1208/10 | Tocris Bioscience 1208/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

1208/10

catalog :

1208/10

quantity :

10 mg (also 50 mg)

price :

322 USD

more info or order :

Tocris Bioscience product webpage

citations: 9

Reference
Scholler P, Moreno Delgado D, Lecat Guillet N, Doumazane E, Monnier C, Charrier Savournin F, et al. HTS-compatible FRET-based conformational sensors clarify membrane receptor activation. Nat Chem Biol. 2017;13:372-380 pubmed publisher
McIlwrath S, Westlund K. Pharmacological attenuation of chronic alcoholic pancreatitis induced hypersensitivity in rats. World J Gastroenterol. 2015;21:836-53 pubmed publisher
De Pasquale R, Sherman S. A modulatory effect of the feedback from higher visual areas to V1 in the mouse. J Neurophysiol. 2013;109:2618-31 pubmed publisher
Lee C, Sherman S. Intrinsic modulators of auditory thalamocortical transmission. Hear Res. 2012;287:43-50 pubmed publisher
Ren B, Gu X, Zheng Y, Liu C, Wang D, Sun Y, et al. Intrathecal injection of metabotropic glutamate receptor subtype 3 and 5 agonist/antagonist attenuates bone cancer pain by inhibition of spinal astrocyte activation in a mouse model. Anesthesiology. 2012;116:122-32 pubmed publisher
Luheshi N, Giles J, Lopez Castejon G, Brough D. Sphingosine regulates the NLRP3-inflammasome and IL-1? release from macrophages. Eur J Immunol. 2012;42:716-25 pubmed publisher
Carlton S, Du J, Zhou S. Group II metabotropic glutamate receptor activation on peripheral nociceptors modulates TRPV1 function. Brain Res. 2009;1248:86-95 pubmed publisher
Proudfoot C, Garry E, Cottrell D, Rosie R, Anderson H, Robertson D, et al. Analgesia mediated by the TRPM8 cold receptor in chronic neuropathic pain. Curr Biol. 2006;16:1591-605 pubmed
Jiang Q, Yan Z, Feng J. Activation of group III metabotropic glutamate receptors attenuates rotenone toxicity on dopaminergic neurons through a microtubule-dependent mechanism. J Neurosci. 2006;26:4318-28 pubmed

product information

master code :

1208

SKU :

1208/10

product name :

(2R,4R)-APDC

unit size :

10 mg (also 50 mg)

description :

Highly selective group II agonist

target :

Group II mGluR Agonists

category :

Small Molecules

purity :

98%

observed molecular weight :

174.16

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

(2 R ,4 R )-APDC is a highly selective and relatively potent group II metabotropic glutamate receptor agonist. EC50 values are 0.4, 0.4, 100, 100, 300 and 300 u M for human mGlu2, mGlu3, mGlu1, mGlu5, mGlu4 and mGlu7 receptors respectively. Centrally active following systemic administration in vivo .

top caption :

Highly selective group II agonist

extended description :

Highly selective group II agonist

chemical name text :

(2R,4R)-4-Aminopyrrolidine-2,4-dicarboxylate

formula :

C6H10N2O4

formula text :

C6H10N2O4

cas num :

169209-63-6

USD :

322 USD

product details :

Highly selective group II agonist

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage