| Reference |
|---|
Li X, Matsuura T, Xue M, Chen Q, Liu R, Lu J, et al. Oxytocin in the anterior cingulate cortex attenuates neuropathic pain and emotional anxiety by inhibiting presynaptic long-term potentiation. Cell Rep. 2021;36:109411 pubmed publisher |
Hui Z, Jiang Z, Qiao D, Bo Z, Qiyuan K, Shaohua B, et al. Increased expression of LCN2 formed a positive feedback loop with activation of the ERK pathway in human kidney cells during kidney stone formation. Sci Rep. 2020;10:21287 pubmed publisher |
Furue K, Ito T, Tsuji G, Nakahara T, Furue M. Scratch wound-induced CXCL8 upregulation is EGFR-dependent in keratinocytes. J Dermatol Sci. 2020;: pubmed publisher |
Furue K, Ito T, Tanaka Y, Hashimoto Hachiya A, Takemura M, Murata M, et al. The EGFR-ERK/JNK-CCL20 Pathway in Scratched Keratinocytes May Underpin Koebnerization in Psoriasis Patients. Int J Mol Sci. 2020;21: pubmed publisher |
Devocelle A, Lecru L, Francois H, Desterke C, Gallerne C, Eid P, et al. Inhibition of TGF-β1 Signaling by IL-15: A Novel Role for IL-15 in the Control of Renal Epithelial-Mesenchymal Transition: IL-15 Counteracts TGF-β1-Induced EMT in Renal Fibrosis. Int J Cell Biol. 2019;2019:9151394 pubmed publisher |
Domin H, Piergies N, Pięta E, Wyska E, Pochwat B, Wlaz P, et al. Characterization of the Brain Penetrant Neuropeptide Y Y2 Receptor Antagonist SF-11. ACS Chem Neurosci. 2019;10:3454-3463 pubmed publisher |
Szybowska P, Kostas M, Wesche J, Wiedlocha A, Haugsten E. Cancer Mutations in FGFR2 Prevent a Negative Feedback Loop Mediated by the ERK1/2 Pathway. Cells. 2019;8: pubmed publisher |
Pietak A, Bischof J, LaPalme J, Morokuma J, Levin M. Neural control of body-plan axis in regenerating planaria. PLoS Comput Biol. 2019;15:e1006904 pubmed publisher |
Suo N, Guo Y, He B, Gu H, Xie X. Inhibition of MAPK/ERK pathway promotes oligodendrocytes generation and recovery of demyelinating diseases. Glia. 2019;67:1320-1332 pubmed publisher |
Ernst D, Williams B, Wang X, Yoon N, Kim K, Chiu J, et al. Humanized anti-CD123 antibody facilitates NK cell antibody-dependent cell-mediated cytotoxicity (ADCC) of Hodgkin lymphoma targets via ARF6/PLD-1. Blood Cancer J. 2019;9:6 pubmed publisher |
Cagnetta R, Wong H, Frese C, Mallucci G, Krijgsveld J, Holt C. Noncanonical Modulation of the eIF2 Pathway Controls an Increase in Local Translation during Neural Wiring. Mol Cell. 2019;73:474-489.e5 pubmed publisher |
Kim C, Hu B, Jadhav R, Jin J, Zhang H, Cavanagh M, et al. Activation of miR-21-Regulated Pathways in Immune Aging Selects against Signatures Characteristic of Memory T Cells. Cell Rep. 2018;25:2148-2162.e5 pubmed publisher |
Zhen A, Piao M, Hyun Y, Kang K, Ryu Y, Cho S, et al. Purpurogallin Protects Keratinocytes from Damage and Apoptosis Induced by Ultraviolet B Radiation and Particulate Matter 2.5. Biomol Ther (Seoul). 2019;27:395-403 pubmed publisher |
Andersson P, Yang Y, Hosaka K, Zhang Y, Fischer C, Braun H, et al. Molecular mechanisms of IL-33-mediated stromal interactions in cancer metastasis. JCI Insight. 2018;3: pubmed publisher |
Lin R, Wu I, Hong J, Liu B, Liang R, Yuan T, et al. Capsaicin-induced TRIB3 upregulation promotes apoptosis in cancer cells. Cancer Manag Res. 2018;10:4237-4248 pubmed publisher |
Collar A, Swamydas M, O Hayre M, Sajib M, Hoffman K, Singh S, et al. The homozygous CX3CR1-M280 mutation impairs human monocyte survival. JCI Insight. 2018;3: pubmed publisher |
Zhang Q, Lee W, Kang J, Kim L, Kim Y. Integrin CD11b negatively regulates Mincle-induced signaling via the Lyn-SIRPα-SHP1 complex. Exp Mol Med. 2018;50:e439 pubmed publisher |
Noskovičová N, Heinzelmann K, Burgstaller G, Behr J, Eickelberg O. Cub domain-containing protein 1 negatively regulates TGF-β signaling and myofibroblast differentiation. Am J Physiol Lung Cell Mol Physiol. 2018;314:L695-L707 pubmed publisher |
Li Z, Levine K, Bahreini A, Wang P, Chu D, Park B, et al. Upregulation of IRS1 Enhances IGF1 Response in Y537S and D538G ESR1 Mutant Breast Cancer Cells. Endocrinology. 2018;159:285-296 pubmed publisher |
Shen Z, Chen Y, Hong L, Cui Z, Yang H, He X, et al. BNGR-A25L and -A27 are two functional G protein-coupled receptors for CAPA periviscerokinin neuropeptides in the silkworm Bombyx mori. J Biol Chem. 2017;292:16554-16570 pubmed publisher |
Huang B, Chen T, Bau D, Chuang I, Tsai C, Chang P, et al. EGFR is a pivotal regulator of thrombin-mediated inflammation in primary human nucleus pulposus culture. Sci Rep. 2017;7:8578 pubmed publisher |
He Y, Taylor N, Fourgeaud L, Bhattacharya A. The role of microglial P2X7: modulation of cell death and cytokine release. J Neuroinflammation. 2017;14:135 pubmed publisher |
Gillman A, Breshears L, Kistler C, Finnegan P, Torres V, Schlievert P, et al. Epidermal Growth Factor Receptor Signaling Enhances the Proinflammatory Effects of Staphylococcus aureus Gamma-Toxin on the Mucosa. Toxins (Basel). 2017;9: pubmed publisher |
Wang H, Liu S, Liu S, Wei W, Zhou X, Lin F, et al. Enhanced expression and phosphorylation of Sirt7 activates smad2 and ERK signaling and promotes the cardiac fibrosis differentiation upon angiotensin-II stimulation. PLoS ONE. 2017;12:e0178530 pubmed publisher |
Kumar R, Gont A, Perkins T, Hanson J, Lorimer I. Induction of senescence in primary glioblastoma cells by serum and TGFβ. Sci Rep. 2017;7:2156 pubmed publisher |
Lei W, Mullen N, McCarthy S, Brann C, Richard P, Cormier J, et al. Heat-shock protein 90 (Hsp90) promotes opioid-induced anti-nociception by an ERK mitogen-activated protein kinase (MAPK) mechanism in mouse brain. J Biol Chem. 2017;292:10414-10428 pubmed publisher |
Wan J, Goldman D. Opposing Actions of Fgf8a on Notch Signaling Distinguish Two Muller Glial Cell Populations that Contribute to Retina Growth and Regeneration. Cell Rep. 2017;19:849-862 pubmed publisher |
Wu I, Lin R, Wang H, Yuan T, Chuang S. TRIB3 downregulation enhances doxorubicin-induced cytotoxicity in gastric cancer cells. Arch Biochem Biophys. 2017;622:26-35 pubmed publisher |
Baranova I, Souza A, Bocharov A, Vishnyakova T, Hu X, Vaisman B, et al. Human SR-BII mediates SAA uptake and contributes to SAA pro-inflammatory signaling in vitro and in vivo. PLoS ONE. 2017;12:e0175824 pubmed publisher |
Hum J, Clinkenbeard E, Ip C, Cass T, Allen M, White K. The metabolic bone disease associated with the Hyp mutation is independent of osteoblastic HIF1α expression. Bone Rep. 2017;6:38-43 pubmed publisher |
Po A, Silvano M, Miele E, Capalbo C, Eramo A, Salvati V, et al. Noncanonical GLI1 signaling promotes stemness features and in vivo growth in lung adenocarcinoma. Oncogene. 2017;36:4641-4652 pubmed publisher |
Yang Y, Andersson P, Hosaka K, Zhang Y, Cao R, Iwamoto H, et al. The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages. Nat Commun. 2016;7:11385 pubmed publisher |
Lee W, Kang J, Choi W, Zhang Q, Kim C, Choi U, et al. Mincle-mediated translational regulation is required for strong nitric oxide production and inflammation resolution. Nat Commun. 2016;7:11322 pubmed publisher |
Guo W, Molinaro G, Collins K, Hays S, Paylor R, Worley P, et al. Selective Disruption of Metabotropic Glutamate Receptor 5-Homer Interactions Mimics Phenotypes of Fragile X Syndrome in Mice. J Neurosci. 2016;36:2131-47 pubmed publisher |
Tuvikene J, Pruunsild P, Orav E, Esvald E, Timmusk T. AP-1 Transcription Factors Mediate BDNF-Positive Feedback Loop in Cortical Neurons. J Neurosci. 2016;36:1290-305 pubmed publisher |
Dang D, Shin E, Nam Y, Ryoo S, Jeong J, Jang C, et al. Apocynin prevents mitochondrial burdens, microglial activation, and pro-apoptosis induced by a toxic dose of methamphetamine in the striatum of mice via inhibition of p47phox activation by ERK. J Neuroinflammation. 2016;13:12 pubmed publisher |
Wang J, Li Z, Feng B, Zhang T, Zhang H, Li H, et al. Corticotrigeminal Projections from the Insular Cortex to the Trigeminal Caudal Subnucleus Regulate Orofacial Pain after Nerve Injury via Extracellular Signal-Regulated Kinase Activation in Insular Cortex Neurons. Front Cell Neurosci. 2015;9:493 pubmed publisher |
Liu Y, Zhang L, Wang C, Roy S, Shen J. Purinergic P2Y2 Receptor Control of Tissue Factor Transcription in Human Coronary Artery Endothelial Cells: NEW AP-1 TRANSCRIPTION FACTOR SITE AND NEGATIVE REGULATOR. J Biol Chem. 2016;291:1553-63 pubmed publisher |
Zhang Q, Wei L, Yang H, Yang W, Yang Q, Zhang Z, et al. Bromodomain containing protein represses the Ras/Raf/MEK/ERK pathway to attenuate human hepatoma cell proliferation during HCV infection. Cancer Lett. 2016;371:107-16 pubmed publisher |
Koerber R, Held S, Heine A, Kotthoff P, Daecke S, Bringmann A, et al. Analysis of the anti-proliferative and the pro-apoptotic efficacy of Syk inhibition in multiple myeloma. Exp Hematol Oncol. 2015;4:21 pubmed publisher |
Tang X, Basavarajappa D, Haeggström J, Wan M. P2X7 Receptor Regulates Internalization of Antimicrobial Peptide LL-37 by Human Macrophages That Promotes Intracellular Pathogen Clearance. J Immunol. 2015;195:1191-201 pubmed publisher |
Meyer K, Albaugh B, Schoenike B, Roopra A. Type 1 Insulin-Like Growth Factor Receptor/Insulin Receptor Substrate 1 Signaling Confers Pathogenic Activity on Breast Tumor Cells Lacking REST. Mol Cell Biol. 2015;35:2991-3004 pubmed publisher |
Li Y, Zhang H, Kosturakis A, Cassidy R, Zhang H, Kennamer Chapman R, et al. MAPK signaling downstream to TLR4 contributes to paclitaxel-induced peripheral neuropathy. Brain Behav Immun. 2015;49:255-66 pubmed publisher |
Sovadinova I, Babica P, Böke H, Kumar E, Wilke A, Park J, et al. Phosphatidylcholine Specific PLC-Induced Dysregulation of Gap Junctions, a Robust Cellular Response to Environmental Toxicants, and Prevention by Resveratrol in a Rat Liver Cell Model. PLoS ONE. 2015;10:e0124454 pubmed publisher |
Liu Y, Huang C, Chang C, Chou C, Lin S, Wang I, et al. Hyperphosphate-Induced Myocardial Hypertrophy through the GATA-4/NFAT-3 Signaling Pathway Is Attenuated by ERK Inhibitor Treatment. Cardiorenal Med. 2015;5:79-88 pubmed publisher |
Lourenço S, Teixeira V, Kalber T, José R, Floto R, Janes S. Macrophage migration inhibitory factor-CXCR4 is the dominant chemotactic axis in human mesenchymal stem cell recruitment to tumors. J Immunol. 2015;194:3463-74 pubmed publisher |
Briz V, Zhu G, Wang Y, Liu Y, Avetisyan M, Bi X, et al. Activity-dependent rapid local RhoA synthesis is required for hippocampal synaptic plasticity. J Neurosci. 2015;35:2269-82 pubmed publisher |
Koutsioumpa M, Poimenidi E, Pantazaka E, Theodoropoulou C, Skoura A, Megalooikonomou V, et al. Receptor protein tyrosine phosphatase beta/zeta is a functional binding partner for vascular endothelial growth factor. Mol Cancer. 2015;14:19 pubmed publisher |
Do Monte F, Quiñones Laracuente K, Quirk G. A temporal shift in the circuits mediating retrieval of fear memory. Nature. 2015;519:460-3 pubmed publisher |
Saliba Y, Karam R, Smayra V, Aftimos G, Abramowitz J, Birnbaumer L, et al. Evidence of a Role for Fibroblast Transient Receptor Potential Canonical 3 Ca2+ Channel in Renal Fibrosis. J Am Soc Nephrol. 2015;26:1855-76 pubmed publisher |
Grell A, Thigarajah R, Edvinsson L, Samraj A. Regulatory mechanism of endothelin receptor B in the cerebral arteries after focal cerebral ischemia. PLoS ONE. 2014;9:e113624 pubmed publisher |
Maury Y, Côme J, Piskorowski R, Salah Mohellibi N, Chevaleyre V, Peschanski M, et al. Combinatorial analysis of developmental cues efficiently converts human pluripotent stem cells into multiple neuronal subtypes. Nat Biotechnol. 2015;33:89-96 pubmed publisher |
Schubert M, Panja D, Haugen M, Bramham C, Vedeler C. Paraneoplastic CDR2 and CDR2L antibodies affect Purkinje cell calcium homeostasis. Acta Neuropathol. 2014;128:835-52 pubmed publisher |
Christianson J, Flyer Adams J, Drugan R, Amat J, Daut R, Foilb A, et al. Learned stressor resistance requires extracellular signal-regulated kinase in the prefrontal cortex. Front Behav Neurosci. 2014;8:348 pubmed publisher |
Gao B, Huang Q, Jie Q, Zhang H, Wang L, Guo Y, et al. Ginsenoside-Rb2 inhibits dexamethasone-induced apoptosis through promotion of GPR120 induction in bone marrow-derived mesenchymal stem cells. Stem Cells Dev. 2015;24:781-90 pubmed publisher |
Wan J, Zhao X, Vojtek A, Goldman D. Retinal injury, growth factors, and cytokines converge on β-catenin and pStat3 signaling to stimulate retina regeneration. Cell Rep. 2014;9:285-97 pubmed publisher |
Niu F, Yao H, Zhang W, Sutliff R, Buch S. Tat 101-mediated enhancement of brain pericyte migration involves platelet-derived growth factor subunit B homodimer: implications for human immunodeficiency virus-associated neurocognitive disorders. J Neurosci. 2014;34:11812-25 pubmed publisher |
Choi D, Stark D, Raphael R, Wen J, Su J, Zhou X, et al. SDF-1α stiffens myeloma bone marrow mesenchymal stromal cells through the activation of RhoA-ROCK-Myosin II. Int J Cancer. 2015;136:E219-29 pubmed publisher |
Liang J, Chao D, Sandhu H, Yu Y, Zhang L, Balboni G, et al. ?-Opioid receptors up-regulate excitatory amino acid transporters in mouse astrocytes. Br J Pharmacol. 2014;171:5417-30 pubmed publisher |
Alpár A, Tortoriello G, Calvigioni D, Niphakis M, Milenkovic I, Bakker J, et al. Endocannabinoids modulate cortical development by configuring Slit2/Robo1 signalling. Nat Commun. 2014;5:4421 pubmed publisher |
Yumnam S, Park H, Kim M, Nagappan A, Hong G, Lee H, et al. hesperidin induces paraptosis like cell death in hepatoblastoma, HepG2 Cells: involvement of ERK1/2 MAPK [corrected]. PLoS ONE. 2014;9:e101321 pubmed publisher |
Guemez Gamboa A, Xu L, Meng D, Spitzer N. Non-cell-autonomous mechanism of activity-dependent neurotransmitter switching. Neuron. 2014;82:1004-16 pubmed publisher |
Wiener Z, Band A, Kallio P, Högström J, Hyvönen V, Kaijalainen S, et al. Oncogenic mutations in intestinal adenomas regulate Bim-mediated apoptosis induced by TGF-β. Proc Natl Acad Sci U S A. 2014;111:E2229-36 pubmed publisher |
Zhao Z, Wang L, Xu W. IL-13R?2 mediates PNR-induced migration and metastasis in ER?-negative breast cancer. Oncogene. 2015;34:1596-607 pubmed publisher |
Wan M, Soehnlein O, Tang X, van der Does A, Smedler E, Uhlen P, et al. Cathelicidin LL-37 induces time-resolved release of LTB4 and TXA2 by human macrophages and triggers eicosanoid generation in vivo. FASEB J. 2014;28:3456-67 pubmed publisher |
Heckler M, Thakor H, Schafer C, Riggins R. ERK/MAPK regulates ERR? expression, transcriptional activity and receptor-mediated tamoxifen resistance in ER+ breast cancer. FEBS J. 2014;281:2431-42 pubmed publisher |
Carmon K, Gong X, Yi J, Thomas A, Liu Q. RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling. Proc Natl Acad Sci U S A. 2014;111:E1221-9 pubmed publisher |
Emery A, Eiden M, Eiden L. Separate cyclic AMP sensors for neuritogenesis, growth arrest, and survival of neuroendocrine cells. J Biol Chem. 2014;289:10126-39 pubmed publisher |
Suresh Babu S, Valdez Y, Xu A, O Byrne A, Calvo F, Lei V, et al. TGF?-mediated suppression of CD248 in non-cancer cells via canonical Smad-dependent signaling pathways is uncoupled in cancer cells. BMC Cancer. 2014;14:113 pubmed publisher |
Grzmil M, Huber R, Hess D, Frank S, Hynx D, Moncayo G, et al. MNK1 pathway activity maintains protein synthesis in rapalog-treated gliomas. J Clin Invest. 2014;124:742-54 pubmed publisher |
Lin Y, Zhang B, Liang H, Lu Y, Ai X, Zhang B, et al. JNK inhibitor SP600125 enhances TGF-?-induced apoptosis of RBE human cholangiocarcinoma cells in a Smad-dependent manner. Mol Med Rep. 2013;8:1623-9 pubmed publisher |
Voon D, Wang H, Koo J, Chai J, Hor Y, Tan T, et al. EMT-induced stemness and tumorigenicity are fueled by the EGFR/Ras pathway. PLoS ONE. 2013;8:e70427 pubmed publisher |
Nemoto W, Nakagawasai O, Yaoita F, Kanno S, Yomogida S, Ishikawa M, et al. Angiotensin II produces nociceptive behavior through spinal AT1 receptor-mediated p38 mitogen-activated protein kinase activation in mice. Mol Pain. 2013;9:38 pubmed publisher |
Osgood R, Upham B, Hill T, Helms K, Velmurugan K, Babica P, et al. Polycyclic aromatic hydrocarbon-induced signaling events relevant to inflammation and tumorigenesis in lung cells are dependent on molecular structure. PLoS ONE. 2014;8:e65150 pubmed publisher |
Korb E, Wilkinson C, Delgado R, Lovero K, Finkbeiner S. Arc in the nucleus regulates PML-dependent GluA1 transcription and homeostatic plasticity. Nat Neurosci. 2013;16:874-83 pubmed publisher |
Berdichevsky Y, Dryer A, Saponjian Y, Mahoney M, Pimentel C, Lucini C, et al. PI3K-Akt signaling activates mTOR-mediated epileptogenesis in organotypic hippocampal culture model of post-traumatic epilepsy. J Neurosci. 2013;33:9056-67 pubmed publisher |
Ito M, Zhao N, Zeng Z, Zhou X, Chang C, Zu Y. Interleukin-2 Functions in Anaplastic Large Cell Lymphoma Cells through Augmentation of Extracellular Signal-Regulated Kinases 1/2 Activation. Int J Biomed Sci. 2011;7:181-90 pubmed |
Philips G, Ye X, Kopec A, Carew T. MAPK establishes a molecular context that defines effective training patterns for long-term memory formation. J Neurosci. 2013;33:7565-73 pubmed publisher |
Melemedjian O, Khoutorsky A, Sorge R, Yan J, Asiedu M, Valdez A, et al. mTORC1 inhibition induces pain via IRS-1-dependent feedback activation of ERK. Pain. 2013;154:1080-91 pubmed publisher |
Li D, Jiao J, Shatos M, Hodges R, Dartt D. Effect of VIP on intracellular [Ca2+], extracellular regulated kinase 1/2, and secretion in cultured rat conjunctival goblet cells. Invest Ophthalmol Vis Sci. 2013;54:2872-84 pubmed publisher |
Melemedjian O, Tillu D, Asiedu M, Mandell E, Moy J, Blute V, et al. BDNF regulates atypical PKC at spinal synapses to initiate and maintain a centralized chronic pain state. Mol Pain. 2013;9:12 pubmed publisher |
Morse M, Sun H, Tran E, Levenson R, Fang Y. Label-free integrative pharmacology on-target of opioid ligands at the opioid receptor family. BMC Pharmacol Toxicol. 2013;14:17 pubmed publisher |
Yang J, Huang H, Yang H, He X, Jiang X, Shi Y, et al. Specific activation of the G protein-coupled receptor BNGR-A21 by the neuropeptide corazonin from the silkworm, Bombyx mori, dually couples to the G(q) and G(s) signaling cascades. J Biol Chem. 2013;288:11662-75 pubmed publisher |
Lucchetti C, Caligiuri I, Toffoli G, Giordano A, Rizzolio F. The prolyl isomerase Pin1 acts synergistically with CDK2 to regulate the basal activity of estrogen receptor ? in breast cancer. PLoS ONE. 2013;8:e55355 pubmed publisher |
Ahmadiantehrani S, Ron D. Dopamine D2 receptor activation leads to an up-regulation of glial cell line-derived neurotrophic factor via G??-Erk1/2-dependent induction of Zif268. J Neurochem. 2013;125:193-204 pubmed publisher |
Meyer C, Dzieran J, Liu Y, Schindler F, Munker S, Muller A, et al. Distinct dedifferentiation processes affect caveolin-1 expression in hepatocytes. Cell Commun Signal. 2013;11:6 pubmed publisher |
Jensen K, Garmaroudi F, Zhang J, Lin J, Boroomand S, Zhang M, et al. An ERK-p38 subnetwork coordinates host cell apoptosis and necrosis during coxsackievirus B3 infection. Cell Host Microbe. 2013;13:67-76 pubmed publisher |
Lowry J, Brovkovych V, Zhang Y, Skidgel R. Endothelial nitric-oxide synthase activation generates an inducible nitric-oxide synthase-like output of nitric oxide in inflamed endothelium. J Biol Chem. 2013;288:4174-93 pubmed publisher |
Ripple M, Kim N, Springett R. Acute mitochondrial inhibition by mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK) 1/2 inhibitors regulates proliferation. J Biol Chem. 2013;288:2933-40 pubmed publisher |
Lee H, Kim J, Kim E. Fucoidan from seaweed Fucus vesiculosus inhibits migration and invasion of human lung cancer cell via PI3K-Akt-mTOR pathways. PLoS ONE. 2012;7:e50624 pubmed publisher |
Ye X, Marina A, Carew T. Local synaptic integration of mitogen-activated protein kinase and protein kinase A signaling mediates intermediate-term synaptic facilitation in Aplysia. Proc Natl Acad Sci U S A. 2012;109:18162-7 pubmed publisher |
Hodges R, Bair J, Carozza R, Li D, Shatos M, Dartt D. Signaling pathways used by EGF to stimulate conjunctival goblet cell secretion. Exp Eye Res. 2012;103:99-113 pubmed publisher |
Li Y, Zhang Q, Liu Y, Luo Z, Kang L, Qu J, et al. Hepatitis C virus activates Bcl-2 and MMP-2 expression through multiple cellular signaling pathways. J Virol. 2012;86:12531-43 pubmed publisher |
Schulz M, Reisen F, Zgraggen S, Fischer S, Yuen D, Kang G, et al. Phenotype-based high-content chemical library screening identifies statins as inhibitors of in vivo lymphangiogenesis. Proc Natl Acad Sci U S A. 2012;109:E2665-74 pubmed publisher |
Chen M, Lee M, Chuang J, Li Y, Ning S, Chen J, et al. Curcumin inhibits HCV replication by induction of heme oxygenase-1 and suppression of AKT. Int J Mol Med. 2012;30:1021-8 pubmed publisher |
Moidunny S, Vinet J, Wesseling E, Bijzet J, Shieh C, Van IJzendoorn S, et al. Adenosine A2B receptor-mediated leukemia inhibitory factor release from astrocytes protects cortical neurons against excitotoxicity. J Neuroinflammation. 2012;9:198 pubmed |
Breshears L, Schlievert P, Peterson M. A disintegrin and metalloproteinase 17 (ADAM17) and epidermal growth factor receptor (EGFR) signaling drive the epithelial response to Staphylococcus aureus toxic shock syndrome toxin-1 (TSST-1). J Biol Chem. 2012;287:32578-87 pubmed |
Arora D, Köthe S, Van Den Eijnden M, Hooft van Huijsduijnen R, Heidel F, Fischer T, et al. Expression of protein-tyrosine phosphatases in Acute Myeloid Leukemia cells: FLT3 ITD sustains high levels of DUSP6 expression. Cell Commun Signal. 2012;10:19 pubmed publisher |
Sun L, Gu L, Wang S, Yuan J, Yang H, Zhu J, et al. N-acetylcysteine protects against apoptosis through modulation of group I metabotropic glutamate receptor activity. PLoS ONE. 2012;7:e32503 pubmed publisher |
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher |
Yan J, Melemedjian O, Price T, Dussor G. Sensitization of dural afferents underlies migraine-related behavior following meningeal application of interleukin-6 (IL-6). Mol Pain. 2012;8:6 pubmed publisher |
Dohgu S, Fleegal DeMotta M, Banks W. Lipopolysaccharide-enhanced transcellular transport of HIV-1 across the blood-brain barrier is mediated by luminal microvessel IL-6 and GM-CSF. J Neuroinflammation. 2011;8:167 pubmed publisher |
Zhang Q, Gong R, Qu J, Zhou Y, Liu W, Chen M, et al. Activation of the Ras/Raf/MEK pathway facilitates hepatitis C virus replication via attenuation of the interferon-JAK-STAT pathway. J Virol. 2012;86:1544-54 pubmed publisher |
Sbroggiò M, Bertero A, Velasco S, Fusella F, De Blasio E, Bahou W, et al. ERK1/2 activation in heart is controlled by melusin, focal adhesion kinase and the scaffold protein IQGAP1. J Cell Sci. 2011;124:3515-24 pubmed publisher |
Morse M, Tran E, Sun H, Levenson R, Fang Y. Ligand-directed functional selectivity at the mu opioid receptor revealed by label-free integrative pharmacology on-target. PLoS ONE. 2011;6:e25643 pubmed publisher |
Kovac A, Erickson M, Banks W. Brain microvascular pericytes are immunoactive in culture: cytokine, chemokine, nitric oxide, and LRP-1 expression in response to lipopolysaccharide. J Neuroinflammation. 2011;8:139 pubmed publisher |
Kim J, Lee J, Kim S, Choi Y, Lee W, Jeong M, et al. Thrombin-induced Migration and Matrix Metalloproteinase-9 Expression Are Regulated by MAPK and PI3K Pathways in C6 Glioma Cells. Korean J Physiol Pharmacol. 2011;15:211-6 pubmed publisher |
Gangoiti P, Bernacchioni C, Donati C, Cencetti F, Ouro A, Gomez Munoz A, et al. Ceramide 1-phosphate stimulates proliferation of C2C12 myoblasts. Biochimie. 2012;94:597-607 pubmed publisher |
Melemedjian O, Asiedu M, Tillu D, Sanoja R, Yan J, Lark A, et al. Targeting adenosine monophosphate-activated protein kinase (AMPK) in preclinical models reveals a potential mechanism for the treatment of neuropathic pain. Mol Pain. 2011;7:70 pubmed publisher |
Hsu H, Hu W, Lin Y, Kuo W, Chen L, Chen W, et al. JNK suppression is essential for 17?-Estradiol inhibits prostaglandin E2-Induced uPA and MMP-9 expressions and cell migration in human LoVo colon cancer cells. J Biomed Sci. 2011;18:61 pubmed publisher |
Roselli F, Livrea P, Almeida O. CDK5 is essential for soluble amyloid ?-induced degradation of GKAP and remodeling of the synaptic actin cytoskeleton. PLoS ONE. 2011;6:e23097 pubmed publisher |
Makhortova N, Hayhurst M, Cerqueira A, Sinor Anderson A, Zhao W, Heiser P, et al. A screen for regulators of survival of motor neuron protein levels. Nat Chem Biol. 2011;7:544-52 pubmed publisher |
Rubert J, Qian Z, Andraos R, Guthy D, Radimerski T. Bim and Mcl-1 exert key roles in regulating JAK2V617F cell survival. BMC Cancer. 2011;11:24 pubmed publisher |
Zhao W, Chuang S, Bianchi R, Wong R. Dual regulation of fragile X mental retardation protein by group I metabotropic glutamate receptors controls translation-dependent epileptogenesis in the hippocampus. J Neurosci. 2011;31:725-34 pubmed publisher |
Mou L, Heldt S, Ressler K. Rapid brain-derived neurotrophic factor-dependent sequestration of amygdala and hippocampal GABA(A) receptors via different tyrosine receptor kinase B-mediated phosphorylation pathways. Neuroscience. 2011;176:72-85 pubmed publisher |
Meitzen J, Luoma J, Stern C, Mermelstein P. ?1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons. J Neurochem. 2011;116:984-95 pubmed publisher |
Melemedjian O, Asiedu M, Tillu D, Peebles K, Yan J, Ertz N, et al. IL-6- and NGF-induced rapid control of protein synthesis and nociceptive plasticity via convergent signaling to the eIF4F complex. J Neurosci. 2010;30:15113-23 pubmed publisher |
Beshir A, Ren G, Magpusao A, Barone L, Yeung K, Fenteany G. Raf kinase inhibitor protein suppresses nuclear factor-?B-dependent cancer cell invasion through negative regulation of matrix metalloproteinase expression. Cancer Lett. 2010;299:137-49 pubmed publisher |
Chen W, Liu I, Chang Y, Chen Y, Chen C, Yen C, et al. Ca(v)3.2 T-type Ca2+ channel-dependent activation of ERK in paraventricular thalamus modulates acid-induced chronic muscle pain. J Neurosci. 2010;30:10360-8 pubmed publisher |
Kolber B, Montana M, Carrasquillo Y, Xu J, Heinemann S, Muglia L, et al. Activation of metabotropic glutamate receptor 5 in the amygdala modulates pain-like behavior. J Neurosci. 2010;30:8203-13 pubmed publisher |
Le M, Chan J, Rosenberg S, Nabatian A, Merrigan K, Cohen Solal K, et al. The glutamate release inhibitor Riluzole decreases migration, invasion, and proliferation of melanoma cells. J Invest Dermatol. 2010;130:2240-9 pubmed publisher |
Braun O, Lu D, Aroonsakool N, Insel P. Uridine triphosphate (UTP) induces profibrotic responses in cardiac fibroblasts by activation of P2Y2 receptors. J Mol Cell Cardiol. 2010;49:362-9 pubmed publisher |
Ito M, Zhao N, Zeng Z, Chang C, Zu Y. Synergistic growth inhibition of anaplastic large cell lymphoma cells by combining cellular ALK gene silencing and a low dose of the kinase inhibitor U0126. Cancer Gene Ther. 2010;17:633-44 pubmed publisher |
Pera T, Gosens R, Lesterhuis A, Sami R, van der Toorn M, Zaagsma J, et al. Cigarette smoke and lipopolysaccharide induce a proliferative airway smooth muscle phenotype. Respir Res. 2010;11:48 pubmed publisher |
Huang Y, Yang C, Huang C, Tai M, Hsu K. Pharmacological and genetic accumulation of hypoxia-inducible factor-1alpha enhances excitatory synaptic transmission in hippocampal neurons through the production of vascular endothelial growth factor. J Neurosci. 2010;30:6080-93 pubmed publisher |
He K, Aizenman E. ERK signaling leads to mitochondrial dysfunction in extracellular zinc-induced neurotoxicity. J Neurochem. 2010;114:452-61 pubmed publisher |
Chotiner J, Nielson J, Farris S, Lewandowski G, Huang F, Banos K, et al. Assessment of the role of MAP kinase in mediating activity-dependent transcriptional activation of the immediate early gene Arc/Arg3.1 in the dentate gyrus in vivo. Learn Mem. 2010;17:117-29 pubmed publisher |
Ishida T, Nakajima T, Kudo A, Kawakami A. Phosphorylation of Junb family proteins by the Jun N-terminal kinase supports tissue regeneration in zebrafish. Dev Biol. 2010;340:468-79 pubmed publisher |
Riedl M, Braun P, Kitto K, ROIKO S, Anderson L, Honda C, et al. Proteomic analysis uncovers novel actions of the neurosecretory protein VGF in nociceptive processing. J Neurosci. 2009;29:13377-88 pubmed publisher |
Roscioni S, Kistemaker L, Menzen M, Elzinga C, Gosens R, Halayko A, et al. PKA and Epac cooperate to augment bradykinin-induced interleukin-8 release from human airway smooth muscle cells. Respir Res. 2009;10:88 pubmed publisher |
Doulatov S, Notta F, Rice K, Howell L, Zelent A, Licht J, et al. PLZF is a regulator of homeostatic and cytokine-induced myeloid development. Genes Dev. 2009;23:2076-87 pubmed publisher |
Zhong J, Chuang S, Bianchi R, Zhao W, Lee H, Fenton A, et al. BC1 regulation of metabotropic glutamate receptor-mediated neuronal excitability. J Neurosci. 2009;29:9977-86 pubmed publisher |
Huang C, Hsu K. Activation of muscarinic acetylcholine receptors induces a nitric oxide-dependent long-term depression in rat medial prefrontal cortex. Cereb Cortex. 2010;20:982-96 pubmed publisher |
Roselli F, Hutzler P, Wegerich Y, Livrea P, Almeida O. Disassembly of shank and homer synaptic clusters is driven by soluble beta-amyloid(1-40) through divergent NMDAR-dependent signalling pathways. PLoS ONE. 2009;4:e6011 pubmed publisher |
Magliaro B, Saldanha C. Clozapine protects PC-12 cells from death due to oxidative stress induced by hydrogen peroxide via a cell-type specific mechanism involving inhibition of extracellular signal-regulated kinase phosphorylation. Brain Res. 2009;1283:14-24 pubmed publisher |
Upham B, Park J, Babica P, Sovadinova I, Rummel A, Trosko J, et al. Structure-activity-dependent regulation of cell communication by perfluorinated fatty acids using in vivo and in vitro model systems. Environ Health Perspect. 2009;117:545-51 pubmed publisher |
Tsuda M, Toyomitsu E, Kometani M, Tozaki Saitoh H, Inoue K. Mechanisms underlying fibronectin-induced up-regulation of P2X4R expression in microglia: distinct roles of PI3K-Akt and MEK-ERK signalling pathways. J Cell Mol Med. 2009;13:3251-9 pubmed publisher |
Park S, Na H, Kim E, Cha Y, Surh Y. 4-hydroxyestradiol induces anchorage-independent growth of human mammary epithelial cells via activation of IkappaB kinase: potential role of reactive oxygen species. Cancer Res. 2009;69:2416-24 pubmed publisher |
Pintchovski S, Peebles C, Kim H, Verdin E, Finkbeiner S. The serum response factor and a putative novel transcription factor regulate expression of the immediate-early gene Arc/Arg3.1 in neurons. J Neurosci. 2009;29:1525-37 pubmed publisher |
Coba M, Valor L, Kopanitsa M, Afinowi N, Grant S. Kinase networks integrate profiles of N-methyl-D-aspartate receptor-mediated gene expression in hippocampus. J Biol Chem. 2008;283:34101-7 pubmed publisher |
Lim S, Davidson S, Paramanathan A, Smith C, Yellon D, Hausenloy D. The novel adipocytokine visfatin exerts direct cardioprotective effects. J Cell Mol Med. 2008;12:1395-403 pubmed publisher |
Dohgu S, Banks W. Lipopolysaccharide-enhanced transcellular transport of HIV-1 across the blood-brain barrier is mediated by the p38 mitogen-activated protein kinase pathway. Exp Neurol. 2008;210:740-9 pubmed publisher |
Huang F, Chotiner J, Steward O. Actin polymerization and ERK phosphorylation are required for Arc/Arg3.1 mRNA targeting to activated synaptic sites on dendrites. J Neurosci. 2007;27:9054-67 pubmed |
Khan A, Ponzio T, Sanchez Watts G, Stanley B, Hatton G, Watts A. Catecholaminergic control of mitogen-activated protein kinase signaling in paraventricular neuroendocrine neurons in vivo and in vitro: a proposed role during glycemic challenges. J Neurosci. 2007;27:7344-60 pubmed |
Liu H, Enyeart J, Enyeart J. Angiotensin II inhibits native bTREK-1 K+ channels through a PLC-, kinase C-, and PIP2-independent pathway requiring ATP hydrolysis. Am J Physiol Cell Physiol. 2007;293:C682-95 pubmed |
Schaafsma D, Gosens R, Ris J, Zaagsma J, Meurs H, Nelemans S. Insulin induces airway smooth muscle contraction. Br J Pharmacol. 2007;150:136-42 pubmed |
Alao J, Stavropoulou A, Lam E, Coombes R. Role of glycogen synthase kinase 3 beta (GSK3beta) in mediating the cytotoxic effects of the histone deacetylase inhibitor trichostatin A (TSA) in MCF-7 breast cancer cells. Mol Cancer. 2006;5:40 pubmed |
O Riordan K, Huang I, Pizzi M, Spano P, Boroni F, Egli R, et al. Regulation of nuclear factor kappaB in the hippocampus by group I metabotropic glutamate receptors. J Neurosci. 2006;26:4870-9 pubmed |
Kauppinen T, Chan W, Suh S, Wiggins A, Huang E, Swanson R. Direct phosphorylation and regulation of poly(ADP-ribose) polymerase-1 by extracellular signal-regulated kinases 1/2. Proc Natl Acad Sci U S A. 2006;103:7136-41 pubmed |
Bellik L, Vinci M, Filippi S, Ledda F, Parenti A. Intracellular pathways triggered by the selective FLT-1-agonist placental growth factor in vascular smooth muscle cells exposed to hypoxia. Br J Pharmacol. 2005;146:568-75 pubmed |
Pierre S, Häusler J, Birod K, Geisslinger G, Scholich K. PAM mediates sustained inhibition of cAMP signaling by sphingosine-1-phosphate. EMBO J. 2004;23:3031-40 pubmed |
Gallagher S, Daly C, Bear M, Huber K. Extracellular signal-regulated protein kinase activation is required for metabotropic glutamate receptor-dependent long-term depression in hippocampal area CA1. J Neurosci. 2004;24:4859-64 pubmed |
Wang Q, Walsh D, Rowan M, Selkoe D, Anwyl R. Block of long-term potentiation by naturally secreted and synthetic amyloid beta-peptide in hippocampal slices is mediated via activation of the kinases c-Jun N-terminal kinase, cyclin-dependent kinase 5, and p38 mitogen-activated protein kinase as w. J Neurosci. 2004;24:3370-8 pubmed |
Dominguez R, Jalali C, De Lacalle S. Morphological effects of estrogen on cholinergic neurons in vitro involves activation of extracellular signal-regulated kinases. J Neurosci. 2004;24:982-90 pubmed |
Atherton H, Jones G, Danahay H. IL-13-induced changes in the goblet cell density of human bronchial epithelial cell cultures: MAP kinase and phosphatidylinositol 3-kinase regulation. Am J Physiol Lung Cell Mol Physiol. 2003;285:L730-9 pubmed |
Roberts R. Role of the extracellular signal-regulated kinase (Erk) signal transduction cascade in alpha(2) adrenoceptor-mediated vasoconstriction in porcine palmar lateral vein. Br J Pharmacol. 2001;133:859-66 pubmed |
