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company name :
Tocris Bioscience
product type :
chemical
product name :
1171/1
catalog :
1171/1
quantity :
1 mg
price :
106 USD
more info or order :
citations: 39
Reference
Nam M, Han K, Lee J, Won W, Koh W, Bae J, et al. Activation of Astrocytic μ-Opioid Receptor Causes Conditioned Place Preference. Cell Rep. 2019;28:1154-1166.e5 pubmed publisher
Akoume M, Elbakry M, Veillette M, Franco A, Nada D, Labelle H, et al. A Differential Hypofunctionality of Gαi Proteins Occurs in Adolescent Idiopathic Scoliosis and Correlates with the Risk of Disease Progression. Sci Rep. 2019;9:10074 pubmed publisher
Nasrallah K, Therreau L, Robert V, Huang A, McHugh T, Piskorowski R, et al. Routing Hippocampal Information Flow through Parvalbumin Interneuron Plasticity in Area CA2. Cell Rep. 2019;27:86-98.e3 pubmed publisher
Dai W, Liu X, Bao Y, Yan B, Jiang N, Yu B, et al. Selective blockade of spinal D2DR by levo-corydalmine attenuates morphine tolerance via suppressing PI3K/Akt-MAPK signaling in a MOR-dependent manner. Exp Mol Med. 2018;50:148 pubmed publisher
Dziedowiec E, Nayak S, Gruver K, Jennings T, Tallarida C, Rawls S. Mu Opioid Receptor Agonist DAMGO Produces Place Conditioning, Abstinence-induced Withdrawal, and Naltrexone-Dependent Locomotor Activation in Planarians. Neuroscience. 2018;386:214-222 pubmed publisher
Bao F, Li C, Chen X, Lu Y, Bao L, Zhang X. Clinical opioids differentially induce co-internalization of μ- and δ-opioid receptors. Mol Pain. 2018;14:1744806918769492 pubmed publisher
Montandon G, Wu H, Liu H, Vu M, Orser B, Horner R. δ-Subunit Containing GABAA Receptors Modulate Respiratory Networks. Sci Rep. 2017;7:18105 pubmed publisher
Schmid C, Kennedy N, Ross N, Lovell K, Yue Z, Morgenweck J, et al. Bias Factor and Therapeutic Window Correlate to Predict Safer Opioid Analgesics. Cell. 2017;171:1165-1175.e13 pubmed publisher
Ford B, Franks L, Tai S, Fantegrossi W, Stahl E, Berquist M, et al. Characterization of structurally novel G protein biased CB1 agonists: Implications for drug development. Pharmacol Res. 2017;125:161-177 pubmed publisher
Ye Y, Bernabé D, Salvo E, Viet C, Ono K, Dolan J, et al. Alterations in opioid inhibition cause widespread nociception but do not affect anxiety-like behavior in oral cancer mice. Neuroscience. 2017;363:50-61 pubmed publisher
Lei W, Mullen N, McCarthy S, Brann C, Richard P, Cormier J, et al. Heat-shock protein 90 (Hsp90) promotes opioid-induced anti-nociception by an ERK mitogen-activated protein kinase (MAPK) mechanism in mouse brain. J Biol Chem. 2017;292:10414-10428 pubmed publisher
Mamaligas A, Cai Y, Ford C. Nicotinic and opioid receptor regulation of striatal dopamine D2-receptor mediated transmission. Sci Rep. 2016;6:37834 pubmed publisher
Liu C, Lee M, Yang C, Chen C, Min M, Yang H. Morphological and physiological evidence of a synaptic connection between the lateral parabrachial nucleus and neurons in the A7 catecholamine cell group in rats. J Biomed Sci. 2015;22:79 pubmed publisher
Wang P, Ho I, Lee C. Buprenorphine-elicited alteration of adenylate cyclase activity in human embryonic kidney 293 cells coexpressing κ-, μ-opioid and nociceptin receptors. J Cell Mol Med. 2015;19:2587-96 pubmed publisher
Taylor A, Castonguay A, Taylor A, Murphy N, Ghogha A, Cook C, et al. Microglia disrupt mesolimbic reward circuitry in chronic pain. J Neurosci. 2015;35:8442-50 pubmed publisher
Bai X, Zhang X, Li Y, Lu L, Li B, He X. Sex differences in peripheral mu-opioid receptor mediated analgesia in rat orofacial persistent pain model. PLoS ONE. 2015;10:e0122924 pubmed publisher
Beaudry H, Mercier Blais A, Delaygue C, Lavoie C, Parent J, Neugebauer W, et al. Regulation of μ and δ opioid receptor functions: involvement of cyclin-dependent kinase 5. Br J Pharmacol. 2015;172:2573-87 pubmed publisher
Brewer K, Baran C, Whitfield B, Jensen A, Clemens S. Dopamine D3 receptor dysfunction prevents anti-nociceptive effects of morphine in the spinal cord. Front Neural Circuits. 2014;8:62 pubmed publisher
Ong E, Xue L, Olmstead M, Cahill C. Prolonged morphine treatment alters ? opioid receptor post-internalization trafficking. Br J Pharmacol. 2015;172:615-29 pubmed publisher
Chen W, McRoberts J, Marvizón J. ?-Opioid receptor inhibition of substance P release from primary afferents disappears in neuropathic pain but not inflammatory pain. Neuroscience. 2014;267:67-82 pubmed publisher
Zhou L, Lovell K, Frankowski K, Slauson S, Phillips A, Streicher J, et al. Development of functionally selective, small molecule agonists at kappa opioid receptors. J Biol Chem. 2013;288:36703-16 pubmed publisher
