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company name :
Tocris Bioscience
product type :
chemical
product name :
1229/10
catalog :
1229/10
quantity :
10 mg
price :
212 USD
more info or order :
citations: 23
Reference
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Thomson S, Seo S, Barnes S, Louros S, Muscas M, Dando O, et al. Cell-Type-Specific Translation Profiling Reveals a Novel Strategy for Treating Fragile X Syndrome. Neuron. 2017;95:550-563.e5 pubmed publisher
Connor R, Jones L, Qiu X, Thakar J, Maggirwar S. Frontline Science: c-Myc regulates P-selectin glycoprotein ligand-1 expression in monocytes during HIV-1 infection. J Leukoc Biol. 2017;102:953-964 pubmed publisher
Ríos Colón L, Cajigas Du Ross C, Basu A, Elix C, Alicea Polanco I, Sanchez T, et al. Targeting the stress oncoprotein LEDGF/p75 to sensitize chemoresistant prostate cancer cells to taxanes. Oncotarget. 2017;8:24915-24931 pubmed publisher
Visavadiya N, Keasey M, Razskazovskiy V, Banerjee K, Jia C, Lovins C, et al. Integrin-FAK signaling rapidly and potently promotes mitochondrial function through STAT3. Cell Commun Signal. 2016;14:32 pubmed
Di S, Itoga C, Fisher M, Solomonow J, Roltsch E, Gilpin N, et al. Acute Stress Suppresses Synaptic Inhibition and Increases Anxiety via Endocannabinoid Release in the Basolateral Amygdala. J Neurosci. 2016;36:8461-70 pubmed publisher
Liu Y, Zhang L, Wang C, Roy S, Shen J. Purinergic P2Y2 Receptor Control of Tissue Factor Transcription in Human Coronary Artery Endothelial Cells: NEW AP-1 TRANSCRIPTION FACTOR SITE AND NEGATIVE REGULATOR. J Biol Chem. 2016;291:1553-63 pubmed publisher
Podszywalow Bartnicka P, Wolczyk M, Kusio Kobialka M, Wolanin K, Skowronek K, Nieborowska Skorska M, et al. Downregulation of BRCA1 protein in BCR-ABL1 leukemia cells depends on stress-triggered TIAR-mediated suppression of translation. Cell Cycle. 2014;13:3727-41 pubmed publisher
Gutierrez E, Richardson D, Jansson P. The anticancer agent di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) overcomes prosurvival autophagy by two mechanisms: persistent induction of autophagosome synthesis and impairment of lysosomal integrity. J Biol Chem. 2014;289:33568-89 pubmed publisher
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product information
master code :
1229
SKU :
1229/10
product name :
Actinomycin D
unit size :
10 mg
description :
Inhibits RNA polymerase
target :
RNA/DNA Polymerase Inhibitors
category :
Small Molecules
purity :
95%
observed molecular weight :
1255.43
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Actinomycin D is an anti-neoplastic antibiotic. Inhibits RNA polymerase and is a potent inducer of apoptosis.
top caption :
Inhibits RNA polymerase
extended description :
Inhibits RNA polymerase
chemical name text :
2-Amino-(N,N)-1-bis(hexadecahydro-6,13-diisopropyl-2,5,9-trimethyl-1,4,7,11,14-pentaoxo-1H-pyrrolo[2,1]-[1,4,7,10,13] oxatetraazacyclohexadecin-10-yl)-4,6-dimethyl-3-oxo-3H-phenoxazine-1,9-dicarboxamide
formula :
C62H86N12O16
formula text :
C62H86N12O16
cas num :
50-76-0
USD :
212 USD
product details :
Inhibits RNA polymerase
storage :
Store at -20░C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK