product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
1134/10
catalog :
1134/10
quantity :
10 mg (also 50 mg)
price :
108 USD
more info or order :
citations: 7
Reference
Kilpatrick L, Alcobia D, White C, Peach C, Glenn J, Zimmerman K, et al. Complex Formation between VEGFR2 and the β2-Adrenoceptor. Cell Chem Biol. 2019;26:830-841.e9 pubmed publisher
Littmann T, Göttle M, Reinartz M, Kälble S, Wainer I, Ozawa T, et al. Recruitment of β-arrestin 1 and 2 to the β2-adrenoceptor: analysis of 65 ligands. J Pharmacol Exp Ther. 2015;355:183-90 pubmed publisher
Stoddart L, Johnstone E, Wheal A, Goulding J, Robers M, Machleidt T, et al. Application of BRET to monitor ligand binding to GPCRs. Nat Methods. 2015;12:661-663 pubmed publisher
Gherbi K, May L, Baker J, Briddon S, Hill S. Negative cooperativity across β1-adrenoceptor homodimers provides insights into the nature of the secondary low-affinity CGP 12177 β1-adrenoceptor binding conformation. FASEB J. 2015;29:2859-71 pubmed publisher
Gherbi K, Briddon S, Hill S. Detection of the secondary, low-affinity ?1 -adrenoceptor site in living cells using the fluorescent CGP 12177 derivative BODIPY-TMR-CGP. Br J Pharmacol. 2014;171:5431-45 pubmed publisher
Suarez J, Rivera P, Arrabal S, Crespillo A, Serrano A, Baixeras E, et al. Oleoylethanolamide enhances β-adrenergic-mediated thermogenesis and white-to-brown adipocyte phenotype in epididymal white adipose tissue in rat. Dis Model Mech. 2014;7:129-41 pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
product information
master code :
1134
SKU :
1134/10
product name :
CGP 12177 hydrochloride
unit size :
10 mg (also 50 mg)
description :
3 partial agonist. 1/ 2 antagonist
target :
Adrenergic beta-3 Receptor Agonists
category :
Small Molecules
observed molecular weight :
315.8
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
CGP 12177 hydrochloride is a partial agonist at 3-adrenoceptors. 1- and 2-adrenoceptor antagonist (Ki values are 0.9, 4 and 88 nM for 1, 2 and 3 receptors respectively).
top caption :
3 partial agonist. 1/ 2 antagonist
extended description :
3 partial agonist. 1/ 2 antagonist
chemical name text :
4-[3-[(1,1-Dimethylethyl)amino]2-hydroxypropoxy]-1,3-dihydro-2H-benzimidazol-2-one hydrochloride
formula :
C14H21N3O3.HCl
formula text :
C14H21N3O3.HCl
cas num :
64208-32-8
USD :
108 USD
product details :
3 partial agonist. 1/ 2 antagonist
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK