product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
1246/10
catalog :
1246/10
quantity :
10 mg (also 50 mg)
price :
296 USD
more info or order :
citations: 23
Reference
Vergassola M, Olivero G, Cisani F, Usai C, Bossi S, Puliti A, et al. Presynaptic mGlu1 Receptors Control GABAB Receptors in an Antagonist-Like Manner in Mouse Cortical GABAergic and Glutamatergic Nerve Endings. Front Mol Neurosci. 2018;11:324 pubmed publisher
Sargin D, Oliver D, Lambe E. Chronic social isolation reduces 5-HT neuronal activity via upregulated SK3 calcium-activated potassium channels. elife. 2016;5: pubmed publisher
Kim K, Ramiro Diaz J, Iddings J, Filosa J. Vasculo-Neuronal Coupling: Retrograde Vascular Communication to Brain Neurons. J Neurosci. 2016;36:12624-12639 pubmed
Lee M, Nam T, Jung S, Gwak Y, Leem J. Modulation of Spinal GABAergic Inhibition and Mechanical Hypersensitivity following Chronic Compression of Dorsal Root Ganglion in the Rat. Neural Plast. 2015;2015:924728 pubmed publisher
Bragina L, Bonifacino T, Bassi S, Milanese M, Bonanno G, Conti F. Differential expression of metabotropic glutamate and GABA receptors at neocortical glutamatergic and GABAergic axon terminals. Front Cell Neurosci. 2015;9:345 pubmed publisher
Dobson K, Jackson C, Balakrishnan S, Bellamy T. Caffeine Modulates Vesicle Release and Recovery at Cerebellar Parallel Fibre Terminals, Independently of Calcium and Cyclic AMP Signalling. PLoS ONE. 2015;10:e0125974 pubmed publisher
Goforth P, Leinninger G, Patterson C, Satin L, Myers M. Leptin acts via lateral hypothalamic area neurotensin neurons to inhibit orexin neurons by multiple GABA-independent mechanisms. J Neurosci. 2014;34:11405-15 pubmed publisher
Mans R, Warmus B, Smith C, McMahon L. An acetylcholinesterase inhibitor, eserine, induces long-term depression at CA3-CA1 synapses in the hippocampus of adult rats. J Neurophysiol. 2014;112:2388-97 pubmed publisher
Yang S, Chung P, Ho C, Kuo C, Hung M, Huang Y, et al. Propofol inhibits superoxide production, elastase release, and chemotaxis in formyl peptide-activated human neutrophils by blocking formyl peptide receptor 1. J Immunol. 2013;190:6511-9 pubmed publisher
Venkataraman Y, Bartlett E. Postnatal development of synaptic properties of the GABAergic projection from the inferior colliculus to the auditory thalamus. J Neurophysiol. 2013;109:2866-82 pubmed publisher
Song I, Volynski K, Brenner T, Ushkaryov Y, Walker M, Semyanov A. Different transporter systems regulate extracellular GABA from vesicular and non-vesicular sources. Front Cell Neurosci. 2013;7:23 pubmed publisher
Marrocco J, Mairesse J, Ngomba R, Silletti V, Van Camp G, Bouwalerh H, et al. Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. J Neurosci. 2012;32:17143-54 pubmed publisher
Chacón M, Navarro A, Cuesto G, del Pino I, Scott R, Morales M, et al. Focal adhesion kinase regulates actin nucleation and neuronal filopodia formation during axonal growth. Development. 2012;139:3200-10 pubmed publisher
Xiao Y, Huang X, Van Wert S, Barreto E, Wu J, Gluckman B, et al. The role of inhibition in oscillatory wave dynamics in the cortex. Eur J Neurosci. 2012;36:2201-12 pubmed publisher
Caiati M, Sivakumaran S, Lanore F, Mulle C, Richard E, Verrier D, et al. Developmental regulation of CB1-mediated spike-time dependent depression at immature mossy fiber-CA3 synapses. Sci Rep. 2012;2:285 pubmed publisher
Parker J, WANAT M, Soden M, Ahmad K, Zweifel L, Bamford N, et al. Attenuating GABA(A) receptor signaling in dopamine neurons selectively enhances reward learning and alters risk preference in mice. J Neurosci. 2011;31:17103-12 pubmed publisher
Li C, Dabrowska J, Hazra R, Rainnie D. Synergistic activation of dopamine D1 and TrkB receptors mediate gain control of synaptic plasticity in the basolateral amygdala. PLoS ONE. 2011;6:e26065 pubmed publisher
Lam D, Leinninger G, Louis G, Garfield A, Marston O, Leshan R, et al. Leptin does not directly affect CNS serotonin neurons to influence appetite. Cell Metab. 2011;13:584-91 pubmed publisher
Adedoyin M, Vicini S, Neale J. Endogenous N-acetylaspartylglutamate (NAAG) inhibits synaptic plasticity/transmission in the amygdala in a mouse inflammatory pain model. Mol Pain. 2010;6:60 pubmed publisher
Wu P, Coultrap S, Browning M, Proctor W. Correlated changes in NMDA receptor phosphorylation, functional activity, and sedation by chronic ethanol consumption. J Neurochem. 2010;115:1112-22 pubmed publisher
Moore S, Cooper D, Spruston N. Plasticity of burst firing induced by synergistic activation of metabotropic glutamate and acetylcholine receptors. Neuron. 2009;61:287-300 pubmed publisher
Kelm M, Criswell H, Breese G. The role of protein kinase A in the ethanol-induced increase in spontaneous GABA release onto cerebellar Purkinje neurons. J Neurophysiol. 2008;100:3417-28 pubmed publisher
Jensen T, Filoteo A, Knopfel T, Empson R. Presynaptic plasma membrane Ca2+ ATPase isoform 2a regulates excitatory synaptic transmission in rat hippocampal CA3. J Physiol. 2007;579:85-99 pubmed
product information
master code :
1246
SKU :
1246/10
product name :
CGP 52432
unit size :
10 mg (also 50 mg)
description :
Potent and selective GABAB antagonist
target :
GABA-B Receptor Antagonists
category :
Small Molecules
purity :
98%
observed molecular weight :
384.24
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
CGP 52432 is a potent, selective GABAB receptor antagonist (IC50 = 85 nM).
top caption :
Potent and selective GABAB antagonist
extended description :
Potent and selective GABAB antagonist
chemical name text :
3-[[(3,4-Dichlorophenyl)methyl]amino]propyl] diethoxymethyl)phosphinic acid
formula :
C15H24Cl2NO4P
formula text :
C15H24Cl2NO4P
cas num :
139667-74-6
USD :
296 USD
product details :
Potent and selective GABAB antagonist
storage :
Store at +4░C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK