(S)-WAY 100135 dihydrochloride | Tocris Bioscience 1253 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

(S)-WAY 100135 dihydrochloride

catalog :

1253

quantity :

10 mg (also 50 mg)

price :

169 USD

more info or order :

Tocris Bioscience product webpage

citations: 6

Reference
Saxena S, Roselli F, Singh K, Leptien K, Julien J, Gros Louis F, et al. Neuroprotection through excitability and mTOR required in ALS motoneurons to delay disease and extend survival. Neuron. 2013;80:80-96 pubmed publisher
Pandya A, Yakel J. Activation of the Î±7 nicotinic ACh receptor induces anxiogenic effects in rats which is blocked by a 5-HTâ‚a receptor antagonist. Neuropharmacology. 2013;70:35-42 pubmed publisher
Grace K, Liu H, Horner R. 5-HT1A receptor-responsive pedunculopontine tegmental neurons suppress REM sleep and respiratory motor activity. J Neurosci. 2012;32:1622-33 pubmed publisher
Chambers J, Bornstein J, Thomas E. Multiple neural oscillators and muscle feedback are required for the intestinal fed state motor program. PLoS ONE. 2011;6:e19597 pubmed publisher
Foong J, Parry L, Gwynne R, Bornstein J. 5-HT(1A), SST(1), and SST(2) receptors mediate inhibitory postsynaptic potentials in the submucous plexus of the guinea pig ileum. Am J Physiol Gastrointest Liver Physiol. 2010;298:G384-94 pubmed publisher
Hampson L, Mackin P, Agius L. Stimulation of glycogen synthesis and inactivation of phosphorylase in hepatocytes by serotonergic mechanisms, and counter-regulation by atypical antipsychotic drugs. Diabetologia. 2007;50:1743-51 pubmed

product information

brand :

Tocris

master code :

1253

SKU :

1253/10

product name :

(S)-WAY 100135 dihydrochloride

description :

Potent and selective 5-HT1A antagonist

target :

5-HT1A Receptor Antagonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

468.47

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent, selective 5-HT1A receptor antagonist (IC50 = 15 nM). Selective over 5-HT1B, 1C, 2, 1, 2 and D2 receptors (IC50 1000 nM). Centrally active on systemic administration.

catalog number base :

1253

product keywords :

Potent selective 5-HT1A antagonist Serotonin Receptors (S)-WAY100135 dihydrochloride 5-HT1A Receptors 1253,

extended description :

Potent and selective 5-HT1A antagonist

chemical name text :

(S)-N-tert-Butyl-3-(4-(2-methoxyphenyl)-piperazin-1-yl)-2-phenylpropanamide dihydrochloride

formula :

C 24 H 33 N 3 O 2 .2HCl

formula text :

C24H33N3O2.2HCl

cas num :

149007-54-5

2020 USD :

162

2021 USD :

169 USD

storage :

Desiccate at +4°C

more info or order :

Tocris Bioscience product webpage