1160/100U | Tocris Bioscience 1160/100U product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

1160/100U

catalog :

1160/100U

quantity :

100 ug

price :

276 USD

more info or order :

Tocris Bioscience product webpage

citations: 18

Reference
Cheng R, Feng Y, Liu D, Wang Z, Zhang J, Chen L, et al. The role of Nav1.7 and methylglyoxal-mediated activation of TRPA1 in itch and hypoalgesia in a murine model of type 1 diabetes. Theranostics. 2019;9:4287-4307 pubmed publisher
Ban Y, Liu Y, Li Y, Zhang Y, Xiao L, Gu Y, et al. S-nitrosation impairs KLF4 activity and instigates endothelial dysfunction in pulmonary arterial hypertension. Redox Biol. 2019;21:101099 pubmed publisher
Yuan L, Liang T, Deng J, Sun Y. Dynamics and Functional Role of Dopaminergic Neurons in the Ventral Tegmental Area during Itch Processing. J Neurosci. 2018;38:9856-9869 pubmed publisher
Zhuang R, Wu J, Lin F, Han L, Liang X, Meng Q, et al. Fasudil preserves lung endothelial function and reduces pulmonary vascular remodeling in a rat model of end‑stage pulmonary hypertension with left heart disease. Int J Mol Med. 2018;42:1341-1352 pubmed publisher
Zhang M, Guo F, Wu H, Yu Y, Wei J, Wang S, et al. DanHong injection targets endothelin receptor type B and angiotensin II receptor type 1 in protection against cardiac hypertrophy. Oncotarget. 2017;8:103393-103409 pubmed publisher
Schafer S, Viswanathan S, Widjaja A, Lim W, Moreno Moral A, Delaughter D, et al. IL-11 is a crucial determinant of cardiovascular fibrosis. Nature. 2017;552:110-115 pubmed publisher
Zheng C, Lo C, Meng Z, Li Z, Zhong M, Zhang P, et al. Gastrodin Inhibits Store-Operated Ca2+ Entry and Alleviates Cardiac Hypertrophy. Front Pharmacol. 2017;8:222 pubmed publisher
Kiguchi N, Sukhtankar D, Ding H, Tanaka K, Kishioka S, Peters C, et al. Spinal Functions of B-Type Natriuretic Peptide, Gastrin-Releasing Peptide, and Their Cognate Receptors for Regulating Itch in Mice. J Pharmacol Exp Ther. 2016;356:596-603 pubmed publisher
Yuan X, Eng G, Arkonac D, Chao P, Vunjak Novakovic G. Endothelial cells enhance the migration of bovine meniscus cells. Arthritis Rheumatol. 2015;67:182-92 pubmed publisher
Sanchez A, Martinez P, Munoz M, Benedito S, Garcia Sacristan A, Hernandez M, et al. Endothelin-1 contributes to endothelial dysfunction and enhanced vasoconstriction through augmented superoxide production in penile arteries from insulin-resistant obese rats: role of ET(A) and ET(B) receptors. Br J Pharmacol. 2014;171:5682-95 pubmed publisher
Needham M, McGahon M, Bankhead P, Gardiner T, Scholfield C, Curtis T, et al. The role of K+ and Cl- channels in the regulation of retinal arteriolar tone and blood flow. Invest Ophthalmol Vis Sci. 2014;55:2157-65 pubmed publisher
Bellono N, Najera J, Oancea E. UV light activates a G?q/11-coupled phototransduction pathway in human melanocytes. J Gen Physiol. 2014;143:203-14 pubmed publisher
Hamby M, Coppola G, Ao Y, Geschwind D, Khakh B, Sofroniew M. Inflammatory mediators alter the astrocyte transcriptome and calcium signaling elicited by multiple G-protein-coupled receptors. J Neurosci. 2012;32:14489-510 pubmed publisher
Suri S, Liu X, Rayment S, Hughes D, Kroon P, Needs P, et al. Quercetin and its major metabolites selectively modulate cyclic GMP-dependent relaxations and associated tolerance in pig isolated coronary artery. Br J Pharmacol. 2010;159:566-75 pubmed publisher
Giachini F, Zemse S, Carneiro F, Lima V, Carneiro Z, Callera G, et al. Interleukin-10 attenuates vascular responses to endothelin-1 via effects on ERK1/2-dependent pathway. Am J Physiol Heart Circ Physiol. 2009;296:H489-96 pubmed publisher
McQueen D, Noble M, Bond S. Endothelin-1 activates ETA receptors to cause reflex scratching in BALB/c mice. Br J Pharmacol. 2007;151:278-84 pubmed
Khan H, Naylor R, Tuladhar B. Pharmacological characterization of endothelin receptors-mediated contraction in the mouse isolated proximal and distal colon. Br J Pharmacol. 2006;147:607-11 pubmed
Cirino G, Sorrentino R, di Villa Bianca R, Popolo A, Palmieri A, Imbimbo C, et al. Involvement of beta 3-adrenergic receptor activation via cyclic GMP- but not NO-dependent mechanisms in human corpus cavernosum function. Proc Natl Acad Sci U S A. 2003;100:5531-6 pubmed

product information

master code :

1160

SKU :

1160/100U

product name :

Endothelin 1 (human, porcine)

unit size :

100 ug

description :

Potent vasoconstrictor peptide

target :

Non-selective Endothelin Receptor Agonists

category :

Peptides

purity :

95%

species :

Human, Porcine

observed molecular weight :

2492

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=peptides

details of functionality :

Endothelin 1 (human, porcine) is a potent endogenous peptide agonist at ETA and ETB receptors. Produces strong vasoconstriction and pressor responses. Competitive binding assay shows that Endothelin 1 reversibly binds to receptors (IC50 values are 0.12 nM and 0.15 nM at ETB and ETA receptors respectively). Potency is dependent on blood vessel type (EC50 ranges from 2.72 nM - 17.4 nM). Activates PLC (EC50 = 0.3 nM), increases production of PGE2 (EC50 = 12 nM) and induces intracellular calcium release in human ciliary muscle cells. Also upregulates leptin mRNA expression and secretion in adipocytes (EC50 = 8.8 nM).

top caption :

Potent vasoconstrictor peptide

extended description :

Potent vasoconstrictor peptide

formula :

C109H159O32N25S5

formula text :

C109H159O32N25S5

cas num :

117399-94-7

USD :

276 USD

product details :

Potent vasoconstrictor peptide

alt names :

ET-1

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage