BRL 54443 | Tocris Bioscience 1129 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

BRL 54443

catalog :

1129

quantity :

10 mg (also 50 mg)

price :

118 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Klein M, Dukat M, Glennon R, Teitler M. Toward selective drug development for the human 5-hydroxytryptamine 1E receptor: a comparison of 5-hydroxytryptamine 1E and 1F receptor structure-affinity relationships. J Pharmacol Exp Ther. 2011;337:860-7 pubmed publisher
Müller T, Dürk T, Blumenthal B, Grimm M, Cicko S, Panther E, et al. 5-hydroxytryptamine modulates migration, cytokine and chemokine release and T-cell priming capacity of dendritic cells in vitro and in vivo. PLoS ONE. 2009;4:e6453 pubmed publisher

product information

brand :

Tocris

master code :

1129

SKU :

1129/10

product name :

BRL 54443

description :

Potent 5-ht1E and 5-HT1F agonist

target :

5-HT1E Receptor Agonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

observed molecular weight :

230.31

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

A potent 5-ht1E/1F receptor agonist (pEC50 values are 8.5 and 8.6 respectively). Displays 30-fold selectivity over other 5-HT and dopamine receptors (pKi values are 8.7. 8.9, 7.2, 6.9, 7.2, 5.9, 7.0, 6.5, 6, 6, 6.3 and 6.2 for human 5-HT1E, 1F, 1A, 1B, 1D, 2A, 2B, 2C, 4, 7, D2 and D3 receptors respectively). Induces 5-HT2A receptor-mediated mouse aortic contraction in vitro (pEC50 = 6.52). Active in vivo .

catalog number base :

1129

product keywords :

Potent 5-ht1E/F agonists Serotonin 5-HT1F Receptors 5-HT1E BRL54443 5-ht1E Receptors 5-HT1F Receptors 1129,

extended description :

Potent 5-ht1E and 5-HT1F agonist

chemical name text :

5-Hydroxy-3-(1-methylpiperidin-4-yl)-1H-indole

formula :

C 14 H 18 N 2 O

formula text :

C14H18N2O

cas num :

57477-39-1

2020 USD :

118

2021 USD :

118 USD

storage :

Desiccate at +4°C

more info or order :

Tocris Bioscience product webpage