Vicente Sánchez A, Sánchez Blázquez P, Rodríguez Muñoz M, Garzón J. HINT1 protein cooperates with cannabinoid 1 receptor to negatively regulate glutamate NMDA receptor activity. Mol Brain. 2013;6:42 pubmed publisher
Kharmate G, Rajput P, Lin Y, Kumar U. Inhibition of tumor promoting signals by activation of SSTR2 and opioid receptors in human breast cancer cells. Cancer Cell Int. 2013;13:93 pubmed publisher
Rajasekaran M, Brents L, Franks L, Moran J, Prather P. Human metabolites of synthetic cannabinoids JWH-018 and JWH-073 bind with high affinity and act as potent agonists at cannabinoid type-2 receptors. Toxicol Appl Pharmacol. 2013;269:100-8 pubmed publisher
Morse M, Sun H, Tran E, Levenson R, Fang Y. Label-free integrative pharmacology on-target of opioid ligands at the opioid receptor family. BMC Pharmacol Toxicol. 2013;14:17 pubmed publisher
Sarkar D, Sengupta A, Zhang C, Boyadjieva N, Murugan S. Opiate antagonist prevents μ- and δ-opiate receptor dimerization to facilitate ability of agonist to control ethanol-altered natural killer cell functions and mammary tumor growth. J Biol Chem. 2012;287:16734-47 pubmed publisher
Krook Magnuson E, Luu L, Lee S, Varga C, Soltesz I. Ivy and neurogliaform interneurons are a major target of ?-opioid receptor modulation. J Neurosci. 2011;31:14861-70 pubmed publisher
Gruol D, Nelson T, Hao C, Michael S, Vukojevic V, Ming Y, et al. Ethanol alters opioid regulation of Ca(2+) influx through L-type Ca(2+) channels in PC12 cells. Alcohol Clin Exp Res. 2012;36:443-56 pubmed publisher
Morse M, Tran E, Sun H, Levenson R, Fang Y. Ligand-directed functional selectivity at the mu opioid receptor revealed by label-free integrative pharmacology on-target. PLoS ONE. 2011;6:e25643 pubmed publisher
Reyes B, Vakharia K, Ferraro T, Levenson R, Berrettini W, van Bockstaele E. Opiate agonist-induced re-distribution of Wntless, a mu-opioid receptor interacting protein, in rat striatal neurons. Exp Neurol. 2012;233:205-13 pubmed publisher
Beaudry H, Dubois D, Gendron L. Activation of spinal mu- and delta-opioid receptors potently inhibits substance P release induced by peripheral noxious stimuli. J Neurosci. 2011;31:13068-77 pubmed publisher
Lee C, Yan J, Chiang Y, Hung T, Wang H, Chiou L, et al. Differential pharmacological actions of methadone and buprenorphine in human embryonic kidney 293 cells coexpressing human ?-opioid and opioid receptor-like 1 receptors. Neurochem Res. 2011;36:2008-21 pubmed publisher
Nassirpour R, Bahima L, Lalive A, Lüscher C, Lujan R, Slesinger P. Morphine- and CaMKII-dependent enhancement of GIRK channel signaling in hippocampal neurons. J Neurosci. 2010;30:13419-30 pubmed publisher
Wang H, Zhao B, Zhong Y, Li K, Li Z, Wang Q, et al. Coexpression of delta- and mu-opioid receptors in nociceptive sensory neurons. Proc Natl Acad Sci U S A. 2010;107:13117-22 pubmed publisher
Lorier A, Funk G, Greer J. Opiate-induced suppression of rat hypoglossal motoneuron activity and its reversal by ampakine therapy. PLoS ONE. 2010;5:e8766 pubmed publisher
Hull L, Llorente J, Gabra B, Smith F, Kelly E, Bailey C, et al. The effect of protein kinase C and G protein-coupled receptor kinase inhibition on tolerance induced by mu-opioid agonists of different efficacy. J Pharmacol Exp Ther. 2010;332:1127-35 pubmed publisher
Maione S, Starowicz K, Cristino L, Guida F, Palazzo E, Luongo L, et al. Functional interaction between TRPV1 and mu-opioid receptors in the descending antinociceptive pathway activates glutamate transmission and induces analgesia. J Neurophysiol. 2009;101:2411-22 pubmed publisher
Garzón J, de la Torre Madrid E, Rodríguez Muñoz M, Vicente Sánchez A, Sánchez Blázquez P. Gz mediates the long-lasting desensitization of brain CB1 receptors and is essential for cross-tolerance with morphine. Mol Pain. 2009;5:11 pubmed publisher
Kokkola T, Savinainen J, Mönkkönen K, Retamal M, Laitinen J. S-nitrosothiols modulate G protein-coupled receptor signaling in a reversible and highly receptor-specific manner. BMC Cell Biol. 2005;6:21 pubmed
product information
master code :
1171
SKU :
1171/1
product name :
DAMGO
unit size :
1 mg
description :
Selective agonist
target :
mu Opioid Receptor Agonists
category :
Peptides
purity :
95%
observed molecular weight :
513.7
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=peptides
details of functionality :
DAMGO is a highly selective peptide agonist for the u opioid receptor.
top caption :
Selective agonist
extended description :
Selective agonist
chemical name text :
[D-Ala2, NMe-Phe4, Gly-ol5]-enkephalin
formula :
C26H35N5O6
formula text :
C26H35N5O6
cas num :
78123-71-4
USD :
106 USD
product details :
Selective agonist
alt names :
DAGO
storage :
Store at -20░C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK