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company name :
Tocris Bioscience
product type :
chemical
product name :
1224/10
catalog :
1224/10
quantity :
10 mg (also 50 mg)
price :
107 USD
more info or order :
citations: 53
Reference
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Hutchins B, Klenke U, Wray S. Calcium release-dependent actin flow in the leading process mediates axophilic migration. J Neurosci. 2013;33:11361-71 pubmed publisher
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product information
master code :
1224
SKU :
1224/10
product name :
2-APB
unit size :
10 mg (also 50 mg)
description :
IP3 receptor antagonist. Also TRP channel modulator
target :
Inositol Lipid Antagonists
category :
Small Molecules
purity :
98%
observed molecular weight :
225.1
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
2-APB is a functional and membrane permeable D-myo-inositol 1,4,5-trisphosphate (IP3) receptor antagonist (IC50 = 42 M). Stimulates store-operated calcium (SOC) release at low concentrations ( 10 M) and inhibits it at higher concentrations (up to 50 M). Increases STIM-Orai channel conductance and limits ion selectivity. Modulator of TRP channels; blocks TRPC1, TRPC3, TRPC5, TRPC6, TRPV6, TRPM3, TRPM7, TRPM8 and TRPP2 and at higher concentrations stimulates TRPV1, TRPV2 and TRPV3. Also blocks specific gap channel subtypes.
top caption :
IP3 receptor antagonist. Also TRP channel modulator
extended description :
IP3 receptor antagonist. Also TRP channel modulator
chemical name text :
2-Aminoethoxydiphenylborane
formula :
C14H16BNO
formula text :
C14H16BNO
cas num :
524-95-8
USD :
107 USD
product details :
IP3 receptor antagonist. Also TRP channel modulator
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK