1140/10 | Tocris Bioscience 1140/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

1140/10

catalog :

1140/10

quantity :

10 mg (also 50 mg)

price :

87 USD

more info or order :

Tocris Bioscience product webpage

citations: 15

Reference
Cruz J, Hupper N, Wilson L, Concannon J, Wang Y, Oberhauser B, et al. Protein kinase A activation inhibits DUX4 gene expression in myotubes from patients with facioscapulohumeral muscular dystrophy. J Biol Chem. 2018;293:11837-11849 pubmed publisher
Dorrello N, Guenthart B, O Neill J, Kim J, Cunningham K, Chen Y, et al. Functional vascularized lung grafts for lung bioengineering. Sci Adv. 2017;3:e1700521 pubmed publisher
Tuesta L, Chen Z, Duncan A, Fowler C, Ishikawa M, Lee B, et al. GLP-1 acts on habenular avoidance circuits to control nicotine intake. Nat Neurosci. 2017;20:708-716 pubmed publisher
Tozzi A, de Iure A, Tantucci M, Durante V, Quiroga Varela A, GiampÃ C, et al. Endogenous 17Î²-estradiol is required for activity-dependent long-term potentiation in the striatum: interaction with the dopaminergic system. Front Cell Neurosci. 2015;9:192 pubmed publisher
Ferrari L, Araldi D, Levine J. Distinct terminal and cell body mechanisms in the nociceptor mediate hyperalgesic priming. J Neurosci. 2015;35:6107-16 pubmed publisher
Wang J, Lee Y, Chou M, Chang R, Chiu C, Liang Y, et al. Astaxanthin protects steroidogenesis from hydrogen peroxide-induced oxidative stress in mouse Leydig cells. Mar Drugs. 2015;13:1375-88 pubmed publisher
Meena A, Tovey S, Taylor C. Sustained signalling by PTH modulates IP3 accumulation and IP3 receptors through cyclic AMP junctions. J Cell Sci. 2015;128:408-20 pubmed publisher
Adelfinger L, Turecek R, Ivankova K, Jensen A, Moss S, Gassmann M, et al. GABAB receptor phosphorylation regulates KCTD12-induced K? current desensitization. Biochem Pharmacol. 2014;91:369-79 pubmed publisher
Niedenberger B, Chappell V, Otey C, Geyer C. Actin dynamics regulate subcellular localization of the F-actin-binding protein PALLD in mouse Sertoli cells. Reproduction. 2014;148:333-41 pubmed publisher
Blasic J, Brown R, Robinson P. Phosphorylation of mouse melanopsin by protein kinase A. PLoS ONE. 2012;7:e45387 pubmed publisher
Ylostalo J, Bartosh T, Coble K, Prockop D. Human mesenchymal stem/stromal cells cultured as spheroids are self-activated to produce prostaglandin E2 that directs stimulated macrophages into an anti-inflammatory phenotype. Stem Cells. 2012;30:2283-96 pubmed publisher
Nakao T, Tsujikawa M, Notomi S, Ikeda Y, Nishida K. The role of mislocalized phototransduction in photoreceptor cell death of retinitis pigmentosa. PLoS ONE. 2012;7:e32472 pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Goffin D, Ali A, Rampersaud N, Harkavyi A, Fuchs C, Whitton P, et al. Dopamine-dependent tuning of striatal inhibitory synaptogenesis. J Neurosci. 2010;30:2935-50 pubmed publisher
Sergeant G, Craven M, Hollywood M, McHale N, Thornbury K. Spontaneous Ca2+ waves in rabbit corpus cavernosum: modulation by nitric oxide and cGMP. J Sex Med. 2009;6:958-966 pubmed publisher

product information

master code :

1140

SKU :

1140/10

product name :

8-Bromo-cAMP, sodium salt

unit size :

10 mg (also 50 mg)

description :

Cell-permeable cAMP analog

target :

cAMP Compounds

category :

Small Molecules

purity :

99%

observed molecular weight :

430.09

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

8-Bromo-cAMP, sodium salt is a cell-permeable cyclic AMP (cAMP) analog. It activates PKA and has greater resistance to hydrolysis by phosphodiesterase (PDE) than cAMP. It increases differentiation and induces apoptosis in an esophageal cancer cell line. 8-Bromo-cAMP enhances the induction of pluripotency in human fibroblast cells in combination with VPA (valproic acid) (Cat. No. 2815). In combination with IBMX (Cat. No. 2845), it promotes the differentiation of human iPS cell-derived intestinal epithelial cells. It induces cell-based VEGF production for angiogenesis and osteoblastic differentiation in vitro .

top caption :

Cell-permeable cAMP analog

extended description :

Cell-permeable cAMP analog

chemical name text :

8-Bromoadenosine-3 ,5 -cyclic monophosphate sodium salt

formula :

C10H10BrN5NaO6P

formula text :

C10H10BrN5NaO6P

cas num :

76939-46-3

USD :

87 USD

product details :

Cell-permeable cAMP analog

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage