product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
Y-27632 dihydrochloride
catalog :
1254
quantity :
1 mg (also 10 mg, 50 mg)
price :
132 USD
more info or order :
citations: 243
Reference
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product information
brand :
Tocris
master code :
1254
SKU :
1254/1
product name :
Y-27632 dihydrochloride
description :
Selective ROCK inhibitor; inhibits ROCK1 (p160 ROCK) and ROCK2; stem cell freezing (cryopreservation) media component
target :
Rho-kinase Inhibitors
category :
Small Molecules
unit size :
1 mg (also 10 mg, 50 mg)
purity :
98%
observed molecular weight :
320.26
url print :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Selective ROCK inhibitor (Ki values are 0.14-0.22, 0.3, 25, 26 and 250 M for ROCK1 (p160 ROCK), ROCK2, PKA, PKC and MLCK respectively). Also inhibits PRK2 (IC50 = 600 nM). Increases survival rate of human embryonic stem (hES) cells and iPSC undergoing cryopreservation. Used in combination with CHIR99021, RepSox, Forskolin, SP 600125, Go 6983 and VPA to reprogram fibroblasts to mature neurons. Also optimizes naive human pluripotent stem cell growth and viability following naive cell derivation from primed ESCs and iPSCs using naive human stem cell medium (NHSM). Used as component of growth media for urothelial organoids. Cell-permeable, orally bioavailable and active in vivo . . Y-27632 synthesized to cGMP guidelines also available.
catalog number base :
1254
product keywords :
Selective p160 ROCK inhibitors inhibits Rho-Kinase Rho-Associated Coiled-Coil Kinases ROK stem cells organoids induced pluripotent ROCKI ROCK1 ROCKII ROCK2 reprogramming cryopreservation differentiation cell freezing media 2HCl Rho-kinases Stem Cell Proliferation Organoids Stem Cell Reprogramming Neural Stem Cells 1254,
extended description :
Selective ROCK inhibitor; inhibits ROCK1 (p160 ROCK) and ROCK2; stem cell freezing (cryopreservation) media component
chemical name text :
trans-4-[(1R)-1-Aminoethyl]-N-4-pyridinylcyclohexanecarboxamide dihydrochloride
formula :
C 14 H 21 N 3 O.2HCl
formula text :
C14H21N3O.2HCl
cas num :
129830-38-2
2020 USD :
125
2021 USD :
132 USD
storage :
Desiccate at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK