1110/10 | Tocris Bioscience 1110/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

1110/10

catalog :

1110/10

quantity :

10 mg (also 50 mg)

price :

81 USD

more info or order :

Tocris Bioscience product webpage

citations: 11

Reference
Kim J, Leem Y, Kwon I, Kang J, Bae Y, Cho H. Estrogen modulates serotonin effects on vasoconstriction through Src inhibition. Exp Mol Med. 2018;50:167 pubmed publisher
Olianas M, Dedoni S, Onali P. The GABAB positive allosteric modulators CGP7930 and GS39783 stimulate ERK1/2 signalling in cells lacking functional GABAB receptors. Eur J Pharmacol. 2017;794:135-146 pubmed publisher
Liu Z, Chen J, Mirando A, Wang C, Zuscik M, O Keefe R, et al. A dual role for NOTCH signaling in joint cartilage maintenance and osteoarthritis. Sci Signal. 2015;8:ra71 pubmed publisher
Accardi M, Brown P, Miraucourt L, Orser B, Bowie D. Î±6-Containing GABAA Receptors Are the Principal Mediators of Inhibitory Synapse Strengthening by Insulin in Cerebellar Granule Cells. J Neurosci. 2015;35:9676-88 pubmed publisher
Mansouri Attia N, James R, Ligon A, Li X, Pangas S. Soy promotes juvenile granulosa cell tumor development in mice and in the human granulosa cell tumor-derived COV434 cell line. Biol Reprod. 2014;91:100 pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Bigford G, Chaudhry N, Keane R, Holohean A. 5-Hydroxytryptamine 5HT2C receptors form a protein complex with N-methyl-D-aspartate GluN2A subunits and activate phosphorylation of Src protein to modulate motoneuronal depolarization. J Biol Chem. 2012;287:11049-59 pubmed publisher
Li C, Dabrowska J, Hazra R, Rainnie D. Synergistic activation of dopamine D1 and TrkB receptors mediate gain control of synaptic plasticity in the basolateral amygdala. PLoS ONE. 2011;6:e26065 pubmed publisher
Melis M, Pillolla G, Luchicchi A, Muntoni A, Yasar S, Goldberg S, et al. Endogenous fatty acid ethanolamides suppress nicotine-induced activation of mesolimbic dopamine neurons through nuclear receptors. J Neurosci. 2008;28:13985-94 pubmed publisher
Rojas A, Cui N, Su J, Yang L, Muhumuza J, Jiang C. Protein kinase C dependent inhibition of the heteromeric Kir4.1-Kir5.1 channel. Biochim Biophys Acta. 2007;1768:2030-42 pubmed
Alao J, Stavropoulou A, Lam E, Coombes R. Role of glycogen synthase kinase 3 beta (GSK3beta) in mediating the cytotoxic effects of the histone deacetylase inhibitor trichostatin A (TSA) in MCF-7 breast cancer cells. Mol Cancer. 2006;5:40 pubmed

product information

master code :

1110

SKU :

1110/10

product name :

Genistein

unit size :

10 mg (also 50 mg)

description :

EGFR kinase inhibitor. Also estrogen and PPAR ligand

target :

EGF Receptor Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

270.24

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Genistein is a phytoestrogen with a wide range of biological actions. Genistein inhibits protein tyrosine kinases including epidermal growth factor receptor kinase, binds to PPAR and estrogen receptors and acts as an agonist at GPER. Genistein inhibits aggregation and fibrilization of A 42 and amylin37 (hiAPP). In Huntington s disease fibroblast cells, Genistein reduces intracellular mutant huntingtin (mHTT) aggregates and induces degradation of mHTT; in a cellular model of Huntington s disease, Genistein corrects the mutant phenotype through stimulation of autophagy.

top caption :

EGFR kinase inhibitor. Also estrogen and PPAR ligand

extended description :

EGFR kinase inhibitor. Also estrogen and PPAR ligand

chemical name text :

5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one

formula :

C15H10O5

formula text :

C15H10O5

cas num :

446-72-0

USD :

81 USD

product details :

EGFR kinase inhibitor. Also estrogen and PPAR ligand

storage :

Desiccate at -20░C

more info or order :

Tocris Bioscience product webpage