1240/10 | Tocris Bioscience 1240/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

1240/10

catalog :

1240/10

quantity :

10 mg (also 50 mg)

price :

237 USD

more info or order :

Tocris Bioscience product webpage

citations: 11

Reference
Su L, Bryan N, Battista S, Freitas J, Garabedian A, D Alessio F, et al. Identification of HMGA2 inhibitors by AlphaScreen-based ultra-high-throughput screening assays. Sci Rep. 2020;10:18850 pubmed publisher
Gao J, Xin W, Huang J, Ji B, Gao S, Chen L, et al. Research articleHemolysis in human erythrocytes by Clostridium perfringens epsilon toxin requires activation of P2 receptors. Virulence. 2018;9:1601-1614 pubmed publisher
Nishimura Y, McLaughlin N, Pan J, Goldstein S, Hafenstein S, Shimizu H, et al. The Suramin Derivative NF449 Interacts with the 5-fold Vertex of the Enterovirus A71 Capsid to Prevent Virus Attachment to PSGL-1 and Heparan Sulfate. PLoS Pathog. 2015;11:e1005184 pubmed publisher
Ledderose C, Bao Y, Ledderose S, Woehrle T, Heinisch M, Yip L, et al. Mitochondrial Dysfunction, Depleted Purinergic Signaling, and Defective T Cell Vigilance and Immune Defense. J Infect Dis. 2016;213:456-64 pubmed publisher
Ren P, Zou G, Bailly B, Xu S, Zeng M, Chen X, et al. The approved pediatric drug suramin identified as a clinical candidate for the treatment of EV71 infection-suramin inhibits EV71 infection in vitro and in vivo. Emerg Microbes Infect. 2014;3:e62 pubmed publisher
Beckham T, Cheng J, Lu P, Shao Y, Troyer D, Lance R, et al. Acid ceramidase induces sphingosine kinase 1/S1P receptor 2-mediated activation of oncogenic Akt signaling. Oncogenesis. 2013;2:e49 pubmed publisher
Manohar M, Hirsh M, Chen Y, Woehrle T, Karande A, Junger W. ATP release and autocrine signaling through P2X4 receptors regulate ?? T cell activation. J Leukoc Biol. 2012;92:787-94 pubmed publisher
Fritsche G, Nairz M, Libby S, Fang F, Weiss G. Slc11a1 (Nramp1) impairs growth of Salmonella enterica serovar typhimurium in macrophages via stimulation of lipocalin-2 expression. J Leukoc Biol. 2012;92:353-9 pubmed publisher
Donnelly Roberts D, Namovic M, Han P, Jarvis M. Mammalian P2X7 receptor pharmacology: comparison of recombinant mouse, rat and human P2X7 receptors. Br J Pharmacol. 2009;157:1203-14 pubmed publisher
Gallego D, Gil V, Aleu J, Aulí M, Clave P, Jiménez M. Purinergic and nitrergic junction potential in the human colon. Am J Physiol Gastrointest Liver Physiol. 2008;295:G522-33 pubmed publisher
Labrakakis C, Tong C, Weissman T, Torsney C, Macdermott A. Localization and function of ATP and GABAA receptors expressed by nociceptors and other postnatal sensory neurons in rat. J Physiol. 2003;549:131-42 pubmed

product information

master code :

1240

SKU :

1240/10

product name :

NF 023

unit size :

10 mg (also 50 mg)

description :

Selective and competitive P2X1 antagonist

target :

P2X Receptor Antagonists

category :

Small Molecules

observed molecular weight :

1162.86

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

NF 023 is an a subtype-selective, competitive and reversible P2X1 receptor antagonist. Displays IC50 values of 0.21, 28.9, 50 and 100 u M for human P2X1, P2X3, P2X2, and P2X4-mediated responses respectively. Selective over adrenoceptors, histamine and P2Y receptors. Also selectively inhibits the -subunit of Go/i (EC50 ~300 nM). Also inhibits DNA-binding activity of HMGA2 (IC50 = 10.63 M).

top caption :

Selective and competitive P2X1 antagonist

extended description :

Selective and competitive P2X1 antagonist

chemical name text :

8,8 -[carbonylbis(imino-3,1-phenylenecarbonylimino)]bis-1,3,5-naphthalene-trisulphonic acid, hexasodium salt

formula :

C35H20N4Na6O21S6

formula text :

C35H20N4Na6O21S6

cas num :

104869-31-0

USD :

237 USD

product details :

Selective and competitive P2X1 antagonist

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage