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company name :
Tocris Bioscience
product type :
chemical
product name :
1127/1G
catalog :
1127/1G
quantity :
1 g
price :
78 USD
more info or order :
citations: 22
Reference
Hirschberg S, Li Y, Randall A, Kremer E, Pickering A. Functional dichotomy in spinal- vs prefrontal-projecting locus coeruleus modules splits descending noradrenergic analgesia from ascending aversion and anxiety in rats. elife. 2017;6: pubmed publisher
Kastman H, Blasiak A, Walker L, Siwiec M, Krstew E, Gundlach A, et al. Nucleus incertus Orexin2 receptors mediate alcohol seeking in rats. Neuropharmacology. 2016;110:82-91 pubmed publisher
Delaney A, Crane J. Presynaptic GABAB receptors reduce transmission at parabrachial synapses in the lateral central amygdala by inhibiting N-type calcium channels. Sci Rep. 2016;6:19255 pubmed publisher
Scardochio T, Trujillo Pisanty I, Conover K, Shizgal P, Clarke P. The Effects of Electrical and Optical Stimulation of Midbrain Dopaminergic Neurons on Rat 50-kHz Ultrasonic Vocalizations. Front Behav Neurosci. 2015;9:331 pubmed publisher
Dudek M, Knutelska J, Bednarski M, Nowiński L, Zygmunt M, Mordyl B, et al. A Comparison of the Anorectic Effect and Safety of the Alpha2-Adrenoceptor Ligands Guanfacine and Yohimbine in Rats with Diet-Induced Obesity. PLoS ONE. 2015;10:e0141327 pubmed publisher
Phelps C, Mitchell E, Nutt D, Marston H, Robinson E. Psychopharmacological characterisation of the successive negative contrast effect in rats. Psychopharmacology (Berl). 2015;232:2697-709 pubmed publisher
Soty M, Penhoat A, Amigó Correig M, Vinera J, Sardella A, Vullin Bouilloux F, et al. A gut-brain neural circuit controlled by intestinal gluconeogenesis is crucial in metabolic health. Mol Metab. 2015;4:106-17 pubmed publisher
Gazarini L, Stern C, Piornedo R, Takahashi R, Bertoglio L. PTSD-like memory generated through enhanced noradrenergic activity is mitigated by a dual step pharmacological intervention targeting its reconsolidation. Int J Neuropsychopharmacol. 2014;18: pubmed publisher
Yuen E, Qin L, Wei J, Liu W, Liu A, Yan Z. Synergistic regulation of glutamatergic transmission by serotonin and norepinephrine reuptake inhibitors in prefrontal cortical neurons. J Biol Chem. 2014;289:25177-85 pubmed publisher
Drake R, Hulse R, Lumb B, Donaldson L. The degree of acute descending control of spinal nociception in an area of primary hyperalgesia is dependent on the peripheral domain of afferent input. J Physiol. 2014;592:3611-24 pubmed publisher
Ciccocioppo R, Stopponi S, Economidou D, Kuriyama M, Kinoshita H, Heilig M, et al. Chronic treatment with novel brain-penetrating selective NOP receptor agonist MT-7716 reduces alcohol drinking and seeking in the rat. Neuropsychopharmacology. 2014;39:2601-10 pubmed publisher
Costello M, Reynaga D, Mojica C, Zaveri N, Belluzzi J, Leslie F. Comparison of the reinforcing properties of nicotine and cigarette smoke extract in rats. Neuropsychopharmacology. 2014;39:1843-51 pubmed publisher
Corcoran A, Commons K, Wu Y, Smith J, Harris M, Richerson G. Dual effects of 5-HT(1a) receptor activation on breathing in neonatal mice. J Neurosci. 2014;34:51-9 pubmed publisher
Ryan P, Kastman H, Krstew E, Rosengren K, Hossain M, Churilov L, et al. Relaxin-3/RXFP3 system regulates alcohol-seeking. Proc Natl Acad Sci U S A. 2013;110:20789-94 pubmed publisher
Gozzi A, Lepore S, Vicentini E, Merlo Pich E, Bifone A. Differential effect of orexin-1 and CRF-1 antagonism on stress circuits: a fMRI study in the rat with the pharmacological stressor Yohimbine. Neuropsychopharmacology. 2013;38:2120-30 pubmed publisher
Mondal A, Aizawa S, Sakata I, Goswami C, Oda S, Sakai T. Mechanism of ghrelin-induced gastric contractions in Suncus murinus (house musk shrew): involvement of intrinsic primary afferent neurons. PLoS ONE. 2013;8:e60365 pubmed publisher
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Marchese G, Casti P, Ruiu S, Saba P, Sanna A, Casu G, et al. Haloperidol, but not clozapine, produces dramatic catalepsy in delta9-THC-treated rats: possible clinical implications. Br J Pharmacol. 2003;140:520-6 pubmed
product information
master code :
1127
SKU :
1127/1G
product name :
Yohimbine hydrochloride
unit size :
1 g
description :
Selective 2 antagonist
target :
Adrenergic alpha-2 Receptor Antagonists
category :
Small Molecules
purity :
98%
observed molecular weight :
390.91
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Yohimbine hydrochloride is a 2-adrenoceptor antagonist (pKi values are 8.52, 8.00 and 9.17 for human 2A, 2B and 2C receptors respectively). . Diastereomer also available.
top caption :
Selective 2 antagonist
extended description :
Selective 2 antagonist
chemical name text :
17 -Hydroxyyohimban-16 -carboxylic acid methyl ester hydrochloride
formula :
C21H26N2O3.HCl
formula text :
C21H26N2O3.HCl
cas num :
65-19-0
USD :
78 USD
product details :
Selective 2 antagonist
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK