1116/10 | Tocris Bioscience 1116/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

1116/10

catalog :

1116/10

quantity :

10 mg (also 50 mg)

price :

131 USD

more info or order :

Tocris Bioscience product webpage

citations: 16

Reference
Saliba S, Marcotegui A, Fortwängler E, Ditrich J, Perazzo J, Munoz E, et al. AM404, paracetamol metabolite, prevents prostaglandin synthesis in activated microglia by inhibiting COX activity. J Neuroinflammation. 2017;14:246 pubmed publisher
Murata Y, Sugi T, Weiss L, Kato K. Identification of compounds that suppress Toxoplasma gondii tachyzoites and bradyzoites. PLoS ONE. 2017;12:e0178203 pubmed publisher
Tabatadze N, Huang G, May R, Jain A, Woolley C. Sex Differences in Molecular Signaling at Inhibitory Synapses in the Hippocampus. J Neurosci. 2015;35:11252-65 pubmed publisher
Levin R, Peres F, Almeida V, Calzavara M, Zuardi A, Hallak J, et al. Effects of cannabinoid drugs on the deficit of prepulse inhibition of startle in an animal model of schizophrenia: the SHR strain. Front Pharmacol. 2014;5:10 pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Caiati M, Sivakumaran S, Lanore F, Mulle C, Richard E, Verrier D, et al. Developmental regulation of CB1-mediated spike-time dependent depression at immature mossy fiber-CA3 synapses. Sci Rep. 2012;2:285 pubmed publisher
Buznikov G, Nikitina L, Bezuglov V, Francisco M, Boysen G, Obispo Peak I, et al. A putative 'pre-nervous' endocannabinoid system in early echinoderm development. Dev Neurosci. 2010;32:1-18 pubmed publisher
Brozoski D, Dean C, Hopp F, Hillard C, Seagard J. Differential endocannabinoid regulation of baroreflex-evoked sympathoinhibition in normotensive versus hypertensive rats. Auton Neurosci. 2009;150:82-93 pubmed publisher
Justinova Z, Munzar P, Panlilio L, Yasar S, Redhi G, Tanda G, et al. Blockade of THC-seeking behavior and relapse in monkeys by the cannabinoid CB(1)-receptor antagonist rimonabant. Neuropsychopharmacology. 2008;33:2870-7 pubmed publisher
Herradon E, Martin M, Lopez Miranda V. Characterization of the vasorelaxant mechanisms of the endocannabinoid anandamide in rat aorta. Br J Pharmacol. 2007;152:699-708 pubmed
Lafourcade M, Elezgarai I, Mato S, Bakiri Y, Grandes P, Manzoni O. Molecular components and functions of the endocannabinoid system in mouse prefrontal cortex. PLoS ONE. 2007;2:e709 pubmed
Cenni G, Blandina P, Mackie K, Nosi D, Formigli L, Giannoni P, et al. Differential effect of cannabinoid agonists and endocannabinoids on histamine release from distinct regions of the rat brain. Eur J Neurosci. 2006;24:1633-44 pubmed
Thors L, Fowler C. Is there a temperature-dependent uptake of anandamide into cells?. Br J Pharmacol. 2006;149:73-81 pubmed
Batkai S, Pacher P, Osei Hyiaman D, Radaeva S, Liu J, Harvey White J, et al. Endocannabinoids acting at cannabinoid-1 receptors regulate cardiovascular function in hypertension. Circulation. 2004;110:1996-2002 pubmed
Ronesi J, Gerdeman G, Lovinger D. Disruption of endocannabinoid release and striatal long-term depression by postsynaptic blockade of endocannabinoid membrane transport. J Neurosci. 2004;24:1673-9 pubmed
Craib S, Ellington H, Pertwee R, Ross R. A possible role of lipoxygenase in the activation of vanilloid receptors by anandamide in the guinea-pig bronchus. Br J Pharmacol. 2001;134:30-7 pubmed

product information

master code :

1116

SKU :

1116/10

product name :

AM 404

unit size :

10 mg (also 50 mg)

description :

Anandamide transport inhibitor

target :

Cannabinoid Transporter Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

395.58

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

AM 404 is a competitive and selective inhibitor of carrier-mediated anandamide transport (IC50 = 1 u M). Does not activate CB1 receptors or inhibit anandamide hydrolysis but has been shown to activate native and cloned vanilloid receptors (pEC50 = 7.4). Also FABP inhibitor. Active in vivo .

top caption :

Anandamide transport inhibitor

extended description :

Anandamide transport inhibitor

chemical name text :

N-(4-Hydroxyphenyl)-5Z,8Z,11Z,14Z-eicosatetraenamide

formula :

C26H37NO2

formula text :

C26H37NO2

cas num :

183718-77-6

USD :

131 USD

product details :

Anandamide transport inhibitor

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage