B1a form)

cas num :

70288-86-7

2020 USD :

2021 USD :

75 USD

storage :

Desiccate at +4°C

more info or order :

Tocris Bioscience product webpage