1199/10 | Tocris Bioscience 1199/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

1199/10

catalog :

1199/10

quantity :

10 mg (also 50 mg)

price :

267 USD

more info or order :

Tocris Bioscience product webpage

citations: 9

Reference
Nishimura Y, McLaughlin N, Pan J, Goldstein S, Hafenstein S, Shimizu H, et al. The Suramin Derivative NF449 Interacts with the 5-fold Vertex of the Enterovirus A71 Capsid to Prevent Virus Attachment to PSGL-1 and Heparan Sulfate. PLoS Pathog. 2015;11:e1005184 pubmed publisher
Aliagas E, Vidal A, Texidó L, Ponce J, Condom E, Martín Satué M. High expression of ecto-nucleotidases CD39 and CD73 in human endometrial tumors. Mediators Inflamm. 2014;2014:509027 pubmed publisher
Aliagas E, Villar Menéndez I, Sevigny J, Roca M, Romeu M, Ferrer I, et al. Reduced striatal ecto-nucleotidase activity in schizophrenia patients supports the "adenosine hypothesis". Purinergic Signal. 2013;9:599-608 pubmed publisher
Hazleton J, Berman J, Eugenin E. Purinergic receptors are required for HIV-1 infection of primary human macrophages. J Immunol. 2012;188:4488-95 pubmed publisher
Ibáñez G, Shum D, Blum G, Bhinder B, Radu C, Antczak C, et al. A high throughput scintillation proximity imaging assay for protein methyltransferases. Comb Chem High Throughput Screen. 2012;15:359-71 pubmed
Donnelly Roberts D, Namovic M, Han P, Jarvis M. Mammalian P2X7 receptor pharmacology: comparison of recombinant mouse, rat and human P2X7 receptors. Br J Pharmacol. 2009;157:1203-14 pubmed publisher
Luke T, Hexum T. UTP and ATP increase extracellular signal-regulated kinase 1/2 phosphorylation in bovine chromaffin cells through epidermal growth factor receptor transactivation. Purinergic Signal. 2008;4:323-30 pubmed publisher
Kennedy C, Tasker P, Gallacher G, Westfall T. Identification of atropine- and P2X1 receptor antagonist-resistant, neurogenic contractions of the urinary bladder. J Neurosci. 2007;27:845-51 pubmed
Inscho E, Cook A, Imig J, Vial C, Evans R. Physiological role for P2X1 receptors in renal microvascular autoregulatory behavior. J Clin Invest. 2003;112:1895-905 pubmed

product information

master code :

1199

SKU :

1199/10

product name :

NF 279

unit size :

10 mg (also 50 mg)

description :

Potent and selective P2X1 antagonist

target :

P2X Receptor Antagonists

category :

Small Molecules

purity :

95%

observed molecular weight :

1401.1

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

NF 279 is a a potent and selective P2X1 antagonist (IC50 = 19 nM). Displays good selectivity over P2X2,(IC50 = 0.76 u M), P2X3 (IC50 = 1.62 u M), P2X4 (IC50 300 u M), P2Y receptors and ecto-nucleotidases. . This product is supplied with a high degree of hydration and some residual NaCl, the amount of which are batch dependent. Please refer to the Certificate of Analysis to obtain the batch specific Net Product Content.

top caption :

Potent and selective P2X1 antagonist

extended description :

Potent and selective P2X1 antagonist

chemical name text :

8,8 -[Carbonylbis(imino-4,1-phenylenecarbonylimino-4,1-phenylenecarbonylimino)]bis-1,3,5-naphthalenetrisulfonic acid hexasodium salt

formula :

C49H30N6Na6O23S6

formula text :

C49H30N6Na6O23S6

cas num :

202983-32-2

USD :

267 USD

product details :

Potent and selective P2X1 antagonist

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage