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company name :
Tocris Bioscience
product type :
chemical
product name :
1202/1
catalog :
1202/1
quantity :
1 mg (also 10 mg, 50 mg)
price :
155 USD
more info or order :
citations: 123
Reference
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Cai W, Rudolph J, Sengoku T, Andres D. Rit GTPase regulates a p38 MAPK-dependent neuronal survival pathway. Neurosci Lett. 2012;531:125-30 pubmed publisher
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Meotti F, Campos R, da Silva K, Paszcuk A, Costa R, Calixto J. Inflammatory muscle pain is dependent on the activation of kinin B? and B? receptors and intracellular kinase pathways. Br J Pharmacol. 2012;166:1127-39 pubmed publisher
Isfort K, Ebert F, Bornhorst J, Sargin S, Kardakaris R, Pasparakis M, et al. Real-time imaging reveals that P2Y2 and P2Y12 receptor agonists are not chemoattractants and macrophage chemotaxis to complement C5a is phosphatidylinositol 3-kinase (PI3K)- and p38 mitogen-activated protein kinase (MAPK)-independent. J Biol Chem. 2011;286:44776-87 pubmed publisher
Tsai C, Lin C, Wang Y. Carnosic acid induces the NAD(P)H: quinone oxidoreductase 1 expression in rat clone 9 cells through the p38/nuclear factor erythroid-2 related factor 2 pathway. J Nutr. 2011;141:2119-25 pubmed publisher
Kovac A, Erickson M, Banks W. Brain microvascular pericytes are immunoactive in culture: cytokine, chemokine, nitric oxide, and LRP-1 expression in response to lipopolysaccharide. J Neuroinflammation. 2011;8:139 pubmed publisher
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Sethi A, Jain A, Zode G, Wordinger R, Clark A. Role of TGFbeta/Smad signaling in gremlin induction of human trabecular meshwork extracellular matrix proteins. Invest Ophthalmol Vis Sci. 2011;52:5251-9 pubmed publisher
Kang J, Lee E, Park S, Chung I. MUC5AC expression through bidirectional communication of Notch and epidermal growth factor receptor pathways. J Immunol. 2011;187:222-9 pubmed publisher
Hecker L, Jagirdar R, Jin T, Thannickal V. Reversible differentiation of myofibroblasts by MyoD. Exp Cell Res. 2011;317:1914-21 pubmed publisher
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Yoo D, Kim C, Lee S, Kim H, Cho E, Park M, et al. Redox Factor-1 Inhibits Cyclooxygenase-2 Expression via Inhibiting of p38 MAPK in the A549 Cells. Korean J Physiol Pharmacol. 2010;14:139-44 pubmed publisher
Pera T, Gosens R, Lesterhuis A, Sami R, van der Toorn M, Zaagsma J, et al. Cigarette smoke and lipopolysaccharide induce a proliferative airway smooth muscle phenotype. Respir Res. 2010;11:48 pubmed publisher
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Yeligar S, Machida K, Tsukamoto H, Kalra V. Ethanol augments RANTES/CCL5 expression in rat liver sinusoidal endothelial cells and human endothelial cells via activation of NF-kappa B, HIF-1 alpha, and AP-1. J Immunol. 2009;183:5964-76 pubmed publisher
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Sutcliffe A, Clarke D, Bradbury D, Corbett L, Patel J, Knox A. Transcriptional regulation of monocyte chemotactic protein-1 release by endothelin-1 in human airway smooth muscle cells involves NF-kappaB and AP-1. Br J Pharmacol. 2009;157:436-50 pubmed publisher
Davis T, Kipling D. Assessing the role of stress signalling via p38 MAP kinase in the premature senescence of ataxia telangiectasia and Werner syndrome fibroblasts. Biogerontology. 2009;10:253-66 pubmed publisher
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Jung S, Yang W, Kim J, Kim H, Kim E, Yun H, et al. Reactive oxygen species stabilize hypoxia-inducible factor-1 alpha protein and stimulate transcriptional activity via AMP-activated protein kinase in DU145 human prostate cancer cells. Carcinogenesis. 2008;29:713-21 pubmed publisher
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Zhou J, Yu D, Cheng J, Shapiro D. Delayed and persistent ERK1/2 activation is required for 4-hydroxytamoxifen-induced cell death. Steroids. 2007;72:765-77 pubmed
Schlee M, Wehkamp J, Altenhoefer A, Oelschlaeger T, Stange E, Fellermann K. Induction of human beta-defensin 2 by the probiotic Escherichia coli Nissle 1917 is mediated through flagellin. Infect Immun. 2007;75:2399-407 pubmed
Katiyar S, Jiao X, Wagner E, Lisanti M, Pestell R. Somatic excision demonstrates that c-Jun induces cellular migration and invasion through induction of stem cell factor. Mol Cell Biol. 2007;27:1356-69 pubmed
Alao J, Stavropoulou A, Lam E, Coombes R. Role of glycogen synthase kinase 3 beta (GSK3beta) in mediating the cytotoxic effects of the histone deacetylase inhibitor trichostatin A (TSA) in MCF-7 breast cancer cells. Mol Cancer. 2006;5:40 pubmed
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Kauppinen T, Chan W, Suh S, Wiggins A, Huang E, Swanson R. Direct phosphorylation and regulation of poly(ADP-ribose) polymerase-1 by extracellular signal-regulated kinases 1/2. Proc Natl Acad Sci U S A. 2006;103:7136-41 pubmed
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Aiston S, Hampson L, Arden C, Iynedjian P, Agius L. The role of protein kinase B/Akt in insulin-induced inactivation of phosphorylase in rat hepatocytes. Diabetologia. 2006;49:174-82 pubmed
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master code :
1202
SKU :
1202/1
product name :
SB 203580
unit size :
1 mg (also 10 mg, 50 mg)
description :
Selective inhibitor of p38 MAPK
target :
p38 Inhibitors
category :
Small Molecules
purity :
98%
observed molecular weight :
377.44
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
SB 203580 is a selective inhibitor of p38 MAPK (IC50 values are 50 and 500 nM for SAPK2a/p38 and SAPK2b/p38 2 respectively). Displays 100-500-fold selectivity over LCK, GSK-3 and PKB . Shown to inhibit IL-2-induced T cell proliferation, cyclooxygenase-1 and -2, and thromboxane synthase. Enhances clonal growth of skin epithelial progenitor cells; stimulates neural stem cell (NSC) proliferation. SB 203580 is an essential component of medium for maintaining stem cells in naive pluripotent state and can be used to promote expansion of HSCs ex vivo . . Water-soluble Salt also available.
top caption :
Selective inhibitor of p38 MAPK
extended description :
Selective inhibitor of p38 MAPK
chemical name text :
4-[5-(4-Fluorophenyl)-2-[4-(methylsulfonyl)phenyl]-1H-imidazol-4-yl]pyridine
formula :
C21H16FN3OS
formula text :
C21H16FN3OS
cas num :
152121-47-6
USD :
155 USD
product details :
Selective inhibitor of p38 MAPK
storage :
Store at +4░C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK