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company name :
Tocris Bioscience
product type :
chemical
product name :
1223/10
catalog :
1223/10
quantity :
10 mg (also 50 mg)
price :
289 USD
more info or order :
citations: 64
Reference
Falcucci R, Wertz R, Green J, Meucci O, Salvino J, Fontana A. Novel Positive Allosteric Modulators of Glutamate Transport Have Neuroprotective Properties in an in Vitro Excitotoxic Model. ACS Chem Neurosci. 2019;10:3437-3453 pubmed publisher
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Romanos J, Benke D, Saab A, Zeilhofer H, Santello M. Differences in glutamate uptake between cortical regions impact neuronal NMDA receptor activation. Commun Biol. 2019;2:127 pubmed publisher
Woo J, Han Y, Koh W, Won J, Park M, An H, et al. Pharmacological Dissection of Intrinsic Optical Signal Reveals a Functional Coupling between Synaptic Activity and Astrocytic Volume Transient. Exp Neurobiol. 2019;28:30-42 pubmed publisher
Zhang L, Kunkler P, Knopp K, Oxford G, Hurley J. Role of intraganglionic transmission in the trigeminovascular pathway. Mol Pain. 2019;15:1744806919836570 pubmed publisher
Vincent P, Cho S, Tertrais M, Bouleau Y, von Gersdorff H, Dulon D. Clustered Ca2+ Channels Are Blocked by Synaptic Vesicle Proton Release at Mammalian Auditory Ribbon Synapses. Cell Rep. 2018;25:3451-3464.e3 pubmed publisher
Pérez Mato M, Iglesias Rey R, Vieites Prado A, Dopico López A, Argibay B, Fernández Susavila H, et al. Blood glutamate EAAT2-cell grabbing therapy in cerebral ischemia. EBioMedicine. 2019;39:118-131 pubmed publisher
Piccirillo S, Castaldo P, Macrì M, Amoroso S, Magi S. Glutamate as a potential "survival factor" in an in vitro model of neuronal hypoxia/reoxygenation injury: leading role of the Na+/Ca2+ exchanger. Cell Death Dis. 2018;9:731 pubmed publisher
Rossi M, Rubbini G, Martini M, Canella R, Fesce R. Pre- and Postsynaptic Effects of Glutamate in the Frog Labyrinth. Neuroscience. 2018;385:198-214 pubmed publisher
Thalman C, Horta G, Qiao L, Endle H, Tegeder I, Cheng H, et al. Synaptic phospholipids as a new target for cortical hyperexcitability and E/I balance in psychiatric disorders. Mol Psychiatry. 2018;23:1699-1710 pubmed publisher
Tchernookova B, Heer C, Young M, Swygart D, Kaufman R, Gongwer M, et al. Activation of retinal glial (Müller) cells by extracellular ATP induces pronounced increases in extracellular H+ flux. PLoS ONE. 2018;13:e0190893 pubmed publisher
Kovermann P, Hessel M, Kortzak D, Jen J, Koch J, Fahlke C, et al. Impaired K+ binding to glial glutamate transporter EAAT1 in migraine. Sci Rep. 2017;7:13913 pubmed publisher
Lu H, Balmer T, Romero G, Trussell L. Slow AMPAR Synaptic Transmission Is Determined by Stargazin and Glutamate Transporters. Neuron. 2017;96:73-80.e4 pubmed publisher
Sloan S, Darmanis S, Huber N, Khan T, Birey F, Caneda C, et al. Human Astrocyte Maturation Captured in 3D Cerebral Cortical Spheroids Derived from Pluripotent Stem Cells. Neuron. 2017;95:779-790.e6 pubmed publisher
Brancaccio M, Patton A, Chesham J, Maywood E, Hastings M. Astrocytes Control Circadian Timekeeping in the Suprachiasmatic Nucleus via Glutamatergic Signaling. Neuron. 2017;93:1420-1435.e5 pubmed publisher
Agarwal A, Wu P, Hughes E, Fukaya M, Tischfield M, Langseth A, et al. Transient Opening of the Mitochondrial Permeability Transition Pore Induces Microdomain Calcium Transients in Astrocyte Processes. Neuron. 2017;93:587-605.e7 pubmed publisher
Romei C, Bonifacino T, Milanese M, Usai C, Raiteri L. Colocalization of neurotransmitter transporters on the plasma membrane of the same nerve terminal may reflect cotransmission. Brain Res Bull. 2016;127:100-110 pubmed publisher
Kuebler E, Tauskela J, Aylsworth A, Zhao X, Thivierge J. Burst predicting neurons survive an in vitro glutamate injury model of cerebral ischemia. Sci Rep. 2015;5:17718 pubmed publisher
Huang L, Zhao S, Lu W, Guan S, Zhu Y, Wang J. Acidosis-Induced Dysfunction of Cortical GABAergic Neurons through Astrocyte-Related Excitotoxicity. PLoS ONE. 2015;10:e0140324 pubmed publisher
Rosa J, Bos R, Sack G, Fortuny C, Agarwal A, Bergles D, et al. Neuron-glia signaling in developing retina mediated by neurotransmitter spillover. elife. 2015;4: pubmed publisher
Megill A, Tran T, Eldred K, Lee N, Wong P, HOE H, et al. Defective Age-Dependent Metaplasticity in a Mouse Model of Alzheimer's Disease. J Neurosci. 2015;35:11346-57 pubmed publisher
Falgairolle M, O Donovan M. Pharmacological Investigation of Fluoro-Gold Entry into Spinal Neurons. PLoS ONE. 2015;10:e0131430 pubmed publisher
Pedraz Cuesta E, Christensen S, Jensen A, Jensen N, Bunch L, Romer M, et al. The glutamate transport inhibitor DL-Threo-β-Benzyloxyaspartic acid (DL-TBOA) differentially affects SN38- and oxaliplatin-induced death of drug-resistant colorectal cancer cells. BMC Cancer. 2015;15:411 pubmed publisher
Petr G, Sun Y, Frederick N, Zhou Y, Dhamne S, Hameed M, et al. Conditional deletion of the glutamate transporter GLT-1 reveals that astrocytic GLT-1 protects against fatal epilepsy while neuronal GLT-1 contributes significantly to glutamate uptake into synaptosomes. J Neurosci. 2015;35:5187-201 pubmed publisher
Lin T, Lu C, Wu C, Huang S, Wang S. Palmitoylethanolamide inhibits glutamate release in rat cerebrocortical nerve terminals. Int J Mol Sci. 2015;16:5555-71 pubmed publisher
Griffin W, Ramachandra V, Knackstedt L, Becker H. Repeated cycles of chronic intermittent ethanol exposure increases basal glutamate in the nucleus accumbens of mice without affecting glutamate transport. Front Pharmacol. 2015;6:27 pubmed publisher
Vance K, Rogers R, Hermann G. PAR1-activated astrocytes in the nucleus of the solitary tract stimulate adjacent neurons via NMDA receptors. J Neurosci. 2015;35:776-85 pubmed publisher
Campbell S, Hablitz J, Olsen M. Functional changes in glutamate transporters and astrocyte biophysical properties in a rodent model of focal cortical dysplasia. Front Cell Neurosci. 2014;8:425 pubmed publisher
Armbruster M, Hampton D, Yang Y, Dulla C. Laser-scanning astrocyte mapping reveals increased glutamate-responsive domain size and disrupted maturation of glutamate uptake following neonatal cortical freeze-lesion. Front Cell Neurosci. 2014;8:277 pubmed publisher
Tse D, Chung I, Wu S. Pharmacological inhibitions of glutamate transporters EAAT1 and EAAT2 compromise glutamate transport in photoreceptor to ON-bipolar cell synapses. Vision Res. 2014;103:49-62 pubmed publisher
Chamberland S, Evstratova A, Tóth K. Interplay between synchronization of multivesicular release and recruitment of additional release sites support short-term facilitation at hippocampal mossy fiber to CA3 pyramidal cells synapses. J Neurosci. 2014;34:11032-47 pubmed publisher
Liang J, Chao D, Sandhu H, Yu Y, Zhang L, Balboni G, et al. ?-Opioid receptors up-regulate excitatory amino acid transporters in mouse astrocytes. Br J Pharmacol. 2014;171:5417-30 pubmed publisher
Tse D, Chung I, Wu S. Possible roles of glutamate transporter EAAT5 in mouse cone depolarizing bipolar cell light responses. Vision Res. 2014;103:63-74 pubmed publisher
Zhou H, Lin Z, Voges K, Ju C, Gao Z, Bosman L, et al. Cerebellar modules operate at different frequencies. elife. 2014;3:e02536 pubmed publisher
Cengiz P, Kintner D, Chanana V, Yuan H, Akture E, Kendigelen P, et al. Sustained Na+/H+ exchanger activation promotes gliotransmitter release from reactive hippocampal astrocytes following oxygen-glucose deprivation. PLoS ONE. 2014;9:e84294 pubmed publisher
McCall J, Kim T, Shin G, Huang X, Jung Y, Al Hasani R, et al. Fabrication and application of flexible, multimodal light-emitting devices for wireless optogenetics. Nat Protoc. 2013;8:2413-2428 pubmed publisher
Jeon J, Paik S, Chun M, Oh U, Kim I. Presynaptic Localization and Possible Function of Calcium-Activated Chloride Channel Anoctamin 1 in the Mammalian Retina. PLoS ONE. 2013;8:e67989 pubmed publisher
Tovar Y Romo L, Kolson D, Bandaru V, Drewes J, Graham D, Haughey N. Adenosine triphosphate released from HIV-infected macrophages regulates glutamatergic tone and dendritic spine density on neurons. J Neuroimmune Pharmacol. 2013;8:998-1009 pubmed publisher
Koeglsperger T, Li S, Brenneis C, Saulnier J, Mayo L, Carrier Y, et al. Impaired glutamate recycling and GluN2B-mediated neuronal calcium overload in mice lacking TGF-?1 in the CNS. Glia. 2013;61:985-1002 pubmed publisher
Georgieva E, Borbat P, Ginter C, Freed J, Boudker O. Conformational ensemble of the sodium-coupled aspartate transporter. Nat Struct Mol Biol. 2013;20:215-21 pubmed publisher
He S, Shao L, Wang Y, Bausch S. Synaptic and extrasynaptic plasticity in glutamatergic circuits involving dentate granule cells following chronic N-methyl-D-aspartate receptor inhibition. J Neurophysiol. 2013;109:1535-47 pubmed publisher
Okabe Y, Takahashi T, Mitsumasu C, Kosai K, Tanaka E, Matsuishi T. Alterations of gene expression and glutamate clearance in astrocytes derived from an MeCP2-null mouse model of Rett syndrome. PLoS ONE. 2012;7:e35354 pubmed publisher
Wang F, Smith N, Xu Q, Fujita T, Baba A, Matsuda T, et al. Astrocytes modulate neural network activity by Ca²+-dependent uptake of extracellular K+. Sci Signal. 2012;5:ra26 pubmed publisher
Ichinose T, Lukasiewicz P. The mode of retinal presynaptic inhibition switches with light intensity. J Neurosci. 2012;32:4360-71 pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Jarzylo L, Man H. Parasynaptic NMDA receptor signaling couples neuronal glutamate transporter function to AMPA receptor synaptic distribution and stability. J Neurosci. 2012;32:2552-63 pubmed publisher
Di Prisco S, Summa M, Chellakudam V, Rossi P, Pittaluga A. RANTES-mediated control of excitatory amino acid release in mouse spinal cord. J Neurochem. 2012;121:428-37 pubmed publisher
Miller B, Dorner J, Bunner K, Gaither T, Klein E, Barton S, et al. Up-regulation of GLT1 reverses the deficit in cortically evoked striatal ascorbate efflux in the R6/2 mouse model of Huntington's disease. J Neurochem. 2012;121:629-38 pubmed publisher
Yoshizumi M, Eisenach J, Hayashida K. Riluzole and gabapentinoids activate glutamate transporters to facilitate glutamate-induced glutamate release from cultured astrocytes. Eur J Pharmacol. 2012;677:87-92 pubmed publisher
Zou S, Fitting S, Hahn Y, Welch S, El Hage N, Hauser K, et al. Morphine potentiates neurodegenerative effects of HIV-1 Tat through actions at ?-opioid receptor-expressing glia. Brain. 2011;134:3616-31 pubmed publisher
Vandenberg R, Handford C, Campbell E, Ryan R, Yool A. Water and urea permeation pathways of the human excitatory amino acid transporter EAAT1. Biochem J. 2011;439:333-40 pubmed publisher
Maurer C, Schonthaler H, Mueller K, Neuhauss S. Distinct retinal deficits in a zebrafish pyruvate dehydrogenase-deficient mutant. J Neurosci. 2010;30:11962-72 pubmed publisher
De Biase L, Nishiyama A, Bergles D. Excitability and synaptic communication within the oligodendrocyte lineage. J Neurosci. 2010;30:3600-11 pubmed publisher
Mulholland P, Chandler L. Inhibition of glutamate transporters couples to Kv4.2 dephosphorylation through activation of extrasynaptic NMDA receptors. Neuroscience. 2010;165:130-7 pubmed publisher
Mohr C, Brady J, Rossi D. Young age and low temperature, but not female gender delay ATP loss and glutamate release, and protect Purkinje cells during simulated ischemia in cerebellar slices. Neuropharmacology. 2010;58:392-403 pubmed publisher
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Leveille F, El Gaamouch F, Gouix E, Lecocq M, Lobner D, Nicole O, et al. Neuronal viability is controlled by a functional relation between synaptic and extrasynaptic NMDA receptors. FASEB J. 2008;22:4258-71 pubmed publisher
Costa C, Belcastro V, Tozzi A, Di Filippo M, Tantucci M, Siliquini S, et al. Electrophysiology and pharmacology of striatal neuronal dysfunction induced by mitochondrial complex I inhibition. J Neurosci. 2008;28:8040-52 pubmed publisher
Stridh M, Tranberg M, Weber S, Blomstrand F, Sandberg M. Stimulated efflux of amino acids and glutathione from cultured hippocampal slices by omission of extracellular calcium: likely involvement of connexin hemichannels. J Biol Chem. 2008;283:10347-56 pubmed publisher
Baltan S, Besancon E, Mbow B, Ye Z, Hamner M, Ransom B. White matter vulnerability to ischemic injury increases with age because of enhanced excitotoxicity. J Neurosci. 2008;28:1479-89 pubmed publisher
Duguid I, Pankratov Y, Moss G, Smart T. Somatodendritic release of glutamate regulates synaptic inhibition in cerebellar Purkinje cells via autocrine mGluR1 activation. J Neurosci. 2007;27:12464-74 pubmed
Matsui J, Egana A, Sponholtz T, Adolph A, Dowling J. Effects of ethanol on photoreceptors and visual function in developing zebrafish. Invest Ophthalmol Vis Sci. 2006;47:4589-97 pubmed
Bender V, Bender K, Brasier D, Feldman D. Two coincidence detectors for spike timing-dependent plasticity in somatosensory cortex. J Neurosci. 2006;26:4166-77 pubmed
Yang C, Huang C, Hsu K. Behavioral stress enhances hippocampal CA1 long-term depression through the blockade of the glutamate uptake. J Neurosci. 2005;25:4288-93 pubmed
product information
master code :
1223
SKU :
1223/10
product name :
DL-TBOA
unit size :
10 mg (also 50 mg)
description :
Selective non-transportable inhibitor of EAATs
target :
Glutamate (EAAT) Transporter Inhibitors
category :
Small Molecules
purity :
98%
observed molecular weight :
239.23
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
DL-TBOA is a competitive, non-transportable blocker of excitatory amino acid transporters (IC50 values are 6 M, 6 M and 70 M, for EAAT2, EAAT3 and EAAT1, respectively). DL-TBOA also inhibits EAAT4 and EAAT5 (Ki values are 4.4 M and 3.2 M respectively). DL-TBOA displays high selectivity for EAATs over ionotropic and metabotropic glutamate receptors. In [3H]-d-Asp uptake assays in HEK293 cells expressing human EAAT2, EAAT1 and EAAT3, Ki values are 2.2, 2.9, and 9.3 M, respectively. In a FLIPR Membrane Potential (FMP) assay, Km values are 0.59, 1.8 and 2.8 M for human EAAT2, EAAT3 and EAAT1, respectively. DL-TBOA augments SN 38 (Cat. No. 2684) induced colorectal cancer cell death in drug-resistant cell lines. DL-TBOA enhances synaptic activity in the frog labyrinth.
top caption :
Selective non-transportable inhibitor of EAATs
extended description :
Selective non-transportable inhibitor of EAATs
chemical name text :
DL-threo- -Benzyloxyaspartic acid
formula :
C11H13NO5
formula text :
C11H13NO5
cas num :
205309-81-5
USD :
289 USD
product details :
Selective non-transportable inhibitor of EAATs
storage :
Desiccate at -20░C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK