product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
1217/5
catalog :
1217/5
quantity :
5 mg
price :
271 USD
more info or order :
citations: 15
Reference
Liu G, Zhang W, Guo J, Kong F, Zhou S, Chen S, et al. Adenosine binds predominantly to adenosine receptor A1 subtype in astrocytes and mediates an immunosuppressive effect. Brain Res. 2018;1700:47-55 pubmed publisher
Kinoshita M, Hirayama Y, Fujishita K, Shibata K, Shinozaki Y, Shigetomi E, et al. Anti-Depressant Fluoxetine Reveals its Therapeutic Effect Via Astrocytes. EBioMedicine. 2018;32:72-83 pubmed publisher
Liang D, Woo J, Shao H, Born W, O Brien R, Kaplan H, et al. Ability of γδ T cells to modulate the Foxp3 T cell response is dependent on adenosine. PLoS ONE. 2018;13:e0197189 pubmed publisher
Torres A, Vargas Y, Uribe D, Jaramillo C, Gleisner A, Salazar Onfray F, et al. Adenosine A3 receptor elicits chemoresistance mediated by multiple resistance-associated protein-1 in human glioblastoma stem-like cells. Oncotarget. 2016;7:67373-67386 pubmed publisher
Stoddart L, Johnstone E, Wheal A, Goulding J, Robers M, Machleidt T, et al. Application of BRET to monitor ligand binding to GPCRs. Nat Methods. 2015;12:661-663 pubmed publisher
Liñán Rico A, Wunderlich J, Enneking J, Tso D, Grants I, Williams K, et al. Neuropharmacology of purinergic receptors in human submucous plexus: Involvement of P2X₁, P2X₂, P2X₃ channels, P2Y and A₃ metabotropic receptors in neurotransmission. Neuropharmacology. 2015;95:83-99 pubmed publisher
Corriden R, Kilpatrick L, Kellam B, Briddon S, Hill S. Kinetic analysis of antagonist-occupied adenosine-A3 receptors within membrane microdomains of individual cells provides evidence of receptor dimerization and allosterism. FASEB J. 2014;28:4211-22 pubmed publisher
Kozma E, Gizewski E, Tosh D, Squarcialupi L, Auchampach J, Jacobson K. Characterization by flow cytometry of fluorescent, selective agonist probes of the A(3) adenosine receptor. Biochem Pharmacol. 2013;85:1171-81 pubmed publisher
Stoddart L, Vernall A, Denman J, Briddon S, Kellam B, Hill S. Fragment screening at adenosine-A(3) receptors in living cells using a fluorescence-based binding assay. Chem Biol. 2012;19:1105-15 pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Long X, Mokelke E, Neeb Z, Alloosh M, Edwards J, Sturek M. Adenosine receptor regulation of coronary blood flow in Ossabaw miniature swine. J Pharmacol Exp Ther. 2010;335:781-7 pubmed publisher
Pugliese A, Coppi E, Spalluto G, Corradetti R, Pedata F. A3 adenosine receptor antagonists delay irreversible synaptic failure caused by oxygen and glucose deprivation in the rat CA1 hippocampus in vitro. Br J Pharmacol. 2006;147:524-32 pubmed
Germack R, Dickenson J. Characterization of ERK1/2 signalling pathways induced by adenosine receptor subtypes in newborn rat cardiomyocytes. Br J Pharmacol. 2004;141:329-39 pubmed
Wen L, Knowles A. Extracellular ATP and adenosine induce cell apoptosis of human hepatoma Li-7A cells via the A3 adenosine receptor. Br J Pharmacol. 2003;140:1009-18 pubmed
De Man J, Seerden T, De Winter B, Van Marck E, Herman A, Pelckmans P. Alteration of the purinergic modulation of enteric neurotransmission in the mouse ileum during chronic intestinal inflammation. Br J Pharmacol. 2003;139:172-84 pubmed
product information
master code :
1217
SKU :
1217/5
product name :
MRS 1220
unit size :
5 mg
description :
Highly potent and selective hA3 antagonist
target :
Adenosine A3 Receptor Antagonists
category :
Small Molecules
purity :
98%
observed molecular weight :
403.83
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
MRS 1220 is a potent and highly selective antagonist at the human A3 adenosine receptor (Ki values are 0.65, 305, and 52 nM at hA3, rA1 and rA2A respectively. Displays an IC50 value 1 u M for inhibition of binding to rat A3 receptors).
top caption :
Highly potent and selective hA3 antagonist
extended description :
Highly potent and selective hA3 antagonist
chemical name text :
N-[9-Chloro-2-(2-furanyl)[1,2,4]-triazolo[1,5-c]quinazolin-5-yl]benzene acetamide
formula :
C21H14ClN5O2
formula text :
C21H14ClN5O2
cas num :
183721-15-5
USD :
271 USD
product details :
Highly potent and selective hA3 antagonist
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK