product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
1245/10
catalog :
1245/10
quantity :
10 mg (also 50 mg)
price :
261 USD
more info or order :
citations: 11
Reference
Zhao J, Li A, Rajsombath M, Dang Y, Selkoe D, Li S. Soluble A? Oligomers Impair Dipolar Heterodendritic Plasticity by Activation of mGluR in the Hippocampal CA1 Region. iScience. 2018;6:138-150 pubmed publisher
Huang S, Green M, de Carvalho A, Mumau M, Chen Y, D Souza S, et al. The in vitro generation of lung and airway progenitor cells from human pluripotent stem cells. Nat Protoc. 2015;10:413-25 pubmed publisher
Aubdool A, Graepel R, Kodji X, Alawi K, Bodkin J, Srivastava S, et al. TRPA1 is essential for the vascular response to environmental cold exposure. Nat Commun. 2014;5:5732 pubmed publisher
Xia Y, Zhao Y, Yang M, Zeng S, Shu Y. Regulation of action potential waveforms by axonal GABAA receptors in cortical pyramidal neurons. PLoS ONE. 2014;9:e100968 pubmed publisher
Vashchinkina E, Manner A, Vekovischeva O, den Hollander B, Uusi Oukari M, Aitta Aho T, et al. Neurosteroid Agonist at GABAA receptor induces persistent neuroplasticity in VTA dopamine neurons. Neuropsychopharmacology. 2014;39:727-37 pubmed publisher
Gantz S, Bunzow J, Williams J. Spontaneous inhibitory synaptic currents mediated by a G protein-coupled receptor. Neuron. 2013;78:807-12 pubmed publisher
Gantz S, Ford C, Neve K, Williams J. Loss of Mecp2 in substantia nigra dopamine neurons compromises the nigrostriatal pathway. J Neurosci. 2011;31:12629-37 pubmed publisher
Lecrux C, Toussay X, Kocharyan A, Fernandes P, Neupane S, Levesque M, et al. Pyramidal neurons are "neurogenic hubs" in the neurovascular coupling response to whisker stimulation. J Neurosci. 2011;31:9836-47 pubmed publisher
Gaier E, Rodriguiz R, Ma X, Sivaramakrishnan S, Bousquet Moore D, Wetsel W, et al. Haploinsufficiency in peptidylglycine alpha-amidating monooxygenase leads to altered synaptic transmission in the amygdala and impaired emotional responses. J Neurosci. 2010;30:13656-69 pubmed publisher
Milenkovic I, Witte M, Turecek R, Heinrich M, Reinert T, Rubsamen R. Development of chloride-mediated inhibition in neurons of the anteroventral cochlear nucleus of gerbil (Meriones unguiculatus). J Neurophysiol. 2007;98:1634-44 pubmed
Wood M, Murkitt K, Rice S, Testa T, Punia P, Stammers M, et al. The human GABA(B1b) and GABA(B2) heterodimeric recombinant receptor shows low sensitivity to phaclofen and saclofen. Br J Pharmacol. 2000;131:1050-4 pubmed
product information
master code :
1245
SKU :
1245/10
product name :
CGP 35348
unit size :
10 mg (also 50 mg)
description :
Selective GABAB antagonist; brain penetrant
target :
GABA-B Receptor Antagonists
category :
Small Molecules
observed molecular weight :
225.22
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
CGP 35348 is a selective, brain penetrant GABAB receptor antagonist (IC50 = 34 u M as measured in rat cortical membranes). Has higher affinity for postsynaptic versus presynaptic receptors.
top caption :
Selective GABAB antagonist; brain penetrant
extended description :
Selective GABAB antagonist; brain penetrant
chemical name text :
(3-Aminopropyl)(diethoxymethyl)phosphinic acid
formula :
C8H20NO4P
formula text :
C8H20NO4P
cas num :
123690-79-9
USD :
261 USD
product details :
Selective GABAB antagonist; brain penetrant
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK