Dexamethasone | Tocris Bioscience 1126 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Dexamethasone

catalog :

1126

quantity :

100 mg

price :

88 USD

more info or order :

Tocris Bioscience product webpage

citations: 9

Reference
Segal J, Kent D, Wesche D, Ng S, Serra M, Oulès B, et al. Single cell analysis of human foetal liver captures the transcriptional profile of hepatobiliary hybrid progenitors. Nat Commun. 2019;10:3350 pubmed publisher
Ibrahim S, Xie W, Strong J, Tonello R, Berta T, Zhang J. Mineralocorticoid Antagonist Improves Glucocorticoid Receptor Signaling and Dexamethasone Analgesia in an Animal Model of Low Back Pain. Front Cell Neurosci. 2018;12:453 pubmed publisher
Peng W, Logan C, Fish M, Anbarchian T, Aguisanda F, Álvarez Varela A, et al. Inflammatory Cytokine TNFα Promotes the Long-Term Expansion of Primary Hepatocytes in 3D Culture. Cell. 2018;175:1607-1619.e15 pubmed publisher
Sampaziotis F, de Brito M, Geti I, Bertero A, Hannan N, Vallier L. Directed differentiation of human induced pluripotent stem cells into functional cholangiocyte-like cells. Nat Protoc. 2017;12:814-827 pubmed publisher
Pinheiro B, Lemos C, Neutzling Kaufmann F, Marques J, da Silva Santos C, Carvalho E, et al. Hierarchical glucocorticoid-endocannabinoid interplay regulates the activation of the nucleus accumbens by insulin. Brain Res Bull. 2016;124:222-30 pubmed publisher
Huch M, Gehart H, van Boxtel R, Hamer K, Blokzijl F, Verstegen M, et al. Long-term culture of genome-stable bipotent stem cells from adult human liver. Cell. 2015;160:299-312 pubmed publisher
Knutson S, Warholic N, Johnston L, Klaus C, Wigle T, Iwanowicz D, et al. Synergistic Anti-Tumor Activity of EZH2 Inhibitors and Glucocorticoid Receptor Agonists in Models of Germinal Center Non-Hodgkin Lymphomas. PLoS ONE. 2014;9:e111840 pubmed publisher
Bullers S, Baker S, Ingham E, Southgate J. The human tissue-biomaterial interface: a role for PPAR?-dependent glucocorticoid receptor activation in regulating the CD163+ M2 macrophage phenotype. Tissue Eng Part A. 2014;20:2390-401 pubmed publisher
Carbone M, Duty S, Rattray M. Riluzole elevates GLT-1 activity and levels in striatal astrocytes. Neurochem Int. 2012;60:31-8 pubmed publisher

product information

brand :

Tocris

master code :

1126

SKU :

1126/100

product name :

Dexamethasone

description :

Anti-inflammatory glucocorticoid

target :

Glucocorticoid Receptor Compounds

category :

Small Molecules

unit size :

100 mg

purity :

98%

observed molecular weight :

392.47

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Glucocorticoid; anti-inflammatory. Reduces levels of activated NF- B in immature dendritic cells (DCs) and inhibits differentiation into mature DCs. Induces differentiation of human mesenchymal stem cells (MSCs). Also used in the generation of liver organoids. Induces autophagy in acute lymphoblastic leukemia (ALL) cell lines. Acts as viral transduction enhancer by promoting intracellular shuttling of HIV-1 pre-integration complex to the nucleus. Additionally Dexamethasone pretreatment in vivo suppresses adaptive immune response to recombinant adenoviral gene transfer vectors. Tocris products are for biomedical research use only. They are not intended for human or veterinary use.

catalog number base :

1126

product keywords :

Anti-inflammatory glucocorticoid receptor Receptors induces differentiation liver organoids viral transduction enhancers Glucocorticoid Receptor Autophagy Mesenchymal Stem Cells NF-kB/IkB Organoids Viral Transduction Enhancers 1126,

extended description :

Anti-inflammatory glucocorticoid

chemical name text :

(11 ,16 )-9-Fluoro-11,17,21-trihydroxy-16-methyl-pregna-1,4-diene-3,20-dione

formula :

C 22 H 29 FO 5

formula text :

C22H29FO5

cas num :

50-02-2

2020 USD :

2021 USD :

88 USD

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage