product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
1188/500U
catalog :
1188/500U
quantity :
500 ug
price :
251 USD
more info or order :
citations: 7
Reference
Patel C, Narayanan S, Zhang W, Xu Z, Sukumari Ramesh S, Dhandapani K, et al. Activation of the endothelin system mediates pathological angiogenesis during ischemic retinopathy. Am J Pathol. 2014;184:3040-51 pubmed publisher
Sanchez A, Martinez P, Munoz M, Benedito S, Garcia Sacristan A, Hernandez M, et al. Endothelin-1 contributes to endothelial dysfunction and enhanced vasoconstriction through augmented superoxide production in penile arteries from insulin-resistant obese rats: role of ET(A) and ET(B) receptors. Br J Pharmacol. 2014;171:5682-95 pubmed publisher
Faraco G, Wijasa T, Park L, Moore J, Anrather J, Iadecola C. Water deprivation induces neurovascular and cognitive dysfunction through vasopressin-induced oxidative stress. J Cereb Blood Flow Metab. 2014;34:852-60 pubmed publisher
Ou M, Dang Y, Mazzuca M, Basile R, Khalil R. Adaptive regulation of endothelin receptor type-A and type-B in vascular smooth muscle cells during pregnancy in rats. J Cell Physiol. 2014;229:489-501 pubmed publisher
Mazzuca M, Dang Y, Khalil R. Enhanced endothelin receptor type B-mediated vasodilation and underlying [Ca²?]i in mesenteric microvessels of pregnant rats. Br J Pharmacol. 2013;169:1335-51 pubmed publisher
Craig J, Martin W. Dominance of flow-mediated constriction over flow-mediated dilatation in the rat carotid artery. Br J Pharmacol. 2012;167:527-36 pubmed publisher
McQueen D, Noble M, Bond S. Endothelin-1 activates ETA receptors to cause reflex scratching in BALB/c mice. Br J Pharmacol. 2007;151:278-84 pubmed
product information
master code :
1188
SKU :
1188/500U
product name :
BQ-123
unit size :
500 ug
description :
Selective ETA antagonist
target :
Endothelin ETA Receptor Antagonists
category :
Peptides
purity :
95%
observed molecular weight :
611
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=peptides
details of functionality :
BQ-123 is a selective ETA endothelin receptor antagonist (Ki values are 1.4 and 1500 nM at ETA and ETB receptors respectively). Reduces ischemia-induced ventricular arrhythmias in a rat model.
top caption :
Selective ETA antagonist
extended description :
Selective ETA antagonist
formula :
C31H42N6O7
formula text :
C31H42N6O7
cas num :
136553-81-6
USD :
251 USD
product details :
Selective ETA antagonist
storage :
Store at -20░C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK