Brefeldin A | Tocris Bioscience 1231 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Brefeldin A

catalog :

1231

quantity :

5 mg

price :

151 USD

more info or order :

Tocris Bioscience product webpage

citations: 10

Reference
Shemorry A, Harnoss J, Guttman O, Marsters S, Komuves L, Lawrence D, et al. Caspase-mediated cleavage of IRE1 controls apoptotic cell commitment during endoplasmic reticulum stress. elife. 2019;8: pubmed publisher
Fauster A, Rebsamen M, Willmann K, César Razquin A, Girardi E, Bigenzahn J, et al. Systematic genetic mapping of necroptosis identifies SLC39A7 as modulator of death receptor trafficking. Cell Death Differ. 2019;26:1138-1155 pubmed publisher
van Nieuwenhuijze A, Burton O, Lemaitre P, Denton A, Cascalho A, Goodchild R, et al. Mice Deficient in Nucleoporin Nup210 Develop Peripheral T Cell Alterations. Front Immunol. 2018;9:2234 pubmed publisher
Hossain M, Barua D, Arabkari V, Islam N, Gupta A, Gupta S. Hyperactivation of nuclear receptor coactivators induces PERK-dependent cell death. Oncotarget. 2018;9:11707-11721 pubmed publisher
Krokowski D, Guan B, Wu J, Zheng Y, Pattabiraman P, Jobava R, et al. GADD34 Function in Protein Trafficking Promotes Adaptation to Hyperosmotic Stress in Human Corneal Cells. Cell Rep. 2017;21:2895-2910 pubmed publisher
Bowen A, Bourke A, Hiester B, Hanus C, Kennedy M. Golgi-independent secretory trafficking through recycling endosomes in neuronal dendrites and spines. elife. 2017;6: pubmed publisher
Saba T, Chung Y, Hong J, Sajjan U, Bentley J, Hershenson M. Rhinovirus-induced macrophage cytokine expression does not require endocytosis or replication. Am J Respir Cell Mol Biol. 2014;50:974-84 pubmed publisher
Halff A, Gomez Varela D, John D, Berg D. A novel mechanism for nicotinic potentiation of glutamatergic synapses. J Neurosci. 2014;34:2051-64 pubmed publisher
Grassin Delyle S, Abrial C, Fayad Kobeissi S, Brollo M, Faisy C, Alvarez J, et al. The expression and relaxant effect of bitter taste receptors in human bronchi. Respir Res. 2013;14:134 pubmed publisher
Jing H, Na T, Zhang W, Wu G, Liu C, Peng J. Concerted actions of NHERF2 and WNK4 in regulating TRPV5. Biochem Biophys Res Commun. 2011;404:979-84 pubmed publisher

product information

brand :

Tocris

master code :

1231

SKU :

1231/5

product name :

Brefeldin A

description :

Disrupts protein translocation to Golgi

target :

Translocation, Exo/Endocytosis Products

category :

Small Molecules

unit size :

5 mg

purity :

98%

observed molecular weight :

280.36

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Reversible inhibitor of protein translocation from the endoplasmic reticulum (ER) to the Golgi apparatus. Blocks binding of ADP-ribosylation factor (ARF1) to the Golgi apparatus and inhibits GDP-GTP exchange. Can be used to induce autophagy in mammalian cells. Also enhances CRISPR-mediated homology-directed repair (HDR) efficiency ~2-fold when applied at 100 nM, in human induced pluripotent stem cells (iPSCs). Antifungal.

catalog number base :

1231

product keywords :

Disrupts protein translocation Golgi ADP-ribosylation factor BrefeldinA HDR homology-directed repair CRISPR cas9 ARF1 Translocation, Exocytosis & Endocytosis Autophagy CRISPR Reagents Translocation 1231,

extended description :

Disrupts protein translocation to Golgi

chemical name text :

1,6,7,8,9,11a ,12,13,14,14 a-Decahydro-1 ,13 -dihydroxy-6 -methyl-4H-cyclopent(f)oxacyclotridecin-4-one

formula :

C 16 H 24 O 4

formula text :

C16H24O4

cas num :

20350-15-6

2020 USD :

145

2021 USD :

151 USD

storage :

Desiccate at -20°C

more info or order :

Tocris Bioscience product webpage