1141/10 | Tocris Bioscience 1141/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

1141/10

catalog :

1141/10

quantity :

10 mg (also 50 mg)

price :

127 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Sarkar A, Mei A, Paquola A, Stern S, Bardy C, Klug J, et al. Efficient Generation of CA3 Neurons from Human Pluripotent Stem Cells Enables Modeling of Hippocampal Connectivity In Vitro. Cell Stem Cell. 2018;22:684-697.e9 pubmed publisher
Belgacem Y, Borodinsky L. Inversion of Sonic hedgehog action on its canonical pathway by electrical activity. Proc Natl Acad Sci U S A. 2015;112:4140-5 pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Kelm M, Criswell H, Breese G. The role of protein kinase A in the ethanol-induced increase in spontaneous GABA release onto cerebellar Purkinje neurons. J Neurophysiol. 2008;100:3417-28 pubmed publisher
Park W, Han J, Kim N, Ko J, Kim S, Earm Y. Activation of inward rectifier K+ channels by hypoxia in rabbit coronary arterial smooth muscle cells. Am J Physiol Heart Circ Physiol. 2005;289:H2461-7 pubmed

product information

master code :

1141

SKU :

1141/10

product name :

Dibutyryl-cAMP, sodium salt

unit size :

10 mg (also 50 mg)

description :

Cell-permeable cAMP analog

target :

cAMP Compounds

category :

Small Molecules

purity :

98%

observed molecular weight :

491.37

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Dibutyryl-cAMP sodium salt is a cell-permeable analog of cAMP that activates cAMP-dependent protein kinases and is a phosphodiesterase inhibitor. Combined with other reagents, dibutyryl-cAMP promotes differentiation of neural stem/progenitor cells (NSPCs) and other cell lines and increases survival rates of NSPCs and differentiation into neurons in vivo . Promotes neurite outgrowth in cell cultures. Dibutyryl-cAMP has anti-inflammatory activity and is used to promote wound healing. Choline acetyltransferase and vesicular acetylcholine transporter mRNA are increased in cells treated with dibutyryl-cAMP.

top caption :

Cell-permeable cAMP analog

extended description :

Cell-permeable cAMP analog

chemical name text :

N6,O2 -Dibutyryl adenosine 3 ,5 -cyclic monophosphate sodium salt

formula :

C18H23N5NaO8P

formula text :

C18H23N5NaO8P

cas num :

16980-89-5

USD :

127 USD

product details :

Cell-permeable cAMP analog

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage