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company name :
Tocris Bioscience
product type :
chemical
product name :
1201/1
catalog :
1201/1
quantity :
1 mg (also 5 mg)
price :
108 USD
more info or order :
citations: 35
Reference
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Geesala R, Schanz W, Biggs M, Dixit G, Skurski J, Gurung P, et al. Loss of RHBDF2 results in an early-onset spontaneous murine colitis. J Leukoc Biol. 2019;105:767-781 pubmed publisher
Schaffer T, Smith J, Cook E, Phan T, Margolis S. PKCε Inhibits Neuronal Dendritic Spine Development through Dual Phosphorylation of Ephexin5. Cell Rep. 2018;25:2470-2483.e8 pubmed publisher
Liu T, Shi Y, Chan M, Peng G, Zhang Q, Sun X, et al. Developmental protein kinase C hyper-activation results in microcephaly and behavioral abnormalities in zebrafish. Transl Psychiatry. 2018;8:232 pubmed publisher
Wong M, Hoekstra S, Vowles J, Watson L, Fuller G, Nemeth A, et al. Neurodegeneration in SCA14 is associated with increased PKCγ kinase activity, mislocalization and aggregation. Acta Neuropathol Commun. 2018;6:99 pubmed publisher
Arnold C, Demirel E, Feldner A, Genove G, Zhang H, Sticht C, et al. Hypertension-evoked RhoA activity in vascular smooth muscle cells requires RGS5. FASEB J. 2017;: pubmed publisher
Hosur V, Low B, Shultz L, Wiles M. Genetic deletion of amphiregulin restores the normal skin phenotype in a mouse model of the human skin disease tylosis. Biol Open. 2017;6:1174-1179 pubmed publisher
Quizon P, Sun W, Yuan Y, Midde N, Zhan C, Zhu J. Molecular mechanism: the human dopamine transporter histidine 547 regulates basal and HIV-1 Tat protein-inhibited dopamine transport. Sci Rep. 2016;6:39048 pubmed publisher
Lo Cicero A, Jaskowiak A, Egesipe A, Tournois J, Brinon B, Pitrez P, et al. A High Throughput Phenotypic Screening reveals compounds that counteract premature osteogenic differentiation of HGPS iPS-derived mesenchymal stem cells. Sci Rep. 2016;6:34798 pubmed publisher
Davis W. The ATP-Binding Cassette Transporter-2 (ABCA2) Overexpression Modulates Sphingosine Levels and Transcription of the Amyloid Precursor Protein (APP) Gene. Curr Alzheimer Res. 2015;12:847-59 pubmed
Tasoglu S, Khoory J, Tekin H, Thomas C, Karnoub A, Ghiran I, et al. Levitational Image Cytometry with Temporal Resolution. Adv Mater. 2015;27:3901-8 pubmed publisher
Hagen J, Zimmerman R, Goetz C, Bonnevier J, Houchins J, Reagan K, et al. Comparative Multi-Donor Study of IFNγ Secretion and Expression by Human PBMCs Using ELISPOT Side-by-Side with ELISA and Flow Cytometry Assays. Cells. 2015;4:84-95 pubmed publisher
Bemben M, Nguyen Q, Wang T, Li Y, Nicoll R, Roche K. Autism-associated mutation inhibits protein kinase C-mediated neuroligin-4X enhancement of excitatory synapses. Proc Natl Acad Sci U S A. 2015;112:2551-6 pubmed publisher
Brust T, Hayes M, Roman D, Watts V. New functional activity of aripiprazole revealed: Robust antagonism of D2 dopamine receptor-stimulated Gβγ signaling. Biochem Pharmacol. 2015;93:85-91 pubmed publisher
Yu Y, Zhang M, Zhang X, Cai Q, Zhu Z, Jiang W, et al. Transactivation of epidermal growth factor receptor through platelet-activating factor/receptor in ovarian cancer cells. J Exp Clin Cancer Res. 2014;33:85 pubmed publisher
Brown M, Dobrikov M, Gromeier M. Mitogen-activated protein kinase-interacting kinase regulates mTOR/AKT signaling and controls the serine/arginine-rich protein kinase-responsive type 1 internal ribosome entry site-mediated translation and viral oncolysis. J Virol. 2014;88:13149-60 pubmed publisher
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Li C, Peart N, Xuan Z, Lewis D, Xia Y, Jin J. PMA induces SnoN proteolysis and CD61 expression through an autocrine mechanism. Cell Signal. 2014;26:1369-78 pubmed publisher
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Kim S, Lee J, Lee S, Bae S, Kim J, Kim M, et al. Protein kinase C-? downregulates estrogen receptor-? by suppressing c-Jun phosphorylation in estrogen receptor-positive breast cancer cells. Oncol Rep. 2014;31:1423-8 pubmed publisher
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product information
master code :
1201
SKU :
1201/1
product name :
Phorbol 12-myristate 13-acetate
unit size :
1 mg (also 5 mg)
description :
Protein kinase C activator
target :
Protein Kinase C Activators
category :
Small Molecules
purity :
98%
observed molecular weight :
616.83
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Phorbol 12-myristate 13-acetate is an extensively used phorbol ester high affinity activator of protein kinase C (Ki = 2.6 nM as measured by displacement of [3H]phorbol 12,13-dibutyrate binding in rat cortex synaptosomal membranes). It binds to the C1a and C1b domains of PKC inducing membrane translocation of PKC. Phorbol 12-myristate 13-acetate activates the PKC isoforms PKC , - , - , - , - , - , and - but not PKC or - / . Phorbol 12-myristate 13-acetate is a tumor promoter. Phorbol 12-myristate 13-acetate can also induce differentiation of THP-1 monocytes to a macrophage phenotype in vitro .
top caption :
Protein kinase C activator
extended description :
Protein kinase C activator
chemical name text :
(1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-9a-(Acetyloxy)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulen-9-yl tetradecanoate
formula :
C36H56O8
formula text :
C36H56O8
cas num :
16561-29-8
USD :
108 USD
product details :
Protein kinase C activator
alt names :
PMA
storage :
Store at -20░C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK