NF 279 | Tocris Bioscience 1199 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

NF 279

catalog :

1199

quantity :

10 mg (also 50 mg)

price :

212 USD

more info or order :

Tocris Bioscience product webpage

citations: 9

Reference
Nishimura Y, McLaughlin N, Pan J, Goldstein S, Hafenstein S, Shimizu H, et al. The Suramin Derivative NF449 Interacts with the 5-fold Vertex of the Enterovirus A71 Capsid to Prevent Virus Attachment to PSGL-1 and Heparan Sulfate. PLoS Pathog. 2015;11:e1005184 pubmed publisher
Aliagas E, Vidal A, Texidó L, Ponce J, Condom E, Martín Satué M. High expression of ecto-nucleotidases CD39 and CD73 in human endometrial tumors. Mediators Inflamm. 2014;2014:509027 pubmed publisher
Aliagas E, Villar Menéndez I, Sevigny J, Roca M, Romeu M, Ferrer I, et al. Reduced striatal ecto-nucleotidase activity in schizophrenia patients supports the "adenosine hypothesis". Purinergic Signal. 2013;9:599-608 pubmed publisher
Hazleton J, Berman J, Eugenin E. Purinergic receptors are required for HIV-1 infection of primary human macrophages. J Immunol. 2012;188:4488-95 pubmed publisher
Ibáñez G, Shum D, Blum G, Bhinder B, Radu C, Antczak C, et al. A high throughput scintillation proximity imaging assay for protein methyltransferases. Comb Chem High Throughput Screen. 2012;15:359-71 pubmed
Donnelly Roberts D, Namovic M, Han P, Jarvis M. Mammalian P2X7 receptor pharmacology: comparison of recombinant mouse, rat and human P2X7 receptors. Br J Pharmacol. 2009;157:1203-14 pubmed publisher
Luke T, Hexum T. UTP and ATP increase extracellular signal-regulated kinase 1/2 phosphorylation in bovine chromaffin cells through epidermal growth factor receptor transactivation. Purinergic Signal. 2008;4:323-30 pubmed publisher
Kennedy C, Tasker P, Gallacher G, Westfall T. Identification of atropine- and P2X1 receptor antagonist-resistant, neurogenic contractions of the urinary bladder. J Neurosci. 2007;27:845-51 pubmed
Inscho E, Cook A, Imig J, Vial C, Evans R. Physiological role for P2X1 receptors in renal microvascular autoregulatory behavior. J Clin Invest. 2003;112:1895-905 pubmed

product information

brand :

Tocris

master code :

1199

SKU :

1199/10

product name :

NF 279

description :

Potent and selective P2X1 antagonist

target :

P2X Receptor Antagonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

observed molecular weight :

1401.1

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

A potent and selective P2X1 antagonist (IC50 = 19 nM). Displays good selectivity over P2X2,(IC50 = 0.76 u M), P2X3 (IC50 = 1.62 u M), P2X4 (IC50 300 u M), P2Y receptors and ecto-nucleotidases.

catalog number base :

1199

product keywords :

Potent selective P2X1 antagonists Receptors Purinergic purinoceptors NF279 P2X Receptors 1199,

extended description :

Potent and selective P2X1 antagonist

chemical name text :

8,8 -[Carbonylbis(imino-4,1-phenylenecarbonylimino-4,1-phenylenecarbonylimino)]bis-1,3,5-naphthalenetrisulfonic acid hexasodium salt

formula :

C 49 H 30 N 6 Na 6 O 23 S 6

formula text :

C49H30N6Na6O23S6

cas num :

202983-32-2

2020 USD :

203

2021 USD :

212 USD

storage :

Desiccate at -20°C

more info or order :

Tocris Bioscience product webpage