product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
1209/1
catalog :
1209/1
quantity :
1 mg (also 10 mg)
price :
132 USD
more info or order :
citations: 66
Reference
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Cao D, Bai G, Ji Y, Karpowicz J, Traub R. EXPRESS: Histone hyperacetylation modulates spinal type II metabotropic glutamate receptor alleviating stress-induced visceral hypersensitivity in female rats. Mol Pain. 2016;12: pubmed publisher
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Rosa J, Bos R, Sack G, Fortuny C, Agarwal A, Bergles D, et al. Neuron-glia signaling in developing retina mediated by neurotransmitter spillover. elife. 2015;4: pubmed publisher
Truini A, Piroso S, Pasquale E, Notartomaso S, Di Stefano G, Lattanzi R, et al. N-acetyl-cysteine, a drug that enhances the endogenous activation of group-II metabotropic glutamate receptors, inhibits nociceptive transmission in humans. Mol Pain. 2015;11:14 pubmed publisher
Dunn F. Photoreceptor ablation initiates the immediate loss of glutamate receptors in postsynaptic bipolar cells in retina. J Neurosci. 2015;35:2423-31 pubmed publisher
Choi C, Schoenfeld B, Weisz E, Bell A, Chambers D, Hinchey J, et al. PDE-4 inhibition rescues aberrant synaptic plasticity in Drosophila and mouse models of fragile X syndrome. J Neurosci. 2015;35:396-408 pubmed publisher
Case D, Alamilla J, Gillespie D. VGLUT3 does not synergize GABA/glycine release during functional refinement of an inhibitory auditory circuit. Front Neural Circuits. 2014;8:140 pubmed publisher
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Grimes W, Hoon M, Briggman K, WONG R, Rieke F. Cross-synaptic synchrony and transmission of signal and noise across the mouse retina. elife. 2014;3:e03892 pubmed publisher
Chen Y, Lin H, Ng M, Hsiao Y, Wang C, Gean P, et al. Activation of mGluR2/3 underlies the effects of N-acetylcystein on amygdala-associated autism-like phenotypes in a valproate-induced rat model of autism. Front Behav Neurosci. 2014;8:219 pubmed publisher
Carbonaro T, Eshleman A, Forster M, Cheng K, Rice K, Gatch M. The role of 5-HT2A, 5-HT 2C and mGlu2 receptors in the behavioral effects of tryptamine hallucinogens N,N-dimethyltryptamine and N,N-diisopropyltryptamine in rats and mice. Psychopharmacology (Berl). 2015;232:275-84 pubmed publisher
Gee C, Peterlik D, Neuhäuser C, Bouhelal R, Kaupmann K, Laue G, et al. Blocking metabotropic glutamate receptor subtype 7 (mGlu7) via the Venus flytrap domain (VFTD) inhibits amygdala plasticity, stress, and anxiety-related behavior. J Biol Chem. 2014;289:10975-87 pubmed publisher
Miyamoto Y, Ishikawa Y, Iegaki N, Sumi K, Fu K, Sato K, et al. Overexpression of Shati/Nat8l, an N-acetyltransferase, in the nucleus accumbens attenuates the response to methamphetamine via activation of group II mGluRs in mice. Int J Neuropsychopharmacol. 2014;17:1283-94 pubmed publisher
Wang M, Li Y, Snyder M, Wang H, Li F, Gao W. Group II metabotropic glutamate receptor agonist LY379268 regulates AMPA receptor trafficking in prefrontal cortical neurons. PLoS ONE. 2013;8:e61787 pubmed publisher
Trepanier C, Lei G, Xie Y, MacDonald J. Group II metabotropic glutamate receptors modify N-methyl-D-aspartate receptors via Src kinase. Sci Rep. 2013;3:926 pubmed publisher
Marrocco J, Mairesse J, Ngomba R, Silletti V, Van Camp G, Bouwalerh H, et al. Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. J Neurosci. 2012;32:17143-54 pubmed publisher
Hoshi H, Tian L, Massey S, Mills S. Properties of the ON bistratified ganglion cell in the rabbit retina. J Comp Neurol. 2013;521:1497-509 pubmed publisher
Mahler S, Hensley Simon M, Tahsili Fahadan P, Lalumiere R, Thomas C, Fallon R, et al. Modafinil attenuates reinstatement of cocaine seeking: role for cystine-glutamate exchange and metabotropic glutamate receptors. Addict Biol. 2014;19:49-60 pubmed publisher
Peachey N, Pearring J, Bojang P, Hirschtritt M, Sturgill Short G, Ray T, et al. Depolarizing bipolar cell dysfunction due to a Trpm1 point mutation. J Neurophysiol. 2012;108:2442-51 pubmed publisher
Lee C, Sherman S. Intrinsic modulators of auditory thalamocortical transmission. Hear Res. 2012;287:43-50 pubmed publisher
Sher A, DeVries S. A non-canonical pathway for mammalian blue-green color vision. Nat Neurosci. 2012;15:952-3 pubmed publisher
Hulme S, Jones O, Ireland D, Abraham W. Calcium-dependent but action potential-independent BCM-like metaplasticity in the hippocampus. J Neurosci. 2012;32:6785-94 pubmed publisher
Ren B, Gu X, Zheng Y, Liu C, Wang D, Sun Y, et al. Intrathecal injection of metabotropic glutamate receptor subtype 3 and 5 agonist/antagonist attenuates bone cancer pain by inhibition of spinal astrocyte activation in a mouse model. Anesthesiology. 2012;116:122-32 pubmed publisher
Taman A, Ribeiro P. Characterization of a truncated metabotropic glutamate receptor in a primitive metazoan, the parasitic flatworm Schistosoma mansoni. PLoS ONE. 2011;6:e27119 pubmed publisher
Johnson K, Niswender C, Conn P, Xiang Z. Activation of group II metabotropic glutamate receptors induces long-term depression of excitatory synaptic transmission in the substantia nigra pars reticulata. Neurosci Lett. 2011;504:102-106 pubmed publisher
Pearring J, Bojang P, Shen Y, Koike C, Furukawa T, Nawy S, et al. A role for nyctalopin, a small leucine-rich repeat protein, in localizing the TRP melastatin 1 channel to retinal depolarizing bipolar cell dendrites. J Neurosci. 2011;31:10060-6 pubmed publisher
Ster J, Mateos J, Grewe B, Coiret G, Corti C, Corsi M, et al. Enhancement of CA3 hippocampal network activity by activation of group II metabotropic glutamate receptors. Proc Natl Acad Sci U S A. 2011;108:9993-7 pubmed publisher
Jin I, Kandel E, Hawkins R. Whereas short-term facilitation is presynaptic, intermediate-term facilitation involves both presynaptic and postsynaptic protein kinases and protein synthesis. Learn Mem. 2011;18:96-102 pubmed publisher
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Adedoyin M, Vicini S, Neale J. Endogenous N-acetylaspartylglutamate (NAAG) inhibits synaptic plasticity/transmission in the amygdala in a mouse inflammatory pain model. Mol Pain. 2010;6:60 pubmed publisher
Fuortes M, Rico M, Merlin L. Distinctions between persistent and reversible group I mGluR-induced epileptiform burst prolongation. Epilepsia. 2010;51:1633-7 pubmed publisher
Kim S, Fraser P, Westaway D, St George Hyslop P, Ehrlich M, Gandy S. Group II metabotropic glutamate receptor stimulation triggers production and release of Alzheimer's amyloid(beta)42 from isolated intact nerve terminals. J Neurosci. 2010;30:3870-5 pubmed publisher
Chen H, Stoker A, Markou A. The glutamatergic compounds sarcosine and N-acetylcysteine ameliorate prepulse inhibition deficits in metabotropic glutamate 5 receptor knockout mice. Psychopharmacology (Berl). 2010;209:343-50 pubmed publisher
Citri A, Soler Llavina G, Bhattacharyya S, Malenka R. N-methyl-D-aspartate receptor- and metabotropic glutamate receptor-dependent long-term depression are differentially regulated by the ubiquitin-proteasome system. Eur J Neurosci. 2009;30:1443-50 pubmed publisher
Sekizawa S, Bechtold A, Tham R, Bonham A. A novel postsynaptic group II metabotropic glutamate receptor role in modulating baroreceptor signal transmission. J Neurosci. 2009;29:11807-16 pubmed publisher
Muto T, Tsuchiya D, Morikawa K, Jingami H. Site-specific unglycosylation to improve crystallization of the metabotropic glutamate receptor 3 extracellular domain. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009;65:236-41 pubmed publisher
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Sheffler D, Conn P. Allosteric potentiators of metabotropic glutamate receptor subtype 1a differentially modulate independent signaling pathways in baby hamster kidney cells. Neuropharmacology. 2008;55:419-27 pubmed publisher
Huang Y, Yasuda H, Sarihi A, Tsumoto T. Roles of endocannabinoids in heterosynaptic long-term depression of excitatory synaptic transmission in visual cortex of young mice. J Neurosci. 2008;28:7074-83 pubmed publisher
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Woo R, Li X, Tao Y, Carpenter Hyland E, Huang Y, Weber J, et al. Neuregulin-1 enhances depolarization-induced GABA release. Neuron. 2007;54:599-610 pubmed
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Galici R, Jones C, Hemstapat K, Nong Y, Echemendia N, Williams L, et al. Biphenyl-indanone A, a positive allosteric modulator of the metabotropic glutamate receptor subtype 2, has antipsychotic- and anxiolytic-like effects in mice. J Pharmacol Exp Ther. 2006;318:173-85 pubmed
Choi S, Chang J, Jiang B, Seol G, Min S, Han J, et al. Multiple receptors coupled to phospholipase C gate long-term depression in visual cortex. J Neurosci. 2005;25:11433-43 pubmed
Wang Q, Walsh D, Rowan M, Selkoe D, Anwyl R. Block of long-term potentiation by naturally secreted and synthetic amyloid beta-peptide in hippocampal slices is mediated via activation of the kinases c-Jun N-terminal kinase, cyclin-dependent kinase 5, and p38 mitogen-activated protein kinase as w. J Neurosci. 2004;24:3370-8 pubmed
Moore K, Nicoll R, Schmitz D. Adenosine gates synaptic plasticity at hippocampal mossy fiber synapses. Proc Natl Acad Sci U S A. 2003;100:14397-402 pubmed
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Fujino K, Oertel D. Bidirectional synaptic plasticity in the cerebellum-like mammalian dorsal cochlear nucleus. Proc Natl Acad Sci U S A. 2003;100:265-70 pubmed
product information
master code :
1209
SKU :
1209/1
product name :
LY 341495
unit size :
1 mg (also 10 mg)
description :
Highly potent and selective group II mGlu antagonist
target :
Group II mGluR Antagonists
category :
Small Molecules
purity :
98%
observed molecular weight :
353.37
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
LY 341495 is a highly potent and selective group II metabotropic glutamate receptor antagonist (Ki/IC50 values are 2.3, 1.3, 173, 990, 6800, 8200 and 22000 nM for human mGlu2, mGlu3, mGlu8, mGlu7a, mGlu1a, mGlu5a and mGlu4a receptors respectively). Readily brain penetrant and active in vivo . . Disodium salt (Cat. No. 4062) also available.
top caption :
Highly potent and selective group II mGlu antagonist
extended description :
Highly potent and selective group II mGlu antagonist
chemical name text :
(2S)-2-Amino-2-[(1S,2S)-2-carboxycycloprop-1-yl]-3-(xanth-9-yl) propanoic acid
formula :
C20H19NO5
formula text :
C20H19NO5
cas num :
201943-63-7
USD :
132 USD
product details :
Highly potent and selective group II mGlu antagonist
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK