product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
1136/100U
catalog :
1136/100U
quantity :
100 ug
price :
343 USD
more info or order :
citations: 29
Reference
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Coates C, Lim J, Harman K, Rowley A, Griffiths D, Emery H, et al. The insect, Galleria mellonella, is a compatible model for evaluating the toxicology of okadaic acid. Cell Biol Toxicol. 2019;35:219-232 pubmed publisher
Jones D, Jenney A, Joughin B, Sorger P, Lauffenburger D. Inflammatory but not mitogenic contexts prime synovial fibroblasts for compensatory signaling responses to p38 inhibition. Sci Signal. 2018;11: pubmed publisher
Pose Utrilla J, Garcia Guerra L, del Puerto A, Martin A, Jurado Arjona J, De León Reyes N, et al. Excitotoxic inactivation of constitutive oxidative stress detoxification pathway in neurons can be rescued by PKD1. Nat Commun. 2017;8:2275 pubmed publisher
Guillaud L, Dimitrov D, Takahashi T. Presynaptic morphology and vesicular composition determine vesicle dynamics in mouse central synapses. elife. 2017;6: pubmed publisher
Bartley C, O Keefe R, Blice Baum A, Mihailescu M, Gong X, Miyares L, et al. Mammalian FMRP S499 Is Phosphorylated by CK2 and Promotes Secondary Phosphorylation of FMRP. Eneuro. 2016;3: pubmed
Kii I, Sumida Y, Goto T, Sonamoto R, Okuno Y, Yoshida S, et al. Selective inhibition of the kinase DYRK1A by targeting its folding process. Nat Commun. 2016;7:11391 pubmed publisher
Polito M, Guiot E, Gangarossa G, Longueville S, Doulazmi M, Valjent E, et al. Selective Effects of PDE10A Inhibitors on Striatopallidal Neurons Require Phosphatase Inhibition by DARPP-32(1,2,3). Eneuro. 2015;2: pubmed publisher
Hullinger R, O Riordan K, Burger C. Environmental enrichment improves learning and memory and long-term potentiation in young adult rats through a mechanism requiring mGluR5 signaling and sustained activation of p70s6k. Neurobiol Learn Mem. 2015;125:126-34 pubmed publisher
Cohen S, Li B, Tsien R, Ma H. Evolutionary and functional perspectives on signaling from neuronal surface to nucleus. Biochem Biophys Res Commun. 2015;460:88-99 pubmed publisher
Martin B, Wang C, Willette Brown J, Herjan T, Gulen M, Zhou H, et al. IKK? negatively regulates ASC-dependent inflammasome activation. Nat Commun. 2014;5:4977 pubmed publisher
Chen Z, Xiong C, Pancyr C, Stockwell J, Walz W, Cayabyab F. Prolonged adenosine A1 receptor activation in hypoxia and pial vessel disruption focal cortical ischemia facilitates clathrin-mediated AMPA receptor endocytosis and long-lasting synaptic inhibition in rat hippocampal CA3-CA1 synapses: differential re. J Neurosci. 2014;34:9621-43 pubmed publisher
Pribiag H, Stellwagen D. TNF-? downregulates inhibitory neurotransmission through protein phosphatase 1-dependent trafficking of GABA(A) receptors. J Neurosci. 2013;33:15879-93 pubmed publisher
Bernard P, Castano A, O Leary H, Simpson K, Browning M, Benke T. Phosphorylation of FMRP and alterations of FMRP complex underlie enhanced mLTD in adult rats triggered by early life seizures. Neurobiol Dis. 2013;59:1-17 pubmed publisher
Seto S, Au A, Poon C, Zhang Q, Li R, Yeung J, et al. Acute simvastatin inhibits K ATP channels of porcine coronary artery myocytes. PLoS ONE. 2013;8:e66404 pubmed publisher
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Dart C, Leyland M. Targeting of an A kinase-anchoring protein, AKAP79, to an inwardly rectifying potassium channel, Kir2.1. J Biol Chem. 2001;276:20499-505 pubmed
image
image 1 :
Tocris Bioscience 1136/100U image 1
Protein phosphatase 1 and 2A inhibitor
product information
master code :
1136
SKU :
1136/100U
product name :
Okadaic acid
unit size :
100 ug
description :
Protein phosphatase 1 and 2A inhibitor
target :
Protein Ser/Thr Phosphatase Inhibitors
category :
Small Molecules
purity :
90%
observed molecular weight :
805.01
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Okadaic acid is a potent inhibitor of protein phosphatase 1 (IC50 = 3 nM) and protein phosphatase 2A (IC50 = 0.2-1 nM). Displays 100,000,000-fold selectivity over PP2B and PP2C. Tumor promoter. Shown to activate atypical protein kinase C in adipocytes.
top caption :
Protein phosphatase 1 and 2A inhibitor
extended description :
Protein phosphatase 1 and 2A inhibitor
chemical name text :
9,10-Deepithio-9,10-didehydroacanthifolicin
formula :
C44H68O13
formula text :
C44H68O13
cas num :
78111-17-8
USD :
343 USD
product details :
Protein phosphatase 1 and 2A inhibitor
storage :
Store at -20░C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK