product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
IRL-1620
catalog :
1196
quantity :
500 ug
price :
212 USD
more info or order :
citations: 8
Reference
Durgan D, Crossland R, Lloyd E, Phillips S, Bryan R. Increased cerebrovascular sensitivity to endothelin-1 in a rat model of obstructive sleep apnea: a role for endothelin receptor B. J Cereb Blood Flow Metab. 2015;35:402-11 pubmed publisher
Ou M, Dang Y, Mazzuca M, Basile R, Khalil R. Adaptive regulation of endothelin receptor type-A and type-B in vascular smooth muscle cells during pregnancy in rats. J Cell Physiol. 2014;229:489-501 pubmed publisher
Mazzuca M, Dang Y, Khalil R. Enhanced endothelin receptor type B-mediated vasodilation and underlying [Ca²?]i in mesenteric microvessels of pregnant rats. Br J Pharmacol. 2013;169:1335-51 pubmed publisher
Hamby M, Coppola G, Ao Y, Geschwind D, Khakh B, Sofroniew M. Inflammatory mediators alter the astrocyte transcriptome and calcium signaling elicited by multiple G-protein-coupled receptors. J Neurosci. 2012;32:14489-510 pubmed publisher
Choisy S, Cheng H, Smith G, James A, Hancox J. Modulation by endothelin-1 of spontaneous activity and membrane currents of atrioventricular node myocytes from the rabbit heart. PLoS ONE. 2012;7:e33448 pubmed publisher
Giachini F, Zemse S, Carneiro F, Lima V, Carneiro Z, Callera G, et al. Interleukin-10 attenuates vascular responses to endothelin-1 via effects on ERK1/2-dependent pathway. Am J Physiol Heart Circ Physiol. 2009;296:H489-96 pubmed publisher
McQueen D, Noble M, Bond S. Endothelin-1 activates ETA receptors to cause reflex scratching in BALB/c mice. Br J Pharmacol. 2007;151:278-84 pubmed
Khan H, Naylor R, Tuladhar B. Pharmacological characterization of endothelin receptors-mediated contraction in the mouse isolated proximal and distal colon. Br J Pharmacol. 2006;147:607-11 pubmed
product information
brand :
Tocris
master code :
1196
SKU :
1196/500U
product name :
IRL-1620
description :
Highly selective ETB agonist
target :
Endothelin ETB Receptor Agonists
category :
Peptides
unit size :
500 ug
observed molecular weight :
1820
url print :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=peptides
details of functionality :
Highly selective ETB endothelin receptor agonist (Ki values are 0.016 and 1900 nM at ETB and ETA receptors respectively). Discriminates two subpopulations of ETB receptors.
catalog number base :
1196
product keywords :
selective ETB agonists Receptors Endothelin Endothelin ETB Receptors 1196,
extended description :
Highly selective ETB agonist
formula :
C 86 H 117 N 17 O 27
formula text :
C86H117N17O27
cas num :
142569-99-1
2020 USD :
205
2021 USD :
212 USD
storage :
Desiccate at -20°C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK