1231/5 | Tocris Bioscience 1231/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

1231/5

catalog :

1231/5

quantity :

5 mg

price :

195 USD

more info or order :

Tocris Bioscience product webpage

citations: 13

Reference
Shemorry A, Harnoss J, Guttman O, Marsters S, Komuves L, Lawrence D, et al. Caspase-mediated cleavage of IRE1 controls apoptotic cell commitment during endoplasmic reticulum stress. elife. 2019;8: pubmed publisher
van Nieuwenhuijze A, Burton O, Lemaitre P, Denton A, Cascalho A, Goodchild R, et al. Mice Deficient in Nucleoporin Nup210 Develop Peripheral T Cell Alterations. Front Immunol. 2018;9:2234 pubmed publisher
Fauster A, Rebsamen M, Willmann K, César Razquin A, Girardi E, Bigenzahn J, et al. Systematic genetic mapping of necroptosis identifies SLC39A7 as modulator of death receptor trafficking. Cell Death Differ. 2019;26:1138-1155 pubmed publisher
Hossain M, Barua D, Arabkari V, Islam N, Gupta A, Gupta S. Hyperactivation of nuclear receptor coactivators induces PERK-dependent cell death. Oncotarget. 2018;9:11707-11721 pubmed publisher
Krokowski D, Guan B, Wu J, Zheng Y, Pattabiraman P, Jobava R, et al. GADD34 Function in Protein Trafficking Promotes Adaptation to Hyperosmotic Stress in Human Corneal Cells. Cell Rep. 2017;21:2895-2910 pubmed publisher
Bowen A, Bourke A, Hiester B, Hanus C, Kennedy M. Golgi-independent secretory trafficking through recycling endosomes in neuronal dendrites and spines. elife. 2017;6: pubmed publisher
Saba T, Chung Y, Hong J, Sajjan U, Bentley J, Hershenson M. Rhinovirus-induced macrophage cytokine expression does not require endocytosis or replication. Am J Respir Cell Mol Biol. 2014;50:974-84 pubmed publisher
Halff A, Gomez Varela D, John D, Berg D. A novel mechanism for nicotinic potentiation of glutamatergic synapses. J Neurosci. 2014;34:2051-64 pubmed publisher
Crotta S, Davidson S, Mahlakõiv T, Desmet C, Buckwalter M, Albert M, et al. Type I and type III interferons drive redundant amplification loops to induce a transcriptional signature in influenza-infected airway epithelia. PLoS Pathog. 2013;9:e1003773 pubmed publisher
Grassin Delyle S, Abrial C, Fayad Kobeissi S, Brollo M, Faisy C, Alvarez J, et al. The expression and relaxant effect of bitter taste receptors in human bronchi. Respir Res. 2013;14:134 pubmed publisher
Chuang J, Kjalarsdottir L, Sakata I, Walker A, Kuperman A, Osborne Lawrence S, et al. Role of calcium and EPAC in norepinephrine-induced ghrelin secretion. Endocrinology. 2014;155:98-107 pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Jing H, Na T, Zhang W, Wu G, Liu C, Peng J. Concerted actions of NHERF2 and WNK4 in regulating TRPV5. Biochem Biophys Res Commun. 2011;404:979-84 pubmed publisher

image

image 1 :

Cat.No. 1231 - Brefeldin A C16H24O4 CAS No. 20350-15-6

product information

master code :

1231

SKU :

1231/5

product name :

Brefeldin A

unit size :

5 mg

description :

Disrupts protein translocation to Golgi

target :

Translocation, Exo/Endocytosis Products

category :

Small Molecules

purity :

98%

observed molecular weight :

280.36

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Brefeldin A is a reversible inhibitor of protein translocation from the endoplasmic reticulum (ER) to the Golgi apparatus. Blocks binding of ADP-ribosylation factor (ARF1) to the Golgi apparatus and inhibits GDP-GTP exchange, leading to activation of ER stress signaling pathways. Can be used to induce autophagy in mammalian cells. Also enhances CRISPR-mediated homology-directed repair (HDR) efficiency ~2-fold when applied at 100 nM, in human induced pluripotent stem cells (iPSCs). Antifungal.

top caption :

Disrupts protein translocation to Golgi

extended description :

Disrupts protein translocation to Golgi

chemical name text :

1,6,7,8,9,11a ,12,13,14,14a -Decahydro-1 ,13 -dihydroxy-6 -methyl-4H-cyclopent[f]oxacyclotridecin-4-one

formula :

C16H24O4

formula text :

C16H24O4

cas num :

20350-15-6

USD :

195 USD

product details :

Disrupts protein translocation to Golgi

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage