product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
SKF 96365 hydrochloride
catalog :
1147
quantity :
10 mg (also 50 mg)
price :
195 USD
more info or order :
citations: 14
Reference
Sahu B, Rodriguez P, Nguyen M, Han R, Cero C, Razzoli M, et al. Peptide/Receptor Co-evolution Explains the Lipolytic Function of the Neuropeptide TLQP-21. Cell Rep. 2019;28:2567-2580.e6 pubmed publisher
Kubota H, Nagao S, Obata K, Hirono M. mGluR1-mediated excitation of cerebellar GABAergic interneurons requires both G protein-dependent and Src-ERK1/2-dependent signaling pathways. PLoS ONE. 2014;9:e106316 pubmed publisher
Alkhani H, Ase A, Grant R, O donnell D, Groschner K, Séguéla P. Contribution of TRPC3 to store-operated calcium entry and inflammatory transductions in primary nociceptors. Mol Pain. 2014;10:43 pubmed publisher
Soltoff S, Lannon W. Activation of ERK1/2 by store-operated calcium entry in rat parotid acinar cells. PLoS ONE. 2013;8:e72881 pubmed publisher
Hutchins B, Klenke U, Wray S. Calcium release-dependent actin flow in the leading process mediates axophilic migration. J Neurosci. 2013;33:11361-71 pubmed publisher
Fu L, van den Pol A. Kisspeptin directly excites anorexigenic proopiomelanocortin neurons but inhibits orexigenic neuropeptide Y cells by an indirect synaptic mechanism. J Neurosci. 2010;30:10205-19 pubmed publisher
Ben Mabrouk F, Tryba A. Substance P modulation of TRPC3/7 channels improves respiratory rhythm regularity and ICAN-dependent pacemaker activity. Eur J Neurosci. 2010;31:1219-32 pubmed publisher
Kyriazis G, Belal C, Madan M, Taylor D, Wang J, Wei Z, et al. Stress-induced switch in Numb isoforms enhances Notch-dependent expression of subtype-specific transient receptor potential channel. J Biol Chem. 2010;285:6811-25 pubmed publisher
Szikra T, Barabas P, Bartoletti T, Huang W, Akopian A, Thoreson W, et al. Calcium homeostasis and cone signaling are regulated by interactions between calcium stores and plasma membrane ion channels. PLoS ONE. 2009;4:e6723 pubmed publisher
Hildebrand M, Isope P, Miyazaki T, Nakaya T, Garcia E, Feltz A, et al. Functional coupling between mGluR1 and Cav3.1 T-type calcium channels contributes to parallel fiber-induced fast calcium signaling within Purkinje cell dendritic spines. J Neurosci. 2009;29:9668-82 pubmed publisher
Shin J, Kim Y, Linden D. Dendritic glutamate release produces autocrine activation of mGluR1 in cerebellar Purkinje cells. Proc Natl Acad Sci U S A. 2008;105:746-50 pubmed publisher
Huang Y, Sinha S, Tanaka K, Rothstein J, Bergles D. Astrocyte glutamate transporters regulate metabotropic glutamate receptor-mediated excitation of hippocampal interneurons. J Neurosci. 2004;24:4551-9 pubmed
Moneer Z, Dyer J, Taylor C. Nitric oxide co-ordinates the activities of the capacitative and non-capacitative Ca2+-entry pathways regulated by vasopressin. Biochem J. 2003;370:439-48 pubmed
Lim D, Kyozuka K, Gragnaniello G, Carafoli E, Santella L. NAADP+ initiates the Ca2+ response during fertilization of starfish oocytes. FASEB J. 2001;15:2257-67 pubmed
product information
brand :
Tocris
master code :
1147
SKU :
1147/10
product name :
SKF 96365 hydrochloride
description :
TRPC channel blocker; also inhibits store-operated Ca2+ entry
target :
TRPC Channel Blockers
category :
Small Molecules
unit size :
10 mg (also 50 mg)
purity :
99%
observed molecular weight :
402.92
url print :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Store-operated Ca2+ entry (SOCE) inhibitor that inhibits STIM1. Also blocks TRPC channels, voltage-gated Ca2+ channels and potassium channels.
catalog number base :
1147
product keywords :
STIM1-mediated Ca2+ influx inhibitos receptor-mediated entry Store Operated Calcium Channels STIM-Orai Signaling Signalling Agents General SKF96365 hydrochloride General Calcium Signaling Agents STIM-Orai Channels TRPC 1147,
extended description :
TRPC channel blocker; also inhibits store-operated Ca2+ entry
chemical name text :
1-[2-(4-Methoxyphenyl)-2-[3-(4-methoxyphenyl)propoxy]ethyl-1H-imidazole hydrochloride
formula :
C 22 H 26 N 2 O 3 .HCl
formula text :
C22H26N2O3.HCl
cas num :
130495-35-1
2020 USD :
187
2021 USD :
195 USD
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK