SIB 1757 | Tocris Bioscience 1215 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

SIB 1757

catalog :

1215

quantity :

10 mg (also 50 mg)

price :

86 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Zhao J, Li A, Rajsombath M, Dang Y, Selkoe D, Li S. Soluble A? Oligomers Impair Dipolar Heterodendritic Plasticity by Activation of mGluR in the Hippocampal CA1 Region. iScience. 2018;6:138-150 pubmed publisher
Koeglsperger T, Li S, Brenneis C, Saulnier J, Mayo L, Carrier Y, et al. Impaired glutamate recycling and GluN2B-mediated neuronal calcium overload in mice lacking TGF-?1 in the CNS. Glia. 2013;61:985-1002 pubmed publisher
El Kouhen O, Lehto S, Pan J, Chang R, Baker S, Zhong C, et al. Blockade of mGluR1 receptor results in analgesia and disruption of motor and cognitive performances: effects of A-841720, a novel non-competitive mGluR1 receptor antagonist. Br J Pharmacol. 2006;149:761-74 pubmed

product information

brand :

Tocris

master code :

1215

SKU :

1215/10

product name :

SIB 1757

description :

Highly selective mGlu5 antagonist

target :

Group I mGluR Antagonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

observed molecular weight :

213.24

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

A highly selective antagonist for the mGlu5 metabotropic glutamate receptor subtype; displays an IC50 value of 0.4 u M at hmGlu5 compared with 30 u M at hmGlu1b, hmGlu2, hmGlu4, hmGlu6, hmGlu7 and hmGlu8.

catalog number base :

1215

product keywords :

selective mGlu5 mGluR5 antagonist Group I Receptors Glutamate Metabotropic SIB1757 Glutamate (Metabotropic) Group I Receptors 1215,

extended description :

Highly selective mGlu5 antagonist

chemical name text :

6-Methyl-2-(phenylazo)-3-pyridinol

formula :

C 12 H 11 N 3 O

formula text :

C12H11N3O

cas num :

31993-01-8

2020 USD :

2021 USD :

86 USD

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage