IRL-1620 | Tocris Bioscience 1196/500U product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

IRL-1620

catalog :

1196/500U

quantity :

500 ug

price :

264 USD

citations: 8

Reference
Durgan D, Crossland R, Lloyd E, Phillips S, Bryan R. Increased cerebrovascular sensitivity to endothelin-1 in a rat model of obstructive sleep apnea: a role for endothelin receptor B. J Cereb Blood Flow Metab. 2015;35:402-11 pubmed publisher
Ou M, Dang Y, Mazzuca M, Basile R, Khalil R. Adaptive regulation of endothelin receptor type-A and type-B in vascular smooth muscle cells during pregnancy in rats. J Cell Physiol. 2014;229:489-501 pubmed publisher
Mazzuca M, Dang Y, Khalil R. Enhanced endothelin receptor type B-mediated vasodilation and underlying [Ca²?]i in mesenteric microvessels of pregnant rats. Br J Pharmacol. 2013;169:1335-51 pubmed publisher
Hamby M, Coppola G, Ao Y, Geschwind D, Khakh B, Sofroniew M. Inflammatory mediators alter the astrocyte transcriptome and calcium signaling elicited by multiple G-protein-coupled receptors. J Neurosci. 2012;32:14489-510 pubmed publisher
Choisy S, Cheng H, Smith G, James A, Hancox J. Modulation by endothelin-1 of spontaneous activity and membrane currents of atrioventricular node myocytes from the rabbit heart. PLoS ONE. 2012;7:e33448 pubmed publisher
Giachini F, Zemse S, Carneiro F, Lima V, Carneiro Z, Callera G, et al. Interleukin-10 attenuates vascular responses to endothelin-1 via effects on ERK1/2-dependent pathway. Am J Physiol Heart Circ Physiol. 2009;296:H489-96 pubmed publisher
McQueen D, Noble M, Bond S. Endothelin-1 activates ETA receptors to cause reflex scratching in BALB/c mice. Br J Pharmacol. 2007;151:278-84 pubmed
Khan H, Naylor R, Tuladhar B. Pharmacological characterization of endothelin receptors-mediated contraction in the mouse isolated proximal and distal colon. Br J Pharmacol. 2006;147:607-11 pubmed

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

1196

SKU :

1196/500U

product name :

IRL-1620

Description :

Highly selective ETB agonist

target :

Endothelin ETB Receptor Agonists

category :

Peptides

unit size :

500 ug

purity :

95%

observed molecular weight :

1820

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=peptides

details of functionality :

IRL-1620 is a potent and highly selective ETB endothelin receptor agonist (Ki values are 0.016 and 1900 nM at ETB and ETA receptors respectively). Discriminates two subpopulations of ETB receptors. IRL-1620 prevents oxidative stress and cognitive impairment induced by A in normal and diabetic rats; in a rat brain ischemia model it is neuroprotective, increases angiogenesis and neurogenesis, and promotes the recovery of neuronal function. Also promotes neural progenitor cell differentiation and maturation in vivo and in vitro .

extended description :

Highly selective ETB agonist

formula :

C 86 H 117 N 17 O 27

formula text :

C86H117N17O27

cas num :

142569-99-1

USD :

264 USD

product details :

Highly selective ETB agonist

storage :

Store at -20°C