product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
1217/5
catalog :
1217/5
quantity :
5 mg
price :
271 USD
more info or order :
citations: 15
Reference |
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Liñán Rico A, Wunderlich J, Enneking J, Tso D, Grants I, Williams K, et al. Neuropharmacology of purinergic receptors in human submucous plexus: Involvement of P2Xâ‚, P2Xâ‚‚, P2X₃ channels, P2Y and A₃ metabotropic receptors in neurotransmission. Neuropharmacology. 2015;95:83-99 pubmed publisher
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Pugliese A, Coppi E, Spalluto G, Corradetti R, Pedata F. A3 adenosine receptor antagonists delay irreversible synaptic failure caused by oxygen and glucose deprivation in the rat CA1 hippocampus in vitro. Br J Pharmacol. 2006;147:524-32 pubmed
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Germack R, Dickenson J. Characterization of ERK1/2 signalling pathways induced by adenosine receptor subtypes in newborn rat cardiomyocytes. Br J Pharmacol. 2004;141:329-39 pubmed
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Wen L, Knowles A. Extracellular ATP and adenosine induce cell apoptosis of human hepatoma Li-7A cells via the A3 adenosine receptor. Br J Pharmacol. 2003;140:1009-18 pubmed
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De Man J, Seerden T, De Winter B, Van Marck E, Herman A, Pelckmans P. Alteration of the purinergic modulation of enteric neurotransmission in the mouse ileum during chronic intestinal inflammation. Br J Pharmacol. 2003;139:172-84 pubmed
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product information
master code :
1217
SKU :
1217/5
product name :
MRS 1220
unit size :
5 mg
description :
Highly potent and selective hA3 antagonist
target :
Adenosine A3 Receptor Antagonists
category :
Small Molecules
purity :
98%
observed molecular weight :
403.83
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
MRS 1220 is a potent and highly selective antagonist at the human A3 adenosine receptor (Ki values are 0.65, 305, and 52 nM at hA3, rA1 and rA2A respectively. Displays an IC50 value 1 u M for inhibition of binding to rat A3 receptors).
top caption :
Highly potent and selective hA3 antagonist
extended description :
Highly potent and selective hA3 antagonist
chemical name text :
N-[9-Chloro-2-(2-furanyl)[1,2,4]-triazolo[1,5-c]quinazolin-5-yl]benzene acetamide
formula :
C21H14ClN5O2
formula text :
C21H14ClN5O2
cas num :
183721-15-5
USD :
271 USD
product details :
Highly potent and selective hA3 antagonist
storage :
Store at RT
more info or order :
company information

Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com800-343-7475
headquarters: UK
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