SIB 1893 | Tocris Bioscience 1214 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

SIB 1893

catalog :

1214

quantity :

10 mg (also 50 mg)

price :

118 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Edri R, Yaffe Y, Ziller M, Mutukula N, Volkman R, David E, et al. Analysing human neural stem cell ontogeny by consecutive isolation of Notch active neural progenitors. Nat Commun. 2015;6:6500 pubmed publisher
Mathiesen J, Svendsen N, Brauner Osborne H, Thomsen C, Ramirez M. Positive allosteric modulation of the human metabotropic glutamate receptor 4 (hmGluR4) by SIB-1893 and MPEP. Br J Pharmacol. 2003;138:1026-30 pubmed

product information

brand :

Tocris

master code :

1214

SKU :

1214/10

product name :

SIB 1893

description :

mGlu5 antagonist; also positive allosteric modulator at mGlu4 receptors

target :

Group I mGluR Antagonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

observed molecular weight :

195.26

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

A highly selective non-competitive antagonist for the metabotropic glutamate mGlu5 receptor subtype; displays an IC50 value of 0.3 u M at hmGlu5, compared with 100 u M at hmGlu1b, hmGlu2, hmGlu6, hmGlu7 and hmGlu8. Centrally active upon systemic administration in vivo . Positive allosteric modulator at mGlu4 receptors.

catalog number base :

1214

product keywords :

Positive allosteric modulators mGlu4 mGluR4 mGlu5 mGluR5 antagonist positive Group III Receptors Glutamate Metabotropic I SIB1893 PAM Glutamate (Metabotropic) Group I Receptors Glutamate (Metabotropic) Group III Receptors 1214,

extended description :

mGlu5 antagonist; also positive allosteric modulator at mGlu4 receptors

chemical name text :

2-Methyl-6-(2-phenylethenyl)pyridine

formula :

C 14 H 13 N

formula text :

C14H13N

cas num :

6266-99-5

2020 USD :

131

2021 USD :

118 USD

storage :

Desiccate at +4°C

more info or order :

Tocris Bioscience product webpage