1126/100 | Tocris Bioscience 1126/100 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

1126/100

catalog :

1126/100

quantity :

100 mg

price :

113 USD

more info or order :

Tocris Bioscience product webpage

citations: 18

Reference
Verstegen M, Roos F, Burka K, Gehart H, Jager M, de Wolf M, et al. Human extrahepatic and intrahepatic cholangiocyte organoids show region-specific differentiation potential and model cystic fibrosis-related bile duct disease. Sci Rep. 2020;10:21900 pubmed publisher
Agasse F, Mendez David I, Christaller W, Carpentier R, Braz B, David D, et al. Chronic Corticosterone Elevation Suppresses Adult Hippocampal Neurogenesis by Hyperphosphorylating Huntingtin. Cell Rep. 2020;32:107865 pubmed publisher
Liu M, Yan Q, Sun Y, Nam Y, Hu L, Loong J, et al. A hepatocyte differentiation model reveals two subtypes of liver cancer with different oncofetal properties and therapeutic targets. Proc Natl Acad Sci U S A. 2020;117:6103-6113 pubmed publisher
Segal J, Kent D, Wesche D, Ng S, Serra M, Oulès B, et al. Single cell analysis of human foetal liver captures the transcriptional profile of hepatobiliary hybrid progenitors. Nat Commun. 2019;10:3350 pubmed publisher
Ibrahim S, Xie W, Strong J, Tonello R, Berta T, Zhang J. Mineralocorticoid Antagonist Improves Glucocorticoid Receptor Signaling and Dexamethasone Analgesia in an Animal Model of Low Back Pain. Front Cell Neurosci. 2018;12:453 pubmed publisher
Peng W, Logan C, Fish M, Anbarchian T, Aguisanda F, Álvarez Varela A, et al. Inflammatory Cytokine TNFα Promotes the Long-Term Expansion of Primary Hepatocytes in 3D Culture. Cell. 2018;175:1607-1619.e15 pubmed publisher
Fagg W, Liu N, Yang M, Cheng K, Chung E, Kim J, et al. Magnetic Targeting of Stem Cell Derivatives Enhances Hepatic Engraftment into Structurally Normal Liver. Cell Transplant. 2017;26:1868-1877 pubmed publisher
Cartledge D, Robbins K, Drake K, Sternberg R, Stabley D, Gripp K, et al. Cytotoxicity of Zardaverine in Embryonal Rhabdomyosarcoma from a Costello Syndrome Patient. Front Oncol. 2017;7:42 pubmed publisher
Sampaziotis F, de Brito M, Geti I, Bertero A, Hannan N, Vallier L. Directed differentiation of human induced pluripotent stem cells into functional cholangiocyte-like cells. Nat Protoc. 2017;12:814-827 pubmed publisher
Pinheiro B, Lemos C, Neutzling Kaufmann F, Marques J, da Silva Santos C, Carvalho E, et al. Hierarchical glucocorticoid-endocannabinoid interplay regulates the activation of the nucleus accumbens by insulin. Brain Res Bull. 2016;124:222-30 pubmed publisher
Sampaziotis F, de Brito M, Madrigal P, Bertero A, Saeb Parsy K, Soares F, et al. Cholangiocytes derived from human induced pluripotent stem cells for disease modeling and drug validation. Nat Biotechnol. 2015;33:845-852 pubmed publisher
Huch M, Gehart H, van Boxtel R, Hamer K, Blokzijl F, Verstegen M, et al. Long-term culture of genome-stable bipotent stem cells from adult human liver. Cell. 2015;160:299-312 pubmed publisher
Knutson S, Warholic N, Johnston L, Klaus C, Wigle T, Iwanowicz D, et al. Synergistic Anti-Tumor Activity of EZH2 Inhibitors and Glucocorticoid Receptor Agonists in Models of Germinal Center Non-Hodgkin Lymphomas. PLoS ONE. 2014;9:e111840 pubmed publisher
Bullers S, Baker S, Ingham E, Southgate J. The human tissue-biomaterial interface: a role for PPAR?-dependent glucocorticoid receptor activation in regulating the CD163+ M2 macrophage phenotype. Tissue Eng Part A. 2014;20:2390-401 pubmed publisher
Kim D, Lee M, Yoo K, Lee T, Kim H, Jang I, et al. Gene expression profiles of human adipose tissue-derived mesenchymal stem cells are modified by cell culture density. PLoS ONE. 2014;9:e83363 pubmed publisher
Burke S, Goff M, Updegraff B, Lu D, Brown P, Minkin S, et al. Regulation of the CCL2 gene in pancreatic ?-cells by IL-1? and glucocorticoids: role of MKP-1. PLoS ONE. 2012;7:e46986 pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Carbone M, Duty S, Rattray M. Riluzole elevates GLT-1 activity and levels in striatal astrocytes. Neurochem Int. 2012;60:31-8 pubmed publisher

product information

master code :

1126

SKU :

1126/100

product name :

Dexamethasone

unit size :

100 mg

description :

Anti-inflammatory glucocorticoid

target :

Glucocorticoid Receptor Compounds

category :

Small Molecules

purity :

98%

observed molecular weight :

392.47

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Dexamethasone is a glucocorticoid; anti-inflammatory. Reduces levels of activated NF- B in immature dendritic cells (DCs) and inhibits differentiation into mature DCs. Induces differentiation of human mesenchymal stem cells (MSCs). Also used in the generation of liver organoids. Induces autophagy in acute lymphoblastic leukemia (ALL) cell lines. Acts as viral transduction enhancer by promoting intracellular shuttling of HIV-1 pre-integration complex to the nucleus. Additionally Dexamethasone pretreatment in vivo suppresses adaptive immune response to recombinant adenoviral gene transfer vectors. Dexamethasone synthesized to Ancillary Material Grade also available. . Tocris products are for biomedical research use only. They are not intended for human or veterinary use.

top caption :

Anti-inflammatory glucocorticoid

extended description :

Anti-inflammatory glucocorticoid

chemical name text :

(11 ,16 )-9-Fluoro-11,17,21-trihydroxy-16-methyl-pregna-1,4-diene-3,20-dione

formula :

C22H29FO5

formula text :

C22H29FO5

cas num :

50-02-2

USD :

113 USD

product details :

Anti-inflammatory glucocorticoid

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage