1221/10 | Tocris Bioscience 1221/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

1221/10

catalog :

1221/10

quantity :

10 mg (also 50 mg)

price :

272 USD

more info or order :

Tocris Bioscience product webpage

citations: 8

Reference
Hirono M, Nagao S, Yanagawa Y, Konishi S. Monoaminergic modulation of GABAergic transmission onto cerebellar globular cells. Neuropharmacology. 2017;118:79-89 pubmed publisher
Cassilly C, Maddox M, Cherian P, Bowling J, Hamann M, Lee R, et al. SB-224289 Antagonizes the Antifungal Mechanism of the Marine Depsipeptide Papuamide A. PLoS ONE. 2016;11:e0154932 pubmed publisher
Baillie L, Ahn A, Mulligan S. Sumatriptan inhibition of N-type calcium channel mediated signaling in dural CGRP terminal fibres. Neuropharmacology. 2012;63:362-7 pubmed publisher
Morecroft I, White K, Caruso P, Nilsen M, Loughlin L, Alba R, et al. Gene therapy by targeted adenovirus-mediated knockdown of pulmonary endothelial Tph1 attenuates hypoxia-induced pulmonary hypertension. Mol Ther. 2012;20:1516-28 pubmed publisher
Murray K, Stephens M, Rank M, D Amico J, Gorassini M, Bennett D. Polysynaptic excitatory postsynaptic potentials that trigger spasms after spinal cord injury in rats are inhibited by 5-HT1B and 5-HT1F receptors. J Neurophysiol. 2011;106:925-43 pubmed publisher
Hampson L, Mackin P, Agius L. Stimulation of glycogen synthesis and inactivation of phosphorylase in hepatocytes by serotonergic mechanisms, and counter-regulation by atypical antipsychotic drugs. Diabetologia. 2007;50:1743-51 pubmed
Siddiqui E, Shabbir M, Mikhailidis D, Thompson C, Mumtaz F. The role of serotonin (5-hydroxytryptamine1A and 1B) receptors in prostate cancer cell proliferation. J Urol. 2006;176:1648-53 pubmed
Heisler L, Jobst E, Sutton G, Zhou L, Borok E, Thornton Jones Z, et al. Serotonin reciprocally regulates melanocortin neurons to modulate food intake. Neuron. 2006;51:239-49 pubmed

product information

master code :

1221

SKU :

1221/10

product name :

SB 224289 hydrochloride

unit size :

10 mg (also 50 mg)

description :

Selective 5-HT1B antagonist

target :

5-HT1B Receptor Antagonists

category :

Small Molecules

purity :

95%

observed molecular weight :

557.09

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

SB 224289 hydrochloride is a selective 5-HT1B receptor antagonist (pKi = 8.2). Displays 60-fold selectivity over 5-HT1D, 5-HT1A, 5-HT1E, 5-HT1F, 5-HT2A and 5-HT2C receptors in radioligand binding and functional assays. Centrally active following oral administration in vivo .

top caption :

Selective 5-HT1B antagonist

extended description :

Selective 5-HT1B antagonist

chemical name text :

1 -Methyl-5-[[2 -methyl-4 -(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl]-2,3,6,7-tetrahydrospiro[furo[2,3-f]indole-3,4 -piperidine hydrochloride

formula :

C32H32N4O3.HCl

formula text :

C32H32N4O3.HCl

cas num :

180084-26-8

USD :

272 USD

product details :

Selective 5-HT1B antagonist

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage