product summary
Loading...
company name :
Tocris Bioscience
product type :
chemical
product name :
1114/10
catalog :
1114/10
quantity :
10 mg (also 50 mg)
price :
276 USD
more info or order :
citations: 14
Reference
Bastioli G, Piccirillo S, Castaldo P, Magi S, Tozzi A, Amoroso S, et al. Selective inhibition of mitochondrial sodium-calcium exchanger protects striatal neurons from α-synuclein plus rotenone induced toxicity. Cell Death Dis. 2019;10:80 pubmed publisher
Panja D, Vedeler C, Schubert M. Paraneoplastic cerebellar degeneration: Yo antibody alters mitochondrial calcium buffering capacity. Neuropathol Appl Neurobiol. 2019;45:141-156 pubmed publisher
Pecze L, Blum W, Schwaller B. Routes of Ca2+ Shuttling during Ca2+ Oscillations: FOCUS ON THE ROLE OF MITOCHONDRIAL Ca2+ HANDLING AND CYTOSOLIC Ca2+ BUFFERS. J Biol Chem. 2015;290:28214-30 pubmed publisher
Yang R, Lirussi D, Thornton T, Jelley Gibbs D, DIEHL S, Case L, et al. Mitochondrial Ca²⁺ and membrane potential, an alternative pathway for Interleukin 6 to regulate CD4 cell effector function. elife. 2015;4: pubmed publisher
Lin T, Lu C, Wu C, Huang S, Wang S. Palmitoylethanolamide inhibits glutamate release in rat cerebrocortical nerve terminals. Int J Mol Sci. 2015;16:5555-71 pubmed publisher
Blomeyer C, Bazil J, Stowe D, Pradhan R, Dash R, Camara A. Dynamic buffering of mitochondrial Ca2+ during Ca2+ uptake and Na+-induced Ca2+ release. J Bioenerg Biomembr. 2013;45:189-202 pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Pandit M, Strait K, Matsuda T, Kohan D. Na delivery and ENaC mediate flow regulation of collecting duct endothelin-1 production. Am J Physiol Renal Physiol. 2012;302:F1325-30 pubmed publisher
Midkiff J, Borochoff Porte N, White D, Johnson D. Small molecule inhibitors of the Candida albicans budded-to-hyphal transition act through multiple signaling pathways. PLoS ONE. 2011;6:e25395 pubmed publisher
Zhdanov A, Dmitriev R, Papkovsky D. Bafilomycin A1 activates respiration of neuronal cells via uncoupling associated with flickering depolarization of mitochondria. Cell Mol Life Sci. 2011;68:903-17 pubmed publisher
Lee D, Lee K, Ho W, Lee S. Target cell-specific involvement of presynaptic mitochondria in post-tetanic potentiation at hippocampal mossy fiber synapses. J Neurosci. 2007;27:13603-13 pubmed
Kim B, Jun J, So I, Kim K. Involvement of mitochondrial Na+-Ca2+ exchange in intestinal pacemaking activity. World J Gastroenterol. 2006;12:796-9 pubmed
Nikolaeva M, Mukherjee B, Stys P. Na+-dependent sources of intra-axonal Ca2+ release in rat optic nerve during in vitro chemical ischemia. J Neurosci. 2005;25:9960-7 pubmed
Schild L, Huppelsberg J, Kahlert S, Keilhoff G, Reiser G. Brain mitochondria are primed by moderate Ca2+ rise upon hypoxia/reoxygenation for functional breakdown and morphological disintegration. J Biol Chem. 2003;278:25454-60 pubmed
product information
master code :
1114
SKU :
1114/10
product name :
CGP 37157
unit size :
10 mg (also 50 mg)
description :
Antagonist of mitochondrial Na+/Ca2+ exchange
target :
Na+/Ca2+ Exchanger Inhibitors
category :
Small Molecules
purity :
99%
observed molecular weight :
324.22
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
CGP 37157 is a selective antagonist of the mitochondrial Na+/Ca2+ exchanger (NCX; IC50 = 0.4 u M).
top caption :
Antagonist of mitochondrial Na+/Ca2+ exchange
extended description :
Antagonist of mitochondrial Na+/Ca2+ exchange
chemical name text :
7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one
formula :
C15H11Cl2NOS
formula text :
C15H11Cl2NOS
cas num :
75450-34-9
USD :
276 USD
product details :
Antagonist of mitochondrial Na+/Ca2+ exchange
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK