product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
1253/10
catalog :
1253/10
quantity :
10 mg (also 50 mg)
price :
217 USD
more info or order :
citations: 6
Reference
Saxena S, Roselli F, Singh K, Leptien K, Julien J, Gros Louis F, et al. Neuroprotection through excitability and mTOR required in ALS motoneurons to delay disease and extend survival. Neuron. 2013;80:80-96 pubmed publisher
Pandya A, Yakel J. Activation of the α7 nicotinic ACh receptor induces anxiogenic effects in rats which is blocked by a 5-HT₁a receptor antagonist. Neuropharmacology. 2013;70:35-42 pubmed publisher
Grace K, Liu H, Horner R. 5-HT1A receptor-responsive pedunculopontine tegmental neurons suppress REM sleep and respiratory motor activity. J Neurosci. 2012;32:1622-33 pubmed publisher
Chambers J, Bornstein J, Thomas E. Multiple neural oscillators and muscle feedback are required for the intestinal fed state motor program. PLoS ONE. 2011;6:e19597 pubmed publisher
Foong J, Parry L, Gwynne R, Bornstein J. 5-HT(1A), SST(1), and SST(2) receptors mediate inhibitory postsynaptic potentials in the submucous plexus of the guinea pig ileum. Am J Physiol Gastrointest Liver Physiol. 2010;298:G384-94 pubmed publisher
Hampson L, Mackin P, Agius L. Stimulation of glycogen synthesis and inactivation of phosphorylase in hepatocytes by serotonergic mechanisms, and counter-regulation by atypical antipsychotic drugs. Diabetologia. 2007;50:1743-51 pubmed
product information
master code :
1253
SKU :
1253/10
product name :
(S)-WAY 100135 dihydrochloride
unit size :
10 mg (also 50 mg)
description :
Potent and selective 5-HT1A antagonist
target :
5-HT1A Receptor Antagonists
category :
Small Molecules
purity :
99%
observed molecular weight :
468.47
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
( S )-WAY 100135 dihydrochloride is a potent, selective 5-HT1A receptor antagonist (IC50 = 15 nM). Selective over 5-HT1B, 1C, 2, 1, 2 and D2 receptors (IC50 1000 nM). Centrally active on systemic administration.
top caption :
Potent and selective 5-HT1A antagonist
extended description :
Potent and selective 5-HT1A antagonist
chemical name text :
(S)-N-tert-Butyl-3-(4-(2-methoxyphenyl)-piperazin-1-yl)-2-phenylpropanamide dihydrochloride
formula :
C24H33N3O2.2HCl
formula text :
C24H33N3O2.2HCl
cas num :
149007-54-5
USD :
217 USD
product details :
Potent and selective 5-HT1A antagonist
storage :
Desiccate at +4░C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK